Sodium alginate-guar gum and carbopol based methotrexate loaded mucoadhesive microparticles for colon delivery: An in vitro evaluation Article Swipe
Rohitas Deshmukh
,
Ranjit K. Harwansh
,
Mohammad Akhlaquer Rahman
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1590/s2175-97902020000419147
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1590/s2175-97902020000419147
Methotrexate (MTX) is famous for its therapeutic potential against different cancers including colorectal cancer. Goal of the present investigation was to formulate MTX loaded mucoadhesive microparticles for colon targeting. The optimized formulation (MTX-MS2) was composed of mucoadhesive polymers (sodium alginate, guar gum and carbopol 940) in an appropriate ratio. MTXMS2 was developed by ionic-gelation method. The suitable particle size and zeta potential were found to be 21.10 ± 0.18 μm and 3.01 ± 0.16 mV for MTX-MS2 respectively. The % yield (98.60 ± 2.12), % entrapment efficiency (97.98 ± 1.22) and % drug loading (1.04 ± 0.03) were estimated for MTXMS2. The swelling index (0.99 ± 0.04 θ) and mucoadhesion (97.29 ± 4.61%) were significantly (***P ˂ 0.01) achieved with MTX-MS2 as compared to other formulations. The optimum drug release (96.07 ± 4.52%) was significantly achieved with MTX-MS2 at simulated gastric fluid (pH 7.4) for 36 h in a sustained manner. This profile may be attributed towards excellent mucoadhesivness of the polymers used in the formulation. Therefore, the current investigation suggests that mucoadhesive carrier system could be promising approach for colon delivery. Thus, the proposed work would be helpful for the treatment of colorectal cancer.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1590/s2175-97902020000419147
- OA Status
- diamond
- Cited By
- 17
- References
- 26
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3217130430Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1590/s2175-97902020000419147Digital Object Identifier
- Title
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Sodium alginate-guar gum and carbopol based methotrexate loaded mucoadhesive microparticles for colon delivery: An in vitro evaluationWork title
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articleOpenAlex work type
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enPrimary language
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2021Year of publication
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2021-01-01Full publication date if available
- Authors
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Rohitas Deshmukh, Ranjit K. Harwansh, Mohammad Akhlaquer RahmanList of authors in order
- Landing page
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https://doi.org/10.1590/s2175-97902020000419147Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.1590/s2175-97902020000419147Direct OA link when available
- Concepts
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Guar gum, Mucoadhesion, Zeta potential, Swelling, Chemistry, Methotrexate, Drug delivery, Pharmacology, Sodium alginate, Materials science, Sodium, Drug carrier, Nanoparticle, Medicine, Nanotechnology, Surgery, Organic chemistry, Composite material, Food scienceTop concepts (fields/topics) attached by OpenAlex
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17Total citation count in OpenAlex
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2025: 3, 2024: 7, 2023: 4, 2022: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| primary_location.raw_source_name | Brazilian Journal of Pharmaceutical Sciences |
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| publication_date | 2021-01-01 |
| publication_year | 2021 |
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