Single-cell Rapid Capture Hybridization sequencing reliably detects isoform usage and coding mutations in targeted genes Article Swipe
Hongke Peng
,
Jafar S. Jabbari
,
Luyi Tian
,
Changqing Wang
,
Yupei You
,
Chong Chyn Chua
,
Natasha S. Anstee
,
Noorul Amin
,
Andrew H. Wei
,
N. Davidson
,
Andrew W. Roberts
,
David C.S. Huang
,
Matthew E. Ritchie
,
Rachel Thijssen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/gr.279322.124
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/gr.279322.124
Single-cell long-read sequencing has transformed our understanding of isoform usage and the mutation heterogeneity between cells. Despite unbiased in-depth analysis, the low sequencing throughput often results in insufficient read coverage, thereby limiting our ability to perform mutation calling for specific genes. Here, we developed a single-cell Rapid Capture Hybridization sequencing (scRaCH-seq) method that demonstrates high specificity and efficiency in capturing targeted transcripts using long-read sequencing, allowing an in-depth analysis of mutation status and transcript usage for genes of interest. The method includes creating a probe panel for transcript capture, using barcoded primers for pooling and efficient sequencing via Oxford Nanopore Technologies platforms. scRaCH-seq is applicable to stored and indexed single-cell cDNA, which allows analysis to be combined with existing short-read RNA-seq data sets. In our investigation of BTK and SF3B1 genes in samples from patients with chronic lymphocytic leukemia (CLL), we detect SF3B1 isoforms and mutations with high sensitivity. Integration with short-read single-cell RNA sequencing (scRNA-seq) data reveals significant gene expression differences in SF3B1 -mutated CLL cells, although it does not impact the sensitivity of the anticancer drug venetoclax. scRaCH-seq's capability to study long-read transcripts of multiple genes makes it a powerful tool for single-cell genomics.
Related Topics
Concepts
Biology
Single cell sequencing
Gene
Genetics
Computational biology
DNA sequencing
Deep sequencing
Cancer genome sequencing
Genomics
Massive parallel sequencing
Complementary DNA
Single-cell analysis
Mutation
Genome
Exome sequencing
Cell
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/gr.279322.124
- https://genome.cshlp.org/content/early/2025/01/10/gr.279322.124.full.pdf
- OA Status
- hybrid
- Cited By
- 5
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406263596
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4406263596Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/gr.279322.124Digital Object Identifier
- Title
-
Single-cell Rapid Capture Hybridization sequencing reliably detects isoform usage and coding mutations in targeted genesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-10Full publication date if available
- Authors
-
Hongke Peng, Jafar S. Jabbari, Luyi Tian, Changqing Wang, Yupei You, Chong Chyn Chua, Natasha S. Anstee, Noorul Amin, Andrew H. Wei, N. Davidson, Andrew W. Roberts, David C.S. Huang, Matthew E. Ritchie, Rachel ThijssenList of authors in order
- Landing page
-
https://doi.org/10.1101/gr.279322.124Publisher landing page
- PDF URL
-
https://genome.cshlp.org/content/early/2025/01/10/gr.279322.124.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://genome.cshlp.org/content/early/2025/01/10/gr.279322.124.full.pdfDirect OA link when available
- Concepts
-
Biology, Single cell sequencing, Gene, Genetics, Computational biology, DNA sequencing, Deep sequencing, Cancer genome sequencing, Genomics, Massive parallel sequencing, Complementary DNA, Single-cell analysis, Mutation, Genome, Exome sequencing, CellTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5Per-year citation counts (last 5 years)
- References (count)
-
41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4406263596 |
|---|---|
| doi | https://doi.org/10.1101/gr.279322.124 |
| ids.doi | https://doi.org/10.1101/gr.279322.124 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39794120 |
| ids.openalex | https://openalex.org/W4406263596 |
| fwci | 13.41472314 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000379 |
| mesh[1].descriptor_ui | D059010 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | methods |
| mesh[1].descriptor_name | Single-Cell Analysis |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D009154 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Mutation |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D015451 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | Leukemia, Lymphocytic, Chronic, B-Cell |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D020033 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Protein Isoforms |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D000077329 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Agammaglobulinaemia Tyrosine Kinase |
| mesh[6].qualifier_ui | Q000379 |
| mesh[6].descriptor_ui | D059014 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | methods |
| mesh[6].descriptor_name | High-Throughput Nucleotide Sequencing |
| mesh[7].qualifier_ui | Q000379 |
| mesh[7].descriptor_ui | D009693 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | methods |
| mesh[7].descriptor_name | Nucleic Acid Hybridization |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000072260 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | RNA Splicing Factors |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D010750 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Phosphoproteins |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D006801 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Humans |
