Single-Cell RNA Transcriptomics Reveals the State of Hepatic Lymphatic Endothelial Cells in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure Article Swipe
Pengpeng Zhang
,
Hao Li
,
Chen Zhou
,
Kai Liu
,
Bo Peng
,
Xingguo She
,
Ke Cheng
,
Hong Liu
,
Yingzi Ming
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jcm11102910
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jcm11102910
Acute-on-chronic liver failure (ACLF) is an acutely decompensated cirrhosis syndrome with high short-term mortality. Very little is known about the relationship between the lymphatic system and ACLF. We explored the role of hepatic lymphatic vessels (LVs) and lymphatic endothelial cells (LyECs) in ACLF using human liver samples with the help of single-cell RNA-sequencing (scRNA-seq) technology. Here, ACLF exhibited more severe liver injury and inflammation than cirrhosis, as indicated by significant increases in plasma levels of alanine/aspartate aminotransferases and total bilirubin. Compared with cirrhosis cases, the number of intrahepatic LVs was decreased significantly in ACLF patients. ScRNA-seq revealed that many monocyte/macrophages infiltrated into the liver of ACLF cases. Meanwhile, scRNA-seq revealed a group of apoptotic and dysfunctional LyECs, which were the result of secreted phosphoprotein 1 (SPP1) released from infiltrating monocyte/macrophages. In vitro, SPP1 increased the proportion of dead LyECs significantly and impaired the ability of tube formation of LyECs in a dose- and time-dependent manner. In conclusion, ACLF is associated with less LV and LyEC dysfunction, at least in part mediated by SPP1 released from infiltrating monocyte/macrophages. Hepatic LVs and LyECs can be a novel therapeutic strategy for ACLF.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm11102910
- https://www.mdpi.com/2077-0383/11/10/2910/pdf?version=1653298909
- OA Status
- gold
- Cited By
- 17
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4280597960
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4280597960Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm11102910Digital Object Identifier
- Title
-
Single-Cell RNA Transcriptomics Reveals the State of Hepatic Lymphatic Endothelial Cells in Hepatitis B Virus-Related Acute-on-Chronic Liver FailureWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-05-20Full publication date if available
- Authors
-
Pengpeng Zhang, Hao Li, Chen Zhou, Kai Liu, Bo Peng, Xingguo She, Ke Cheng, Hong Liu, Yingzi MingList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm11102910Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/11/10/2910/pdf?version=1653298909Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2077-0383/11/10/2910/pdf?version=1653298909Direct OA link when available
- Concepts
-
Cirrhosis, Medicine, Lymphatic system, Monocyte, Inflammation, Hepatic stellate cell, Pathology, Immunology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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17Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 2, 2023: 9, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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