SMIM20 promotes complex IV biogenesis and Ca2+ signaling in mice heart Article Swipe
Angela Boshnakovska
,
Julius Ryan D. Pronto
,
Tanja Gall
,
Abhishek Aich
,
Jan Procházka
,
Zuzana Nichtová
,
Radislav Sedláček
,
Izzatullo Sobitov
,
Sofia Ainatzi
,
Christof Lenz
,
Dörthe M. Katschinski
,
Henning Urlaub
,
Niels Voigt
,
Peter Rehling
,
Laura S. Kremer
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.115723
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.115723
Mitochondria are key to cellular energetics, metabolism, and signaling. Their dysfunction is linked to devastating diseases, including mitochondrial disorders, diabetes, neurodegenerative diseases, cardiac disorders, and cancer. Here, we present a knockout mouse model lacking the complex IV assembly factor SMIM20/MITRAC7. SMIM20-/- mice display cardiac pathology with reduced heart weight and cardiac output. Heart mitochondria present with reduced levels of complex IV associated with increased complex I activity, have altered fatty acid oxidation, and display elevated levels of ROS production. Interestingly, mutant mouse ventricular myocytes show unphysiological Ca2+ handling, which can be attributed to the increase in mitochondrial ROS production. Our study presents an example of a tissue-specific phenotype in the context of OXPHOS dysfunction. Moreover, our data suggest a link between complex IV dysfunction and Ca2+ handling at the endoplasmic reticulum through ROS signaling.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2025.115723
- OA Status
- gold
- References
- 82
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410514374
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410514374Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.celrep.2025.115723Digital Object Identifier
- Title
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SMIM20 promotes complex IV biogenesis and Ca2+ signaling in mice heartWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-20Full publication date if available
- Authors
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Angela Boshnakovska, Julius Ryan D. Pronto, Tanja Gall, Abhishek Aich, Jan Procházka, Zuzana Nichtová, Radislav Sedláček, Izzatullo Sobitov, Sofia Ainatzi, Christof Lenz, Dörthe M. Katschinski, Henning Urlaub, Niels Voigt, Peter Rehling, Laura S. KremerList of authors in order
- Landing page
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https://doi.org/10.1016/j.celrep.2025.115723Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.celrep.2025.115723Direct OA link when available
- Concepts
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Mitochondrial biogenesis, Mitochondrion, Endoplasmic reticulum, Context (archaeology), Cell biology, Biogenesis, Reactive oxygen species, Biology, Phenotype, Knockout mouse, Endocrinology, Oxidative phosphorylation, Internal medicine, Chemistry, Biochemistry, Medicine, Receptor, Gene, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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82Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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