| mesh[11].qualifier_ui | Q000379 |
| mesh[11].descriptor_ui | D059010 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | methods |
| mesh[11].descriptor_name | Single-Cell Analysis |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D009154 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mutation |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D015451 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Leukemia, Lymphocytic, Chronic, B-Cell |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D020033 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Protein Isoforms |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D000077329 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Agammaglobulinaemia Tyrosine Kinase |
| mesh[16].qualifier_ui | Q000379 |
| mesh[16].descriptor_ui | D059014 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | methods |
| mesh[16].descriptor_name | High-Throughput Nucleotide Sequencing |
| mesh[17].qualifier_ui | Q000379 |
| mesh[17].descriptor_ui | D009693 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | methods |
| mesh[17].descriptor_name | Nucleic Acid Hybridization |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000072260 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | RNA Splicing Factors |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D010750 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Phosphoproteins |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D006801 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Humans |
| mesh[21].qualifier_ui | Q000379 |
| mesh[21].descriptor_ui | D059010 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | methods |
| mesh[21].descriptor_name | Single-Cell Analysis |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D009154 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Mutation |
| mesh[23].qualifier_ui | Q000235 |
| mesh[23].descriptor_ui | D015451 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | genetics |
| mesh[23].descriptor_name | Leukemia, Lymphocytic, Chronic, B-Cell |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D020033 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Protein Isoforms |
| mesh[25].qualifier_ui | Q000235 |
| mesh[25].descriptor_ui | D000077329 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | genetics |
| mesh[25].descriptor_name | Agammaglobulinaemia Tyrosine Kinase |
| mesh[26].qualifier_ui | Q000379 |
| mesh[26].descriptor_ui | D059014 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | methods |
| mesh[26].descriptor_name | High-Throughput Nucleotide Sequencing |
| mesh[27].qualifier_ui | Q000379 |
| mesh[27].descriptor_ui | D009693 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | methods |
| mesh[27].descriptor_name | Nucleic Acid Hybridization |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D000072260 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | RNA Splicing Factors |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D010750 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Phosphoproteins |
| type | article |
| title | Single-cell Rapid Capture Hybridization sequencing reliably detects isoform usage and coding mutations in targeted genes |
| biblio.issue | 4 |
| biblio.volume | 35 |
| biblio.last_page | 955 |
| biblio.first_page | 942 |
| topics[0].id | https://openalex.org/T11289 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Single-cell and spatial transcriptomics |
| topics[1].id | https://openalex.org/T11157 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9954000115394592 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2716 |
| topics[1].subfield.display_name | Genetics |
| topics[1].display_name | Chronic Lymphocytic Leukemia Research |
| topics[2].id | https://openalex.org/T11287 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9932000041007996 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1306 |
| topics[2].subfield.display_name | Cancer Research |
| topics[2].display_name | Cancer Genomics and Diagnostics |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8052957057952881 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C174749747 |
| concepts[1].level | 5 |
| concepts[1].score | 0.6636719107627869 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q15917269 |
| concepts[1].display_name | Single cell sequencing |
| concepts[2].id | https://openalex.org/C104317684 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5862487554550171 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[2].display_name | Gene |
| concepts[3].id | https://openalex.org/C54355233 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5530991554260254 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[3].display_name | Genetics |
| concepts[4].id | https://openalex.org/C70721500 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5385180115699768 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[4].display_name | Computational biology |
| concepts[5].id | https://openalex.org/C51679486 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4583432674407959 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q380546 |
| concepts[5].display_name | DNA sequencing |
| concepts[6].id | https://openalex.org/C132917006 |
| concepts[6].level | 4 |
| concepts[6].score | 0.45137161016464233 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q5250436 |
| concepts[6].display_name | Deep sequencing |
| concepts[7].id | https://openalex.org/C205270622 |
| concepts[7].level | 5 |
| concepts[7].score | 0.4370710849761963 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q17082639 |
| concepts[7].display_name | Cancer genome sequencing |
| concepts[8].id | https://openalex.org/C189206191 |
| concepts[8].level | 4 |
| concepts[8].score | 0.4231400191783905 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q222046 |
| concepts[8].display_name | Genomics |
| concepts[9].id | https://openalex.org/C192800701 |
| concepts[9].level | 4 |
| concepts[9].score | 0.42224404215812683 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q6784807 |
| concepts[9].display_name | Massive parallel sequencing |
| concepts[10].id | https://openalex.org/C187882448 |
| concepts[10].level | 3 |
| concepts[10].score | 0.42182743549346924 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q283478 |
| concepts[10].display_name | Complementary DNA |
| concepts[11].id | https://openalex.org/C2776950831 |
| concepts[11].level | 3 |
| concepts[11].score | 0.4209628999233246 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q15635432 |
| concepts[11].display_name | Single-cell analysis |
| concepts[12].id | https://openalex.org/C501734568 |
| concepts[12].level | 3 |
| concepts[12].score | 0.4204961657524109 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q42918 |
| concepts[12].display_name | Mutation |
| concepts[13].id | https://openalex.org/C141231307 |
| concepts[13].level | 3 |
| concepts[13].score | 0.35823577642440796 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7020 |
| concepts[13].display_name | Genome |
| concepts[14].id | https://openalex.org/C16671776 |
| concepts[14].level | 4 |
| concepts[14].score | 0.31859177350997925 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q5420592 |
| concepts[14].display_name | Exome sequencing |
| concepts[15].id | https://openalex.org/C1491633281 |
| concepts[15].level | 2 |
| concepts[15].score | 0.18529313802719116 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[15].display_name | Cell |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.8052957057952881 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/single-cell-sequencing |
| keywords[1].score | 0.6636719107627869 |
| keywords[1].display_name | Single cell sequencing |
| keywords[2].id | https://openalex.org/keywords/gene |
| keywords[2].score | 0.5862487554550171 |
| keywords[2].display_name | Gene |
| keywords[3].id | https://openalex.org/keywords/genetics |
| keywords[3].score | 0.5530991554260254 |
| keywords[3].display_name | Genetics |
| keywords[4].id | https://openalex.org/keywords/computational-biology |
| keywords[4].score | 0.5385180115699768 |
| keywords[4].display_name | Computational biology |
| keywords[5].id | https://openalex.org/keywords/dna-sequencing |
| keywords[5].score | 0.4583432674407959 |
| keywords[5].display_name | DNA sequencing |
| keywords[6].id | https://openalex.org/keywords/deep-sequencing |
| keywords[6].score | 0.45137161016464233 |
| keywords[6].display_name | Deep sequencing |
| keywords[7].id | https://openalex.org/keywords/cancer-genome-sequencing |
| keywords[7].score | 0.4370710849761963 |
| keywords[7].display_name | Cancer genome sequencing |
| keywords[8].id | https://openalex.org/keywords/genomics |
| keywords[8].score | 0.4231400191783905 |
| keywords[8].display_name | Genomics |
| keywords[9].id | https://openalex.org/keywords/massive-parallel-sequencing |
| keywords[9].score | 0.42224404215812683 |
| keywords[9].display_name | Massive parallel sequencing |
| keywords[10].id | https://openalex.org/keywords/complementary-dna |
| keywords[10].score | 0.42182743549346924 |
| keywords[10].display_name | Complementary DNA |
| keywords[11].id | https://openalex.org/keywords/single-cell-analysis |
| keywords[11].score | 0.4209628999233246 |
| keywords[11].display_name | Single-cell analysis |
| keywords[12].id | https://openalex.org/keywords/mutation |
| keywords[12].score | 0.4204961657524109 |
| keywords[12].display_name | Mutation |
| keywords[13].id | https://openalex.org/keywords/genome |
| keywords[13].score | 0.35823577642440796 |
| keywords[13].display_name | Genome |
| keywords[14].id | https://openalex.org/keywords/exome-sequencing |
| keywords[14].score | 0.31859177350997925 |
| keywords[14].display_name | Exome sequencing |
| keywords[15].id | https://openalex.org/keywords/cell |
| keywords[15].score | 0.18529313802719116 |
| keywords[15].display_name | Cell |
| language | en |
| locations[0].id | doi:10.1101/gr.279322.124 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S43092948 |
| locations[0].source.issn | 1088-9051, 1549-5469 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1088-9051 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Genome Research |
| locations[0].source.host_organization | https://openalex.org/P4310315909 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315909 |
| locations[0].source.host_organization_lineage_names | Cold Spring Harbor Laboratory Press |
| locations[0].license | |
| locations[0].pdf_url | https://genome.cshlp.org/content/early/2025/01/10/gr.279322.124.full.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Genome Research |
| locations[0].landing_page_url | https://doi.org/10.1101/gr.279322.124 |
| locations[1].id | pmid:39794120 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Genome research |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39794120 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:12047256 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Genome Res |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12047256 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5043097788 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4813-0827 |
