Single-Cell Transcriptomic Analysis Links Nonmyelinating Schwann Cells to Proinflammatory Response in the Lung Article Swipe
Jose E. Heredia
,
Min Jung
,
Alessia Balestrini
,
Jonas Doerr
,
Andrés Paler-Martı́nez
,
Alessandro M. Mozzarelli
,
Lorena Riol‐Blanco
,
Joshua S. Kaminker
,
Ning Ding
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.2200946
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.2200946
The lung is a barrier tissue with constant exposure to the inhaled environment. Therefore, innate immunity against particulates and pathogens is of critical importance to maintain tissue homeostasis. Although the lung harbors both myelinating and nonmyelinating Schwann cells (NMSCs), NMSCs represent the most abundant Schwann cell (SC) population in the lung. However, their contribution to lung physiology remains largely unknown. In this study, we used the human glial fibrillary acidic protein promoter driving tdTomato expression in mice to identify SCs in the peripheral nervous system and determine their location within the lung. Single-cell transcriptomic analysis revealed the existence of two NMSC populations (NMSC1 and NMSC2) that may participate in pathogen recognition. We demonstrated that these pulmonary SCs produce chemokines and cytokines upon LPS stimulation using in vitro conditions. Furthermore, we challenged mouse lungs with LPS and found that NMSC1 exhibits an enriched proinflammatory response among all SC subtypes. Collectively, these findings define the molecular profiles of lung SCs and suggest a potential role for NMSCs in lung inflammation.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4049/jimmunol.2200946
- https://journals.aai.org/jimmunol/article-pdf/211/5/844/1638663/ji2200946.pdf
- OA Status
- bronze
- Cited By
- 4
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384925404
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4384925404Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4049/jimmunol.2200946Digital Object Identifier
- Title
-
Single-Cell Transcriptomic Analysis Links Nonmyelinating Schwann Cells to Proinflammatory Response in the LungWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-21Full publication date if available
- Authors
-
Jose E. Heredia, Min Jung, Alessia Balestrini, Jonas Doerr, Andrés Paler-Martı́nez, Alessandro M. Mozzarelli, Lorena Riol‐Blanco, Joshua S. Kaminker, Ning DingList of authors in order
- Landing page
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https://doi.org/10.4049/jimmunol.2200946Publisher landing page
- PDF URL
-
https://journals.aai.org/jimmunol/article-pdf/211/5/844/1638663/ji2200946.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://journals.aai.org/jimmunol/article-pdf/211/5/844/1638663/ji2200946.pdfDirect OA link when available
- Concepts
-
Proinflammatory cytokine, Chemokine, Biology, Transcriptome, Lung, Cell biology, Inflammation, Schwann cell, Immunology, Innate immune system, CCL2, Population, Neuroscience, Immune system, Medicine, Gene expression, Genetics, Internal medicine, Gene, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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