Single‐cell transcriptomic analysis of the senescent microenvironment in bone metastasis Article Swipe
Shenglin Wang
,
Lu Ao
,
Huangfeng Lin
,
Hongxiang Wei
,
Zhaoyang Wu
,
Shuting Lu
,
Fude Liang
,
Rongkai Shen
,
Huarong Zhang
,
T G Miao
,
Xiaopei Shen
,
Jianhua Lin
,
Guang‐Xian Zhong
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/cpr.13743
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/cpr.13743
Bone metastasis (BM) is a mortality‐related event of late‐stage cancer, with non‐small cell lung cancer (NSCLC) being a common origin for BM. However, the detailed molecular profiling of the metastatic bone ecosystem is not fully understood, hindering the development of effective therapies for advanced patients. In this study, we examined the cellular heterogeneity between primary tumours and BM from tissues and peripheral blood by single‐cell transcriptomic analysis, which was verified using multiplex immunofluorescence staining and public datasets. Our results demonstrate a senescent microenvironment in BM tissues of NSCLC. BM has a significantly higher infiltration of malignant cells with senescent characteristics relative to primary tumours, accompanied by aggravated metastatic properties. The endothelial‐mesenchymal transition involved with SOX18 activation is related to the cellular senescence of vascular endothelial cells from BM. CD4Tstr cells, with pronounced stress and senescence states, are preferentially infiltrated in BM, indicating stress‐related dysfunction contributing to the immunocompromised environment during tumour metastasis to bone. Moreover, we identify the SPP1 pathway‐induced cellular crosstalk among T cells, vascular ECs and malignant cells in BM, which activates SOX18 and deteriorates patient survival. Our findings highlight the roles of cellular senescence in modulating the microenvironment of BM and implicate anti‐senescence therapy for advanced NSCLC patients.
Related Topics
Concepts
Bone metastasis
Metastasis
Transcriptome
Cell
Biology
Cell biology
Cancer research
Cancer
Genetics
Gene expression
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/cpr.13743
- OA Status
- gold
- Cited By
- 4
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402287614
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402287614Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/cpr.13743Digital Object Identifier
- Title
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Single‐cell transcriptomic analysis of the senescent microenvironment in bone metastasisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-04Full publication date if available
- Authors
-
Shenglin Wang, Lu Ao, Huangfeng Lin, Hongxiang Wei, Zhaoyang Wu, Shuting Lu, Fude Liang, Rongkai Shen, Huarong Zhang, T G Miao, Xiaopei Shen, Jianhua Lin, Guang‐Xian ZhongList of authors in order
- Landing page
-
https://doi.org/10.1111/cpr.13743Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1111/cpr.13743Direct OA link when available
- Concepts
-
Bone metastasis, Metastasis, Transcriptome, Cell, Biology, Cell biology, Cancer research, Cancer, Genetics, Gene expression, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
- References (count)
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62Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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