Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord Article Swipe
John F. Tuddenham
,
Masashi Fujita
,
Anthony Khairallah
,
Claire Harbison
,
Xena Flowers
,
Guillermo Coronas‐Samano
,
Silas Maniatis
,
Aidan C. Daly
,
Julie A. Schneider
,
Andrew F. Teich
,
Jean Paul G. Vonsattel
,
Peter A. Sims
,
Wassim Elyaman
,
Elizabeth M. Bradshaw
,
Hemali Phatnani
,
Neil A. Shneider
,
David A. Bennett
,
Philip L. De Jager
,
Serge Przedborski
,
Vilas Menon
,
Marta Olah
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.11.12.623183
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.11.12.623183
Development of therapeutic approaches that target specific microglia responses in amyotrophic lateral sclerosis (ALS) is crucial due to the involvement of microglia in ALS progression. Our study identifies the predominant microglia subset in human ALS primary motor cortex and spinal cord as an undifferentiated phenotype with dysregulated respiratory electron transport. Moreover, we find that the interferon response microglia subset is enriched in donors with aggressive disease progression, while a previously described potentially protective microglia phenotype is depleted in ALS. Additionally, we observe an enrichment of non-microglial immune cell, mainly NK/T cells, in ALS central nervous system, primarily in the spinal cord. These findings pave the way for the development of microglia subset-specific therapeutic interventions to slow or even stop ALS progression.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.11.12.623183
- https://www.biorxiv.org/content/biorxiv/early/2024/11/14/2024.11.12.623183.full.pdf
- OA Status
- green
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404371838
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4404371838Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.11.12.623183Digital Object Identifier
- Title
-
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cordWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-14Full publication date if available
- Authors
-
John F. Tuddenham, Masashi Fujita, Anthony Khairallah, Claire Harbison, Xena Flowers, Guillermo Coronas‐Samano, Silas Maniatis, Aidan C. Daly, Julie A. Schneider, Andrew F. Teich, Jean Paul G. Vonsattel, Peter A. Sims, Wassim Elyaman, Elizabeth M. Bradshaw, Hemali Phatnani, Neil A. Shneider, David A. Bennett, Philip L. De Jager, Serge Przedborski, Vilas Menon, Marta OlahList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.11.12.623183Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2024/11/14/2024.11.12.623183.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2024/11/14/2024.11.12.623183.full.pdfDirect OA link when available
- Concepts
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Microglia, Amyotrophic lateral sclerosis, Spinal cord, Neuroscience, Central nervous system, Multiple sclerosis, Immune system, Phenotype, Biology, Medicine, Immunology, Inflammation, Disease, Pathology, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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47Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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