Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders Article Swipe
Carlos C. Flores
,
N Pasetto
,
Hongyang Wang
,
Alexander G. Dimitrov
,
Jon F. Davis
,
Zhihua Jiang
,
Christopher J. Davis
,
Jason R. Gerstner
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s44323-024-00012-2
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s44323-024-00012-2
Disruption of sleep and circadian rhythms are a comorbid feature of many pathologies, and can negatively influence many health conditions, including neurodegenerative disease, metabolic illness, cancer, and various neurological disorders. Genetic association studies linking sleep and circadian disturbances with disease susceptibility have mainly focused on changes in gene expression due to mutations, such as single-nucleotide polymorphisms. The interaction between sleep and/or circadian rhythms with the use of Alternative Polyadenylation (APA) has been largely undescribed, particularly in the context of other disorders. APA generates transcript isoforms by utilizing various polyadenylation sites (PASs) from the same gene affecting its mRNA translation, stability, localization, and subsequent function. Here we identified unique APAs expressed in rat brain over time-of-day, immediately following sleep deprivation, and the subsequent recovery period. From these data, we performed a secondary analysis of these sleep- or time-of-day associated PASs with recently described APA-linked human brain disorder susceptibility genes.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s44323-024-00012-2
- OA Status
- diamond
- Cited By
- 1
- References
- 89
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403982871Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s44323-024-00012-2Digital Object Identifier
- Title
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Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disordersWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-01Full publication date if available
- Authors
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Carlos C. Flores, N Pasetto, Hongyang Wang, Alexander G. Dimitrov, Jon F. Davis, Zhihua Jiang, Christopher J. Davis, Jason R. GerstnerList of authors in order
- Landing page
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https://doi.org/10.1038/s44323-024-00012-2Publisher landing page
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1038/s44323-024-00012-2Direct OA link when available
- Concepts
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Polyadenylation, Sleep (system call), Neuroscience, Psychology, Circadian rhythm, Medicine, Biology, Genetics, Computer science, Gene, Messenger RNA, Operating systemTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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