SLC1A5 Silencing Inhibits Esophageal Cancer Growth via Cell Cycle Arrest and Apoptosis Article Swipe
Jieping Lin
,
Teng Yang
,
Peng Zheng
,
Haiyan Xiao
,
Na Jiang
,
Lifang Zhang
,
Dickerson CA
,
Ping Wu
,
Qingjun Pan
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1159/000491769
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1159/000491769
Background/Aims: Solute-linked carrier family A1 member 5 (SLC1A5), which has high affinity to neutral amino acids, is essential for glutamine transport and amino acid metabolism in various cancers. However, the role of SLC1A5 in esophageal cancer has not been reported. Methods: SLC1A5 expression in esophageal cancer tissues was detected by immunohistochemistry and western blotting. The effects of SLC1A5 knockdown on the growth, cell cycle, viability, and glutamine metabolism of esophageal cancer cells were investigated with flow cytometry and western blotting. Furthermore, the consequences of SLC1A5 knockdown on tumor growth and survival were also evaluated in vivo using mice carrying esophageal cancer xenografts. Results: SLC1A5 was expressed in 86.5% (32/37) of the cancer tissues from esophageal cancer patients. Moreover, SLC1A5 expression in the cancerous tissues was significantly higher than that in the paired adjacent normal tissues. SLC1A5 knockdown with siRNA (PZ siRNA) in TE-1 cells in vitro significantly decreased cell growth and reduced both leucine and glutamine transport, leading to inhibition of mTORC1 signaling. Additionally, siRNA-mediated SLC1A5 knockdown resulted in cell cycle arrest and apoptosis of TE-1 cells. The survival rate of athymic (nu/nu) male nude mice carrying tumors formed from TE-1 cells transfected with SLC1A5 siRNA (PZ siRNA) was also significantly improved compared with mice carrying tumors formed from TE-1 cells transfected with control siRNA. Tumor size/weight was also significantly lower for the former mice group of mice. Conclusion: Our data indicate that SLC1A5 plays an important role in esophageal cancer both in vivo and in vitro. The inhibition of esophageal cancer growth by targeting SLC1A5 could, therefore, be used as a preoperative therapy for esophageal cancer.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1159/000491769
- https://www.karger.com/Article/Pdf/491769
- OA Status
- gold
- Cited By
- 48
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2885839062
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2885839062Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1159/000491769Digital Object Identifier
- Title
-
SLC1A5 Silencing Inhibits Esophageal Cancer Growth via Cell Cycle Arrest and ApoptosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-01-01Full publication date if available
- Authors
-
Jieping Lin, Teng Yang, Peng Zheng, Haiyan Xiao, Na Jiang, Lifang Zhang, Dickerson CA, Ping Wu, Qingjun PanList of authors in order
- Landing page
-
https://doi.org/10.1159/000491769Publisher landing page
- PDF URL
-
https://www.karger.com/Article/Pdf/491769Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.karger.com/Article/Pdf/491769Direct OA link when available
- Concepts
-
Gene knockdown, Glutamine, Apoptosis, Transfection, Cancer research, Programmed cell death, Cancer cell, Esophageal cancer, Cancer, Cell growth, Cell cycle, Chemistry, Biology, Cell culture, Amino acid, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
48Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 9, 2023: 9, 2022: 15, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.formed | 188, 207 |
| abstract_inverted_index.former | 223 |
| abstract_inverted_index.growth | 88, 149, 252 |
| abstract_inverted_index.higher | 126 |
| abstract_inverted_index.mTORC1 | 161 |
| abstract_inverted_index.member | 5 |
| abstract_inverted_index.normal | 133 |
| abstract_inverted_index.paired | 131 |
| abstract_inverted_index.siRNA) | 140, 197 |
| abstract_inverted_index.siRNA. | 214 |
| abstract_inverted_index.tumors | 187, 206 |
| abstract_inverted_index.vitro. | 246 |
| abstract_inverted_index.(32/37) | 108 |
| abstract_inverted_index.(nu/nu) | 182 |
| abstract_inverted_index.athymic | 181 |
| abstract_inverted_index.cancer. | 266 |
| abstract_inverted_index.carrier | 2 |
| abstract_inverted_index.control | 213 |
| abstract_inverted_index.effects | 55 |
| abstract_inverted_index.growth, | 61 |
| abstract_inverted_index.leading | 157 |
| abstract_inverted_index.leucine | 153 |
| abstract_inverted_index.neutral | 13 |
| abstract_inverted_index.reduced | 151 |
| abstract_inverted_index.therapy | 263 |
| abstract_inverted_index.tissues | 46, 112, 123 |
| abstract_inverted_index.various | 26 |
| abstract_inverted_index.western | 52, 78 |
| abstract_inverted_index.However, | 28 |
| abstract_inverted_index.Methods: | 40 |
| abstract_inverted_index.Results: | 102 |
| abstract_inverted_index.adjacent | 132 |
| abstract_inverted_index.affinity | 11 |
| abstract_inverted_index.cancers. | 27 |
| abstract_inverted_index.carrying | 98, 186, 205 |
| abstract_inverted_index.compared | 202 |
| abstract_inverted_index.detected | 48 |
| abstract_inverted_index.improved | 201 |
| abstract_inverted_index.indicate | 231 |
| abstract_inverted_index.resulted | 167 |
| abstract_inverted_index.survival | 90, 178 |
| abstract_inverted_index.tissues. | 134 |
| abstract_inverted_index.(SLC1A5), | 7 |
| abstract_inverted_index.Moreover, | 117 |
| abstract_inverted_index.apoptosis | 173 |
| abstract_inverted_index.blotting. | 53, 79 |
| abstract_inverted_index.cancerous | 122 |
| abstract_inverted_index.cytometry | 76 |
| abstract_inverted_index.decreased | 147 |
| abstract_inverted_index.essential | 17 |
| abstract_inverted_index.evaluated | 93 |
| abstract_inverted_index.expressed | 105 |
| abstract_inverted_index.glutamine | 19, 66, 155 |
| abstract_inverted_index.important | 236 |
| abstract_inverted_index.knockdown | 58, 85, 136, 166 |
| abstract_inverted_index.patients. | 116 |
| abstract_inverted_index.reported. | 39 |
| abstract_inverted_index.targeting | 254 |
| abstract_inverted_index.transport | 20 |
| abstract_inverted_index.esophageal | 34, 44, 69, 99, 114, 239, 250, 265 |
| abstract_inverted_index.expression | 42, 119 |
| abstract_inverted_index.inhibition | 159, 248 |
| abstract_inverted_index.metabolism | 24, 67 |
| abstract_inverted_index.signaling. | 162 |
| abstract_inverted_index.therefore, | 257 |
| abstract_inverted_index.transport, | 156 |
| abstract_inverted_index.viability, | 64 |
| abstract_inverted_index.Conclusion: | 228 |
| abstract_inverted_index.size/weight | 216 |
| abstract_inverted_index.transfected | 192, 211 |
| abstract_inverted_index.xenografts. | 101 |
| abstract_inverted_index.Furthermore, | 80 |
| abstract_inverted_index.consequences | 82 |
| abstract_inverted_index.investigated | 73 |
| abstract_inverted_index.preoperative | 262 |
| abstract_inverted_index.Additionally, | 163 |
| abstract_inverted_index.Solute-linked | 1 |
| abstract_inverted_index.significantly | 125, 146, 200, 219 |
| abstract_inverted_index.siRNA-mediated | 164 |
| abstract_inverted_index.Background/Aims: | 0 |
| abstract_inverted_index.immunohistochemistry | 50 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.79722675 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |