Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning Article Swipe
Aditi B. Buch
,
Ava L Shipman
,
Nicolas J. Azzarello
,
Annie W. Zhou
,
Samuel W. Centanni
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00213-025-06968-8
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00213-025-06968-8
Rationale & objective Exposure to traumatic stressors can have detrimental effects on one’s well-being. Alcohol is often used as a coping mechanism to alleviate stress, leading to the development of alcohol use disorder (AUD). Furthermore, sex dimorphisms in stress and AUD alter their progression and sustenance. To investigate these interactions for effective treatment strategies, validated and exhaustive preclinical models are necessary. Here, we designed a comprehensive study that examines how traumatic stress influences ethanol drinking patterns and PTSD-like phenotypes in male and female mice with Single Prolonged Stress (SPS). Methods Male and female C57BL/6 J mice underwent SPS, a model of traumatic stress consisting of a series of consecutive stressors, followed by a 7-day stress incubation period. Mice then underwent a series of tests for aversive state, fear discrimination, and drinking patterns during continuous and limited ethanol access. Results & conclusions SPS selectively increased negative affect and startle responses in male mice, while females were unaffected. SPS disrupted discrimination adjustment between fear and safety cues during extinction, while ethanol exposure attenuated overall fear responses. SPS maintained baseline sex differences in consumption. Furthermore, female consumption increased when access was provided prior to and continuously throughout SPS and fear conditioning, contrasting with groups exposed to ethanol afterwards. In summary, we identified a distinct sex specific relationship between traumatic stress, fear memory, and the timing of ethanol consumption. We highlight SPS as a robust translational model for exploring the sex-specific neurobiological mechanisms driving traumatic stress-induced affective disturbances.
Related Topics
Concepts
Stressor
Psychology
Alcohol
Ethanol
Alcohol use disorder
Alcohol consumption
Startle reaction
Affect (linguistics)
Sex characteristics
Traumatic stress
Clinical psychology
Poison control
Fear conditioning
Alcohol intoxication
Young adult
Coping (psychology)
Injury prevention
Fear-potentiated startle
Medicine
Stress (linguistics)
Startle response
Alcohol dependence
Animal model
Moro reflex
Excessive alcohol consumption
Physiology
Fight-or-flight response
Psychiatry
Adult male
Volunteer
Developmental psychology
Human factors and ergonomics
Analysis of variance
Phenotype
Mechanism (biology)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00213-025-06968-8
- https://link.springer.com/content/pdf/10.1007/s00213-025-06968-8.pdf
- OA Status
- hybrid
- References
- 81
- OpenAlex ID
- https://openalex.org/W7106577333
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106577333Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s00213-025-06968-8Digital Object Identifier
- Title
-
Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learningWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-24Full publication date if available
- Authors
-
Aditi B. Buch, Ava L Shipman, Nicolas J. Azzarello, Annie W. Zhou, Samuel W. CentanniList of authors in order
- Landing page
-
https://doi.org/10.1007/s00213-025-06968-8Publisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1007/s00213-025-06968-8.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://link.springer.com/content/pdf/10.1007/s00213-025-06968-8.pdfDirect OA link when available
- Concepts
-
Stressor, Psychology, Alcohol, Ethanol, Alcohol use disorder, Alcohol consumption, Startle reaction, Affect (linguistics), Sex characteristics, Traumatic stress, Clinical psychology, Poison control, Fear conditioning, Alcohol intoxication, Young adult, Coping (psychology), Injury prevention, Fear-potentiated startle, Medicine, Stress (linguistics), Startle response, Alcohol dependence, Animal model, Moro reflex, Excessive alcohol consumption, Physiology, Fight-or-flight response, Psychiatry, Adult male, Volunteer, Developmental psychology, Human factors and ergonomics, Analysis of variance, Phenotype, Mechanism (biology)Top concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
81Number of works referenced by this work
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| publication_date | 2025-11-24 |
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