| authorships[0].author.display_name | Hongke Peng |
| authorships[0].countries | AU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[0].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[0].institutions[0].id | https://openalex.org/I165779595 |
| authorships[0].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[0].institutions[0].country_code | AU |
| authorships[0].institutions[0].display_name | The University of Melbourne |
| authorships[0].institutions[1].id | https://openalex.org/I196021976 |
| authorships[0].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[0].institutions[1].type | nonprofit |
| authorships[0].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[0].institutions[1].country_code | AU |
| authorships[0].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hongke Peng |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[1].author.id | https://openalex.org/A5072422661 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6302-4857 |
| authorships[1].author.display_name | Jafar S. Jabbari |
| authorships[1].countries | AU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[1].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[1].institutions[0].id | https://openalex.org/I165779595 |
| authorships[1].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[1].institutions[0].country_code | AU |
| authorships[1].institutions[0].display_name | The University of Melbourne |
| authorships[1].institutions[1].id | https://openalex.org/I196021976 |
| authorships[1].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[1].institutions[1].type | nonprofit |
| authorships[1].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[1].institutions[1].country_code | AU |
| authorships[1].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Jafar S. Jabbari |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[2].author.id | https://openalex.org/A5075619170 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3420-3685 |
| authorships[2].author.display_name | Luyi Tian |
| authorships[2].countries | AU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[2].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[2].institutions[0].id | https://openalex.org/I165779595 |
| authorships[2].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[2].institutions[0].country_code | AU |
| authorships[2].institutions[0].display_name | The University of Melbourne |
| authorships[2].institutions[1].id | https://openalex.org/I196021976 |
| authorships[2].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[2].institutions[1].type | nonprofit |
| authorships[2].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[2].institutions[1].country_code | AU |
| authorships[2].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Luyi Tian |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[3].author.id | https://openalex.org/A5083179819 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7868-3882 |
| authorships[3].author.display_name | Changqing Wang |
| authorships[3].countries | AU |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[3].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[3].institutions[0].id | https://openalex.org/I165779595 |
| authorships[3].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[3].institutions[0].country_code | AU |
| authorships[3].institutions[0].display_name | The University of Melbourne |
| authorships[3].institutions[1].id | https://openalex.org/I196021976 |
| authorships[3].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[3].institutions[1].type | nonprofit |
| authorships[3].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[3].institutions[1].country_code | AU |
| authorships[3].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Changqing Wang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[4].author.id | https://openalex.org/A5080393309 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-7302-3033 |
| authorships[4].author.display_name | Yupei You |
| authorships[4].countries | AU |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[4].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[4].institutions[0].id | https://openalex.org/I165779595 |
| authorships[4].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[4].institutions[0].country_code | AU |
| authorships[4].institutions[0].display_name | The University of Melbourne |
| authorships[4].institutions[1].id | https://openalex.org/I196021976 |
| authorships[4].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[4].institutions[1].type | nonprofit |
| authorships[4].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[4].institutions[1].country_code | AU |
| authorships[4].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yupei You |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[5].author.id | https://openalex.org/A5041083418 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2162-3288 |
| authorships[5].author.display_name | Chong Chyn Chua |
| authorships[5].countries | AU |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I189966903, https://openalex.org/I196021976, https://openalex.org/I4210121067 |
| authorships[5].affiliations[0].raw_affiliation_string | 2 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Monash Health, Northern Health |
| authorships[5].institutions[0].id | https://openalex.org/I4210121067 |
| authorships[5].institutions[0].ror | https://ror.org/02t1bej08 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210121067 |
| authorships[5].institutions[0].country_code | AU |
| authorships[5].institutions[0].display_name | Monash Health |
| authorships[5].institutions[1].id | https://openalex.org/I189966903 |
| authorships[5].institutions[1].ror | https://ror.org/009k7c907 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I189966903 |
| authorships[5].institutions[1].country_code | AU |
| authorships[5].institutions[1].display_name | Northern Health |
| authorships[5].institutions[2].id | https://openalex.org/I196021976 |
| authorships[5].institutions[2].ror | https://ror.org/01b6kha49 |
| authorships[5].institutions[2].type | nonprofit |
| authorships[5].institutions[2].lineage | https://openalex.org/I196021976 |
| authorships[5].institutions[2].country_code | AU |
| authorships[5].institutions[2].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Chong Chyn Chua |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | 2 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Monash Health, Northern Health |
| authorships[6].author.id | https://openalex.org/A5060566535 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-2093-1403 |
| authorships[6].author.display_name | Natasha S. Anstee |
| authorships[6].countries | AU |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[6].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[6].institutions[0].id | https://openalex.org/I165779595 |
| authorships[6].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[6].institutions[0].country_code | AU |
| authorships[6].institutions[0].display_name | The University of Melbourne |
| authorships[6].institutions[1].id | https://openalex.org/I196021976 |
| authorships[6].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[6].institutions[1].type | nonprofit |
| authorships[6].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[6].institutions[1].country_code | AU |
| authorships[6].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Natasha S. Anstee |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[7].author.id | https://openalex.org/A5012233367 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-7747-7956 |
| authorships[7].author.display_name | Noorul Amin |
| authorships[7].countries | AU |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[7].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[7].institutions[0].id | https://openalex.org/I165779595 |
| authorships[7].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[7].institutions[0].country_code | AU |
| authorships[7].institutions[0].display_name | The University of Melbourne |
| authorships[7].institutions[1].id | https://openalex.org/I196021976 |
| authorships[7].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[7].institutions[1].type | nonprofit |
| authorships[7].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[7].institutions[1].country_code | AU |
| authorships[7].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Noorul Amin |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[8].author.id | https://openalex.org/A5005591514 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-7514-3298 |
| authorships[8].author.display_name | Andrew H. Wei |
| authorships[8].countries | AU |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1320473756, https://openalex.org/I165779595, https://openalex.org/I196021976, https://openalex.org/I2800555584 |
| authorships[8].affiliations[0].raw_affiliation_string | 3 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Royal Melbourne Hospital and Peter MacCallum Cancer Centre |
| authorships[8].institutions[0].id | https://openalex.org/I2800555584 |
| authorships[8].institutions[0].ror | https://ror.org/02a8bt934 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I2800555584 |
| authorships[8].institutions[0].country_code | AU |
| authorships[8].institutions[0].display_name | Peter MacCallum Cancer Centre |
| authorships[8].institutions[1].id | https://openalex.org/I1320473756 |
| authorships[8].institutions[1].ror | https://ror.org/005bvs909 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I1320473756, https://openalex.org/I4210158168 |
| authorships[8].institutions[1].country_code | AU |
| authorships[8].institutions[1].display_name | The Royal Melbourne Hospital |
| authorships[8].institutions[2].id | https://openalex.org/I165779595 |
| authorships[8].institutions[2].ror | https://ror.org/01ej9dk98 |
| authorships[8].institutions[2].type | education |
| authorships[8].institutions[2].lineage | https://openalex.org/I165779595 |
| authorships[8].institutions[2].country_code | AU |
| authorships[8].institutions[2].display_name | The University of Melbourne |
| authorships[8].institutions[3].id | https://openalex.org/I196021976 |
| authorships[8].institutions[3].ror | https://ror.org/01b6kha49 |
| authorships[8].institutions[3].type | nonprofit |
| authorships[8].institutions[3].lineage | https://openalex.org/I196021976 |
| authorships[8].institutions[3].country_code | AU |
| authorships[8].institutions[3].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Andrew H. Wei |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | 3 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Royal Melbourne Hospital and Peter MacCallum Cancer Centre |
| authorships[9].author.id | https://openalex.org/A5009364443 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-8461-7467 |
| authorships[9].author.display_name | N. Davidson |
| authorships[9].countries | AU |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[9].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[9].institutions[0].id | https://openalex.org/I165779595 |
| authorships[9].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[9].institutions[0].country_code | AU |
| authorships[9].institutions[0].display_name | The University of Melbourne |
| authorships[9].institutions[1].id | https://openalex.org/I196021976 |
| authorships[9].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[9].institutions[1].type | nonprofit |
| authorships[9].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[9].institutions[1].country_code | AU |
| authorships[9].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Nadia Davidson |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[10].author.id | https://openalex.org/A5033407869 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-7341-5720 |
| authorships[10].author.display_name | Andrew W. Roberts |
| authorships[10].countries | AU |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1320473756, https://openalex.org/I165779595, https://openalex.org/I196021976, https://openalex.org/I2800555584 |
| authorships[10].affiliations[0].raw_affiliation_string | 3 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Royal Melbourne Hospital and Peter MacCallum Cancer Centre |
| authorships[10].institutions[0].id | https://openalex.org/I2800555584 |
| authorships[10].institutions[0].ror | https://ror.org/02a8bt934 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I2800555584 |
| authorships[10].institutions[0].country_code | AU |
| authorships[10].institutions[0].display_name | Peter MacCallum Cancer Centre |
| authorships[10].institutions[1].id | https://openalex.org/I1320473756 |
| authorships[10].institutions[1].ror | https://ror.org/005bvs909 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I1320473756, https://openalex.org/I4210158168 |
| authorships[10].institutions[1].country_code | AU |
| authorships[10].institutions[1].display_name | The Royal Melbourne Hospital |
| authorships[10].institutions[2].id | https://openalex.org/I165779595 |
| authorships[10].institutions[2].ror | https://ror.org/01ej9dk98 |
| authorships[10].institutions[2].type | education |
| authorships[10].institutions[2].lineage | https://openalex.org/I165779595 |
| authorships[10].institutions[2].country_code | AU |
| authorships[10].institutions[2].display_name | The University of Melbourne |
| authorships[10].institutions[3].id | https://openalex.org/I196021976 |
| authorships[10].institutions[3].ror | https://ror.org/01b6kha49 |
| authorships[10].institutions[3].type | nonprofit |
| authorships[10].institutions[3].lineage | https://openalex.org/I196021976 |
| authorships[10].institutions[3].country_code | AU |
| authorships[10].institutions[3].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Andrew W. Roberts |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | 3 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Royal Melbourne Hospital and Peter MacCallum Cancer Centre |
| authorships[11].author.id | https://openalex.org/A5040208750 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-3101-4873 |
| authorships[11].author.display_name | David C.S. Huang |
| authorships[11].countries | AU |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[11].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[11].institutions[0].id | https://openalex.org/I165779595 |
| authorships[11].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[11].institutions[0].country_code | AU |
| authorships[11].institutions[0].display_name | The University of Melbourne |
| authorships[11].institutions[1].id | https://openalex.org/I196021976 |
| authorships[11].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[11].institutions[1].type | nonprofit |
| authorships[11].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[11].institutions[1].country_code | AU |
| authorships[11].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | David Huang |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[12].author.id | https://openalex.org/A5015434839 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-7383-0609 |
| authorships[12].author.display_name | Matthew E. Ritchie |
| authorships[12].countries | AU |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I196021976 |
| authorships[12].affiliations[0].raw_affiliation_string | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[12].institutions[0].id | https://openalex.org/I165779595 |
| authorships[12].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[12].institutions[0].country_code | AU |
| authorships[12].institutions[0].display_name | The University of Melbourne |
| authorships[12].institutions[1].id | https://openalex.org/I196021976 |
| authorships[12].institutions[1].ror | https://ror.org/01b6kha49 |
| authorships[12].institutions[1].type | nonprofit |
| authorships[12].institutions[1].lineage | https://openalex.org/I196021976 |
| authorships[12].institutions[1].country_code | AU |
| authorships[12].institutions[1].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Matthew E Ritchie |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | 1 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne |
| authorships[13].author.id | https://openalex.org/A5090951268 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-4493-306X |
| authorships[13].author.display_name | Rachel Thijssen |
| authorships[13].countries | AU, NL |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I196021976, https://openalex.org/I4210151833 |
| authorships[13].affiliations[0].raw_affiliation_string | 4 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Amsterdam UMC, Cancer Center Amsterdam |
| authorships[13].institutions[0].id | https://openalex.org/I196021976 |
| authorships[13].institutions[0].ror | https://ror.org/01b6kha49 |
| authorships[13].institutions[0].type | nonprofit |
| authorships[13].institutions[0].lineage | https://openalex.org/I196021976 |
| authorships[13].institutions[0].country_code | AU |
| authorships[13].institutions[0].display_name | Walter and Eliza Hall Institute of Medical Research |
| authorships[13].institutions[1].id | https://openalex.org/I4210151833 |
| authorships[13].institutions[1].ror | https://ror.org/05grdyy37 |
| authorships[13].institutions[1].type | healthcare |
| authorships[13].institutions[1].lineage | https://openalex.org/I4210151833 |
| authorships[13].institutions[1].country_code | NL |
| authorships[13].institutions[1].display_name | Amsterdam University Medical Centers |
| authorships[13].author_position | last |
| authorships[13].raw_author_name | Rachel Thijssen |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | 4 The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Amsterdam UMC, Cancer Center Amsterdam |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://genome.cshlp.org/content/early/2025/01/10/gr.279322.124.full.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-01-11T00:00:00 |
| display_name | Single-cell Rapid Capture Hybridization sequencing reliably detects isoform usage and coding mutations in targeted genes |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T11289 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Single-cell and spatial transcriptomics |
| related_works | https://openalex.org/W4220852060, https://openalex.org/W2734237109, https://openalex.org/W2981524198, https://openalex.org/W2522810657, https://openalex.org/W1978155433, https://openalex.org/W2095901358, https://openalex.org/W2359210733, https://openalex.org/W4213107689, https://openalex.org/W1980784781, https://openalex.org/W103372765 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1101/gr.279322.124 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S43092948 |
| best_oa_location.source.issn | 1088-9051, 1549-5469 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1088-9051 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Genome Research |
| best_oa_location.source.host_organization | https://openalex.org/P4310315909 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315909 |
| best_oa_location.source.host_organization_lineage_names | Cold Spring Harbor Laboratory Press |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://genome.cshlp.org/content/early/2025/01/10/gr.279322.124.full.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Genome Research |
| best_oa_location.landing_page_url | https://doi.org/10.1101/gr.279322.124 |
| primary_location.id | doi:10.1101/gr.279322.124 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S43092948 |
| primary_location.source.issn | 1088-9051, 1549-5469 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1088-9051 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Genome Research |
| primary_location.source.host_organization | https://openalex.org/P4310315909 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315909 |
| primary_location.source.host_organization_lineage_names | Cold Spring Harbor Laboratory Press |
| primary_location.license | |
| primary_location.pdf_url | https://genome.cshlp.org/content/early/2025/01/10/gr.279322.124.full.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Genome Research |
| primary_location.landing_page_url | https://doi.org/10.1101/gr.279322.124 |
| publication_date | 2025-01-10 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4394759187, https://openalex.org/W4385795963, https://openalex.org/W4379645224, https://openalex.org/W4380577748, https://openalex.org/W2984472267, https://openalex.org/W2136272158, https://openalex.org/W2773946416, https://openalex.org/W3048389895, https://openalex.org/W2789843538, https://openalex.org/W2214074259, https://openalex.org/W4309078073, https://openalex.org/W2951158909, https://openalex.org/W4210751097, https://openalex.org/W4295509389, https://openalex.org/W2954384525, https://openalex.org/W2114104545, https://openalex.org/W2068887701, https://openalex.org/W2076687510, https://openalex.org/W4283809266, https://openalex.org/W3006044557, https://openalex.org/W2739492614, https://openalex.org/W2949177718, https://openalex.org/W2149573463, https://openalex.org/W3011428862, https://openalex.org/W4282976889, https://openalex.org/W3217383240, https://openalex.org/W3214478476, https://openalex.org/W4301370233, https://openalex.org/W2092582534, https://openalex.org/W3087483307, https://openalex.org/W4308736832, https://openalex.org/W4312193589, https://openalex.org/W4327919084, https://openalex.org/W3175752499, https://openalex.org/W4289516943, https://openalex.org/W2971269466, https://openalex.org/W4281619903, https://openalex.org/W2986870529, https://openalex.org/W4386050348, https://openalex.org/W2582743722, https://openalex.org/W3048152825 |
| referenced_works_count | 41 |
| abstract_inverted_index.a | 44, 83, 190 |
| abstract_inverted_index.In | 123 |
| abstract_inverted_index.an | 66 |
| abstract_inverted_index.be | 115 |
| abstract_inverted_index.in | 26, 58, 131, 162 |
| abstract_inverted_index.is | 103 |
| abstract_inverted_index.it | 168, 189 |
| abstract_inverted_index.of | 7, 69, 77, 126, 174, 185 |
| abstract_inverted_index.to | 34, 105, 114, 181 |
| abstract_inverted_index.we | 42, 140 |
| abstract_inverted_index.BTK | 127 |
| abstract_inverted_index.CLL | 165 |
| abstract_inverted_index.RNA | 153 |
| abstract_inverted_index.The | 79 |
| abstract_inverted_index.and | 10, 56, 72, 94, 107, 128, 144 |
| abstract_inverted_index.for | 38, 75, 86, 92, 193 |
| abstract_inverted_index.has | 3 |
| abstract_inverted_index.low | 21 |
| abstract_inverted_index.not | 170 |
| abstract_inverted_index.our | 5, 32, 124 |
| abstract_inverted_index.the | 11, 20, 172, 175 |
| abstract_inverted_index.via | 97 |
| abstract_inverted_index.data | 121, 156 |
| abstract_inverted_index.does | 169 |
| abstract_inverted_index.drug | 177 |
| abstract_inverted_index.from | 133 |
| abstract_inverted_index.gene | 159 |
| abstract_inverted_index.high | 54, 147 |
| abstract_inverted_index.read | 28 |
| abstract_inverted_index.that | 52 |
| abstract_inverted_index.tool | 192 |
| abstract_inverted_index.with | 117, 135, 146, 150 |
| abstract_inverted_index.Here, | 41 |
| abstract_inverted_index.Rapid | 46 |
| abstract_inverted_index.SF3B1 | 129, 142, 163 |
| abstract_inverted_index.cDNA, | 110 |
| abstract_inverted_index.genes | 76, 130, 187 |
| abstract_inverted_index.makes | 188 |
| abstract_inverted_index.often | 24 |
| abstract_inverted_index.panel | 85 |
| abstract_inverted_index.probe | 84 |
| abstract_inverted_index.sets. | 122 |
| abstract_inverted_index.study | 182 |
| abstract_inverted_index.usage | 9, 74 |
| abstract_inverted_index.using | 62, 89 |
| abstract_inverted_index.which | 111 |
| abstract_inverted_index.(CLL), | 139 |
| abstract_inverted_index.Oxford | 98 |
| abstract_inverted_index.allows | 112 |
| abstract_inverted_index.cells, | 166 |
| abstract_inverted_index.cells. | 15 |
| abstract_inverted_index.detect | 141 |
| abstract_inverted_index.genes. | 40 |
| abstract_inverted_index.impact | 171 |
| abstract_inverted_index.method | 51, 80 |
| abstract_inverted_index.status | 71 |
| abstract_inverted_index.stored | 106 |
| abstract_inverted_index.Capture | 47 |
| abstract_inverted_index.Despite | 16 |
| abstract_inverted_index.RNA-seq | 120 |
| abstract_inverted_index.ability | 33 |
| abstract_inverted_index.between | 14 |
| abstract_inverted_index.calling | 37 |
| abstract_inverted_index.chronic | 136 |
| abstract_inverted_index.indexed | 108 |
| abstract_inverted_index.isoform | 8 |
| abstract_inverted_index.perform | 35 |
| abstract_inverted_index.pooling | 93 |
| abstract_inverted_index.primers | 91 |
| abstract_inverted_index.results | 25 |
| abstract_inverted_index.reveals | 157 |
| abstract_inverted_index.samples | 132 |
| abstract_inverted_index.thereby | 30 |
| abstract_inverted_index.-mutated | 164 |
| abstract_inverted_index.Nanopore | 99 |
| abstract_inverted_index.allowing | 65 |
| abstract_inverted_index.although | 167 |
| abstract_inverted_index.analysis | 68, 113 |
| abstract_inverted_index.barcoded | 90 |
| abstract_inverted_index.capture, | 88 |
| abstract_inverted_index.combined | 116 |
| abstract_inverted_index.creating | 82 |
| abstract_inverted_index.existing | 118 |
| abstract_inverted_index.in-depth | 18, 67 |
| abstract_inverted_index.includes | 81 |
| abstract_inverted_index.isoforms | 143 |
| abstract_inverted_index.leukemia | 138 |
| abstract_inverted_index.limiting | 31 |
| abstract_inverted_index.multiple | 186 |
| abstract_inverted_index.mutation | 12, 36, 70 |
| abstract_inverted_index.patients | 134 |
| abstract_inverted_index.powerful | 191 |
| abstract_inverted_index.specific | 39 |
| abstract_inverted_index.targeted | 60 |
| abstract_inverted_index.unbiased | 17 |
| abstract_inverted_index.analysis, | 19 |
| abstract_inverted_index.capturing | 59 |
| abstract_inverted_index.coverage, | 29 |
| abstract_inverted_index.developed | 43 |
| abstract_inverted_index.efficient | 95 |
| abstract_inverted_index.genomics. | 195 |
| abstract_inverted_index.interest. | 78 |
| abstract_inverted_index.long-read | 1, 63, 183 |
| abstract_inverted_index.mutations | 145 |
| abstract_inverted_index.anticancer | 176 |
| abstract_inverted_index.applicable | 104 |
| abstract_inverted_index.capability | 180 |
| abstract_inverted_index.efficiency | 57 |
| abstract_inverted_index.expression | 160 |
| abstract_inverted_index.platforms. | 101 |
| abstract_inverted_index.scRaCH-seq | 102 |
| abstract_inverted_index.sequencing | 2, 22, 49, 96, 154 |
| abstract_inverted_index.short-read | 119, 151 |
| abstract_inverted_index.throughput | 23 |
| abstract_inverted_index.transcript | 73, 87 |
| abstract_inverted_index.(scRNA-seq) | 155 |
| abstract_inverted_index.Integration | 149 |
| abstract_inverted_index.Single-cell | 0 |
| abstract_inverted_index.differences | 161 |
| abstract_inverted_index.lymphocytic | 137 |
| abstract_inverted_index.sensitivity | 173 |
| abstract_inverted_index.sequencing, | 64 |
| abstract_inverted_index.significant | 158 |
| abstract_inverted_index.single-cell | 45, 109, 152, 194 |
| abstract_inverted_index.specificity | 55 |
| abstract_inverted_index.transcripts | 61, 184 |
| abstract_inverted_index.transformed | 4 |
| abstract_inverted_index.venetoclax. | 178 |
| abstract_inverted_index.(scRaCH-seq) | 50 |
| abstract_inverted_index.Technologies | 100 |
| abstract_inverted_index.demonstrates | 53 |
| abstract_inverted_index.insufficient | 27 |
| abstract_inverted_index.scRaCH-seq's | 179 |
| abstract_inverted_index.sensitivity. | 148 |
| abstract_inverted_index.Hybridization | 48 |
| abstract_inverted_index.heterogeneity | 13 |
| abstract_inverted_index.investigation | 125 |
| abstract_inverted_index.understanding | 6 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.550000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96235647 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |