Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate Article Swipe
Feng Li
,
Yan Chen
,
Shubo Liu
,
Jian Quan Qi
,
Weiying Wang
,
Chenhua Wang
,
Ruiyue Zhong
,
Zhijun Chen
,
Xiaoming Li
,
Yuanzhou Guan
,
Wei Kong
,
Yong Zhang
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.2147/ijn.s143733
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.2147/ijn.s143733
Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, the fabrication of size-controlled zein particles has been a challenging issue. In this study, a modified anti-solvent precipitation method was developed, and the effects of various factors, such as mixing method, solvent/anti-solvent ratio, temperature, zein concentrations and the presence of sodium caseinate (SC) on properties of zein particles were investigated. Evidence is presented that, among the previously mentioned factors, the mixing method, especially mixing rate, could be used as an effective parameter to control the size of zein particles without changing other parameters. Moreover, through fine-tuning the mixing rate together with zein concentration, particles with sizes ranging from nanometers to micrometers and low polydispersity index values could be easily obtained. Based on the size-controlled fabrication method, SC-coated zein nanoparticles could also be obtained in a size-controlled manner by incubation of the coating material with the already-formed zein particles. The resultant nanoparticles showed better performance in both drug loading and controlled release, compared with zein/SC hybrid nanoparticles fabricated by adding aqueous ethanol solution to SC solution. The possible mechanisms of the nanoprecipitation process and self-assembly formation of these nanoparticles are discussed.
Related Topics
Concepts
Dispersity
Nanoparticle
Materials science
Chemical engineering
Solvent
Fabrication
Aqueous solution
Particle size
Mixing (physics)
Microparticle
Precipitation
Nanotechnology
Nanometre
Chemistry
Polymer chemistry
Organic chemistry
Composite material
Meteorology
Alternative medicine
Physics
Pathology
Engineering
Quantum mechanics
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2147/ijn.s143733
- https://www.dovepress.com/getfile.php?fileID=39272
- OA Status
- gold
- Cited By
- 52
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2767572091
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2767572091Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2147/ijn.s143733Digital Object Identifier
- Title
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Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinateWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-11-01Full publication date if available
- Authors
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Feng Li, Yan Chen, Shubo Liu, Jian Quan Qi, Weiying Wang, Chenhua Wang, Ruiyue Zhong, Zhijun Chen, Xiaoming Li, Yuanzhou Guan, Wei Kong, Yong ZhangList of authors in order
- Landing page
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https://doi.org/10.2147/ijn.s143733Publisher landing page
- PDF URL
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https://www.dovepress.com/getfile.php?fileID=39272Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.dovepress.com/getfile.php?fileID=39272Direct OA link when available
- Concepts
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Dispersity, Nanoparticle, Materials science, Chemical engineering, Solvent, Fabrication, Aqueous solution, Particle size, Mixing (physics), Microparticle, Precipitation, Nanotechnology, Nanometre, Chemistry, Polymer chemistry, Organic chemistry, Composite material, Meteorology, Alternative medicine, Physics, Pathology, Engineering, Quantum mechanics, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
52Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9, 2024: 5, 2023: 8, 2022: 7, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.properties | 63 |
| abstract_inverted_index.challenging | 28 |
| abstract_inverted_index.fabrication | 20, 133 |
| abstract_inverted_index.fine-tuning | 104 |
| abstract_inverted_index.micrometers | 119 |
| abstract_inverted_index.parameters. | 101 |
| abstract_inverted_index.performance | 162 |
| abstract_inverted_index.anti-solvent | 35 |
| abstract_inverted_index.demonstrated | 4 |
| abstract_inverted_index.temperature, | 52 |
| abstract_inverted_index.applications. | 17 |
| abstract_inverted_index.investigated. | 68 |
| abstract_inverted_index.nanoparticles | 137, 159, 174, 196 |
| abstract_inverted_index.precipitation | 36 |
| abstract_inverted_index.self-assembly | 192 |
| abstract_inverted_index.already-formed | 154 |
| abstract_inverted_index.concentration, | 111 |
| abstract_inverted_index.concentrations | 54 |
| abstract_inverted_index.polydispersity | 122 |
| abstract_inverted_index.size-controlled | 22, 132, 144 |
| abstract_inverted_index.nanoprecipitation | 189 |
| abstract_inverted_index.nano/microparticles | 1 |
| abstract_inverted_index.solvent/anti-solvent | 50 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5100419716 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I194450716 |
| citation_normalized_percentile.value | 0.86004611 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |