Size-Based Separation of Particles and Cells Utilizing Viscoelastic Effects in Straight Microchannels Article Swipe

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Chao Liu , Chun‐Dong Xue , Xiaohong Chen , Lei Shan , Yu Tian , Guoqing Hu ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1021/acs.analchem.5b00516

Viscoelasticity-induced particle migration has recently received increasing attention due to its ability to obtain high-quality focusing over a wide range of flow rates. However, its application is limited to low throughput regime since the particles can defocus as flow rate increases. Using an engineered carrier medium with constant and low viscosity and strong elasticity, the sample flow rates are improved to be 1 order of magnitude higher than those in existing studies. Utilizing differential focusing of particles of different sizes, here, we present sheathless particle/cell separation in simple straight microchannels that possess excellent parallelizability for further throughput enhancement. The present method can be implemented over a wide range of particle/cell sizes and flow rates. We successfully separate small particles from larger particles, MCF-7 cells from red blood cells (RBCs), and Escherichia coli (E. coli) bacteria from RBCs in different straight microchannels. The proposed method could broaden the applications of viscoelastic microfluidic devices to particle/cell separation due to the enhanced sample throughput and simple channel design.

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Viscoelasticity Microfluidics Chemistry Particle (ecology) Particle size Volumetric flow rate Viscosity Nanotechnology Throughput Elasticity (physics) Range (aeronautics) Chromatography Mechanics Materials science Composite material Computer science Wireless Physical chemistry Geology Telecommunications Physics Oceanography

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Type: article
Language: en
Landing Page: https://doi.org/10.1021/acs.analchem.5b00516
OA Status: green
Cited By: 167
References: 65
Related Works: 10
OpenAlex ID: https://openalex.org/W2271628700

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OpenAlex ID: https://openalex.org/W2271628700

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DOI: https://doi.org/10.1021/acs.analchem.5b00516

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Title: Size-Based Separation of Particles and Cells Utilizing Viscoelastic Effects in Straight Microchannels

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Type: article

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Language: en

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Publication year: 2015

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Publication date: 2015-05-19

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Authors: Chao Liu, Chun‐Dong Xue, Xiaohong Chen, Lei Shan, Yu Tian, Guoqing Hu

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Landing page: https://doi.org/10.1021/acs.analchem.5b00516

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Open access: Yes

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OA status: green

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OA URL: https://dspace.imech.ac.cn/handle/311007/52049

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Concepts: Viscoelasticity, Microfluidics, Chemistry, Particle (ecology), Particle size, Volumetric flow rate, Viscosity, Nanotechnology, Throughput, Elasticity (physics), Range (aeronautics), Chromatography, Mechanics, Materials science, Composite material, Computer science, Wireless, Physical chemistry, Geology, Telecommunications, Physics, Oceanography

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Cited by: 167

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Citations by year (recent): 2025: 12, 2024: 18, 2023: 15, 2022: 19, 2021: 10

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References (count): 65

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