Single-cell sequencing reveals psilocybin induces sustained cell-type specific plasticity in mouse medial prefrontal cortex Article Swipe
Delong Zhou
,
Heike Schuler
,
Vedrana Cvetkovska
,
Juliet Meccia
,
Ashot S. Harutyunyan
,
Jiannis Ragoussis
,
Rosemary C. Bagot
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.01.08.631940
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.01.08.631940
SUMMARY The ever-increasing burden of psychiatric disorders and limitations of current treatments have fueled enormous interest in the therapeutic potential of psychedelics. Yet how psychedelics, such as psilocybin, produce lasting therapeutic effects is unclear. Using scRNA-sequencing we identify a type of deep layer near projecting neuron that is most robustly regulated in the medial prefrontal cortex of female mice 24h after psilocybin. We show that this cell-type specificity does not align with 5-HT 2A receptor expression but is consistent with the integrated signaling via cell-type specific 5-HT receptor co-expression patterns. Cell-cell communication reveals that psilocybin also broadly suppresses GABAergic inhibition. Ultimately, psilocybin induces plasticity-related genes in subsets of excitatory neurons suggesting that psilocybin induces sustained increases in neuroplasticity in the mouse mPFC. Our findings point to L5/6NP neurons as a key mediator of psilocybin’s neuroplastic effects.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.01.08.631940
- OA Status
- green
- Cited By
- 2
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406168575
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406168575Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.01.08.631940Digital Object Identifier
- Title
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Single-cell sequencing reveals psilocybin induces sustained cell-type specific plasticity in mouse medial prefrontal cortexWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-08Full publication date if available
- Authors
-
Delong Zhou, Heike Schuler, Vedrana Cvetkovska, Juliet Meccia, Ashot S. Harutyunyan, Jiannis Ragoussis, Rosemary C. BagotList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.01.08.631940Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.1101/2025.01.08.631940Direct OA link when available
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Psilocybin, Prefrontal cortex, Neuroscience, Neuroplasticity, Cell type, Plasticity, Cell, Biology, Hallucinogen, Cognition, Genetics, Materials science, Pharmacology, Composite materialTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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65Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.subsets | 106 |
| abstract_inverted_index.effects. | 135 |
| abstract_inverted_index.enormous | 14 |
| abstract_inverted_index.findings | 123 |
| abstract_inverted_index.identify | 37 |
| abstract_inverted_index.interest | 15 |
| abstract_inverted_index.mediator | 131 |
| abstract_inverted_index.receptor | 74, 87 |
| abstract_inverted_index.robustly | 49 |
| abstract_inverted_index.specific | 85 |
| abstract_inverted_index.unclear. | 33 |
| abstract_inverted_index.Cell-cell | 90 |
| abstract_inverted_index.GABAergic | 98 |
| abstract_inverted_index.cell-type | 66, 84 |
| abstract_inverted_index.disorders | 6 |
| abstract_inverted_index.increases | 115 |
| abstract_inverted_index.patterns. | 89 |
| abstract_inverted_index.potential | 19 |
| abstract_inverted_index.regulated | 50 |
| abstract_inverted_index.signaling | 82 |
| abstract_inverted_index.sustained | 114 |
| abstract_inverted_index.consistent | 78 |
| abstract_inverted_index.excitatory | 108 |
| abstract_inverted_index.expression | 75 |
| abstract_inverted_index.integrated | 81 |
| abstract_inverted_index.prefrontal | 54 |
| abstract_inverted_index.projecting | 44 |
| abstract_inverted_index.psilocybin | 94, 101, 112 |
| abstract_inverted_index.suggesting | 110 |
| abstract_inverted_index.suppresses | 97 |
| abstract_inverted_index.treatments | 11 |
| abstract_inverted_index.Ultimately, | 100 |
| abstract_inverted_index.inhibition. | 99 |
| abstract_inverted_index.limitations | 8 |
| abstract_inverted_index.psilocybin, | 27 |
| abstract_inverted_index.psilocybin. | 61 |
| abstract_inverted_index.psychiatric | 5 |
| abstract_inverted_index.specificity | 67 |
| abstract_inverted_index.therapeutic | 18, 30 |
| abstract_inverted_index.neuroplastic | 134 |
| abstract_inverted_index.co-expression | 88 |
| abstract_inverted_index.communication | 91 |
| abstract_inverted_index.psychedelics, | 24 |
| abstract_inverted_index.psychedelics. | 21 |
| abstract_inverted_index.psilocybin’s | 133 |
| abstract_inverted_index.ever-increasing | 2 |
| abstract_inverted_index.neuroplasticity | 117 |
| abstract_inverted_index.scRNA-sequencing | 35 |
| abstract_inverted_index.plasticity-related | 103 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.94315613 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |