SIRT1: potential target in glucocorticoid-resistant diseases Article Swipe
Jun Xie
,
Siyi Che
,
Jiao Liu
,
Xiaoru Long
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2025.1514745
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2025.1514745
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases. In steroid-resistant airway inflammatory diseases, glucocorticoid receptor (GR) expression is reduced, and impaired GR nuclear translocation is closely related to glucocorticoid resistance. Histone deacetylase SIRT1 regulates steroid hormone receptor activity and interacts with the androgen receptor and GR. In some glucocorticoid-resistant diseases, SIRT1 expression is reduced. Here, we review recent advances in the role of SIRT1 in regulating glucocorticoid signaling. First, we describe the structure, tissue expression, and subcellular localization of SIRT1. We also discuss the molecular mechanisms by which SIRT1 regulates glucocorticoid activity and its association with GR, as well as the mechanisms and roles of SIRT1 in several common glucocorticoid-resistant diseases. SIRT1 may serve as a potential therapeutic target, providing an opportunity for the treatment of glucocorticoid-resistant diseases.
Related Topics
Concepts
Glucocorticoid
Glucocorticoid receptor
Nuclear receptor
Histone deacetylase
Biology
Nuclear receptor coactivator 2
Histone
Endocrinology
Transcription factor
Genetics
Gene
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2025.1514745
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1514745/pdf
- OA Status
- gold
- Cited By
- 1
- References
- 77
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410248393
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410248393Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2025.1514745Digital Object Identifier
- Title
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SIRT1: potential target in glucocorticoid-resistant diseasesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-09Full publication date if available
- Authors
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Jun Xie, Siyi Che, Jiao Liu, Xiaoru LongList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2025.1514745Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1514745/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1514745/pdfDirect OA link when available
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Glucocorticoid, Glucocorticoid receptor, Nuclear receptor, Histone deacetylase, Biology, Nuclear receptor coactivator 2, Histone, Endocrinology, Transcription factor, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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77Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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