Single-oocyte transcriptional profile of early-stage human oocytes reveals differentially expressed genes in the primordial and transitioning stages Article Swipe
Ariella Shikanov
,
Jordan H. Machlin
,
D. Ford Hannum
,
Andrea Jones
,
Taylor Schissel
,
Kate Potocsky
,
Erica E. Marsh
,
Saher Sue Hammoud
,
Vasantha Padmanabhan
,
Jun Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6957514/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6957514/v1
The critical initial step in human oocyte maturation - the transition of ovarian follicles from dormancy to activation - remains poorly understood. Here we performed RNA sequencing on single oocytes isolated from early-stage follicles from nine healthy reproductive-age donors. Data for 133 high-quality oocytes formed two connected clusters, C1 and C2, with 5,449 significantly differentially expressed genes. Using recently reported gene lists for early-stage follicles we found that C1 oocytes likely came from earlier, dormant primordial follicles, while C2 oocytes match later-stage primordial or transitioning follicles. We sought to validate two DE genes, UHRF1 for C1 and CCN2 for C2, by their RNA-FISH in situ pattern in morphologically classified follicles, but did not observe statistically significant differences between follicle stages. This apparent discrepancy between follicle’s stage determined by its morphology and oocyte’s transcriptional state, if replicated in additional studies, may indicate a lack of closely coupled synchrony between follicle morphology and oocyte’s functional state.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-6957514/v1
- https://www.researchsquare.com/article/rs-6957514/latest.pdf
- OA Status
- gold
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412011385
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412011385Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-6957514/v1Digital Object Identifier
- Title
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Single-oocyte transcriptional profile of early-stage human oocytes reveals differentially expressed genes in the primordial and transitioning stagesWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-03Full publication date if available
- Authors
-
Ariella Shikanov, Jordan H. Machlin, D. Ford Hannum, Andrea Jones, Taylor Schissel, Kate Potocsky, Erica E. Marsh, Saher Sue Hammoud, Vasantha Padmanabhan, Jun LiList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-6957514/v1Publisher landing page
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https://www.researchsquare.com/article/rs-6957514/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-6957514/latest.pdfDirect OA link when available
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Oocyte, Biology, Gene, Stage (stratigraphy), Cell biology, Genetics, Gene expression, Transcriptome, Computational biology, Andrology, Embryo, Medicine, PaleontologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2025-07-03 |
| publication_year | 2025 |
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