Sodium-glucose cotransporter-2 (SGLT2) expression in diabetic and non-diabetic failing human cardiomyocytes Article Swipe
Raffaele Marfella
,
Lucia Scisciola
,
Nunzia D’Onofrio
,
Ciro Maiello
,
Maria Consiglia Trotta
,
Celestino Sardu
,
Iacopo Panarese
,
Franca Ferraraccio
,
Annalisa Capuano
,
Michelangela Barbieri
,
Maria Luisa Balestrieri
,
Claudio Napoli
,
Giuseppe Paolisso
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.phrs.2022.106448
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.phrs.2022.106448
This study aimed at investigating the SGLT2 expression in human cardiomyocytes. Human studies evaluating cardiomyocyte SGLT2s expression are limited. To better clarify this issue, SGLT2 protein expression was assessed in human hearts of diabetic and non-diabetic patients, and in AC16 human cardiomyocyte cell line. A prospective study with a follow-up of patients who underwent their first heart transplant (HTX) was performed. