Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome Article Swipe
Emilie Pollenus
,
Hendrik Possemiers
,
Sofie Knoops
,
Fran Prenen
,
Leen Vandermosten
,
Chloë Thienpont
,
Saeed Abdurahiman
,
Sofie Demeyer
,
Jan Cools
,
Gianluca Matteoli
,
Jeroen Vanoirbeek
,
Greetje Vande Velde
,
Philippe E. Van den Steen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.ppat.1011929
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.ppat.1011929
Plasmodium parasites cause malaria, a global health disease that is responsible for more than 200 million clinical cases and 600 000 deaths each year. Most deaths are caused by various complications, including malaria-associated acute respiratory distress syndrome (MA-ARDS). Despite the very rapid and efficient killing of parasites with antimalarial drugs, 15% of patients with complicated malaria succumb. This stresses the importance of investigating resolution mechanisms that are involved in the recovery from these complications once the parasite is killed. To study the resolution of MA-ARDS, P . berghei NK65-infected C57BL/6 mice were treated with antimalarial drugs after onset of symptoms, resulting in 80% survival. Micro-computed tomography revealed alterations of the lungs upon infection, with an increase in total and non-aerated lung volume due to edema. Whole body plethysmography confirmed a drastically altered lung ventilation, which was restored during resolution. Single-cell RNA sequencing indicated an increased inflammatory state in the lungs upon infection, which was accompanied by a drastic decrease in endothelial cells, consistent with CD8 + T cell-mediated killing. During resolution, anti-inflammatory pathways were upregulated and proliferation of endothelial cells was observed. MultiNicheNet interactome analysis identified important changes in the ligand-receptor interactions during disease resolution that warrant further exploration in order to develop new therapeutic strategies. In conclusion, our study provides insights in pro-resolving pathways that limit inflammation and promote endothelial cell proliferation in experimental MA-ARDS. This information may be useful for the design of adjunctive treatments to enhance resolution after Plasmodium parasite killing by antimalarial drugs.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.ppat.1011929
- https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011929&type=printable
- OA Status
- gold
- Cited By
- 8
- References
- 105
- Related Works
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- OpenAlex ID
- https://openalex.org/W4390967891
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390967891Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.ppat.1011929Digital Object Identifier
- Title
-
Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndromeWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-18Full publication date if available
- Authors
-
Emilie Pollenus, Hendrik Possemiers, Sofie Knoops, Fran Prenen, Leen Vandermosten, Chloë Thienpont, Saeed Abdurahiman, Sofie Demeyer, Jan Cools, Gianluca Matteoli, Jeroen Vanoirbeek, Greetje Vande Velde, Philippe E. Van den SteenList of authors in order
- Landing page
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https://doi.org/10.1371/journal.ppat.1011929Publisher landing page
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011929&type=printableDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011929&type=printableDirect OA link when available
- Concepts
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Malaria, Acute respiratory distress, Cell, Biology, RNA, Immunology, Computational biology, Virology, Medicine, Genetics, Lung, Gene, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
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-
2025: 6, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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105Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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