Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice Article Swipe
Shogo Tsuji
,
Cynthia S. Brace
,
Ruiqing Yao
,
Yoshitaka Tanie
,
Hirobumi Tada
,
Nicholas Rensing
,
Seiya Mizuno
,
Julio Almunia
,
Yingyi Kong
,
Kazuhiro Nakamura
,
Takahisa Furukawa
,
Noboru Ogiso
,
Shinya Toyokuni
,
Satoru Takahashi
,
Michael Wong
,
Shin‐ichiro Imai
,
Akiko Satoh
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202301992
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202301992
Old animals display significant alterations in sleep–wake patterns such as increases in sleep fragmentation and sleep propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons in the dorsomedial hypothalamus (DMH) are activated during sleep deprivation (SD) in young mice but not in old mice. Chemogenetic inhibition of Prdm13+ neurons in the DMH in young mice promotes increase in sleep attempts during SD, suggesting its involvement in sleep control. Furthermore, DMH-specific Prdm13 -knockout (DMH- Prdm13 -KO) mice recapitulated age-associated sleep alterations such as sleep fragmentation and increased sleep attempts during SD. These phenotypes were further exacerbated during aging, with increased adiposity and decreased physical activity, resulting in shortened lifespan. Dietary restriction (DR), a well-known anti-aging intervention in diverse organisms, ameliorated age-associated sleep fragmentation and increased sleep attempts during SD, whereas these effects of DR were abrogated in DMH- Prdm13 -KO mice. Moreover, overexpression of Prdm13 in the DMH ameliorated increased sleep attempts during SD in old mice. Therefore, maintaining Prdm13 signaling in the DMH might play an important role to control sleep–wake patterns during aging.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.26508/lsa.202301992
- https://www.life-science-alliance.org/content/lsa/6/6/e202301992.full.pdf
- OA Status
- gold
- Cited By
- 8
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4365142880
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4365142880Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.26508/lsa.202301992Digital Object Identifier
- Title
-
Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-12Full publication date if available
- Authors
-
Shogo Tsuji, Cynthia S. Brace, Ruiqing Yao, Yoshitaka Tanie, Hirobumi Tada, Nicholas Rensing, Seiya Mizuno, Julio Almunia, Yingyi Kong, Kazuhiro Nakamura, Takahisa Furukawa, Noboru Ogiso, Shinya Toyokuni, Satoru Takahashi, Michael Wong, Shin‐ichiro Imai, Akiko SatohList of authors in order
- Landing page
-
https://doi.org/10.26508/lsa.202301992Publisher landing page
- PDF URL
-
https://www.life-science-alliance.org/content/lsa/6/6/e202301992.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.life-science-alliance.org/content/lsa/6/6/e202301992.full.pdfDirect OA link when available
- Concepts
-
Sleep deprivation, Sleep restriction, Sleep (system call), Endocrinology, Internal medicine, Knockout mouse, Medicine, Psychology, Circadian rhythm, Receptor, Computer science, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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