Site-selective introduction of thiols in unprotected glycosides Article Swipe
Related Concepts
Chemistry
Protecting group
Glycosyl
Thiol
Glycosylation
Moiety
Hydrazone
Glycoside
Combinatorial chemistry
Organic chemistry
Stereochemistry
Biochemistry
Alkyl
Niels R. M. Reintjens
,
Martin D. Witte
,
Adriaan J. Minnaard
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1039/d3ob00817g
· OA: W4379231947
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1039/d3ob00817g
· OA: W4379231947
Site-selective oxidation of unprotected saccharides, followed by treatment of the corresponding trityl hydrazone with t -Bu hypochlorite, gives a chloro-azo intermediate that can be substituted to give deoxythio sugars. This allows a protecting group-free synthesis of thioglycosides.
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