Single-Stage Repair of Contaminated Hernias Using a Novel Antibiotic-Impregnated Biologic Porcine Submucosa Tissue Matrix Article Swipe
Samuel Minor
,
Carl J. Brown
,
Paul Rooney
,
Jason P. Hodde
,
Lisa Julien
,
Tracy Scott
,
Ahmer Karimuddin
,
Manoj J. Raval
,
Terry P Phang
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.2.14521/v2
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.2.14521/v2
Background Single-stage repair of incisional hernias in contaminated fields has a high rate of surgical site infection (30-42%) when biologic grafts are used for repair. In an attempt to decrease this risk, a novel graft incorporating gentamicin into a biologic extracellular matrix derived from porcine small intestine submucosa was developed. Methods This prospective, multicenter, single-arm study was designed to determine the incidence of surgical site infection following implantation of the device into surgical fields characterized as CDC Class II, III, or IV. Results Twenty-four patients were enrolled, with 42% contaminated and 25% dirty surgical fields. After 12 months, 5 patients experienced 6 surgical site infections (21%) with infection involving the graft in 2 patients (8%). No grafts were explanted. Conclusions The incorporation of gentamicin into a porcine-derived biologic graft is feasible and safe with a low rate of device infection for patients undergoing single-stage repair of ventral hernia in contaminated settings. Trial Registration The study was registered March 27, 2015 at www.clinicaltrials.gov as NCT02401334. Keywords Hernia repair; graft; abdominal wall reconstruction; contamination
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Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.2.14521/v2
- https://www.researchsquare.com/article/rs-5198/v2.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4252505466
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4252505466Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.2.14521/v2Digital Object Identifier
- Title
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Single-Stage Repair of Contaminated Hernias Using a Novel Antibiotic-Impregnated Biologic Porcine Submucosa Tissue MatrixWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-03Full publication date if available
- Authors
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Samuel Minor, Carl J. Brown, Paul Rooney, Jason P. Hodde, Lisa Julien, Tracy Scott, Ahmer Karimuddin, Manoj J. Raval, Terry P PhangList of authors in order
- Landing page
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https://doi.org/10.21203/rs.2.14521/v2Publisher landing page
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https://www.researchsquare.com/article/rs-5198/v2.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.researchsquare.com/article/rs-5198/v2.pdfDirect OA link when available
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Antibiotics, Submucosa, Stage (stratigraphy), Contamination, Matrix (chemical analysis), Medicine, Chemistry, Surgery, Microbiology, Biology, Chromatography, Ecology, PaleontologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2023: 1Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Single-stage | 2 |
| abstract_inverted_index.contaminated | 8, 90, 150 |
| abstract_inverted_index.implantation | 68 |
| abstract_inverted_index.multicenter, | 54 |
| abstract_inverted_index.prospective, | 53 |
| abstract_inverted_index.single-stage | 144 |
| abstract_inverted_index.characterized | 75 |
| abstract_inverted_index.contamination | 172 |
| abstract_inverted_index.extracellular | 41 |
| abstract_inverted_index.incorporating | 36 |
| abstract_inverted_index.incorporation | 122 |
| abstract_inverted_index.porcine-derived | 127 |
| abstract_inverted_index.reconstruction; | 171 |
| abstract_inverted_index.www.clinicaltrials.gov | 162 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.60108988 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |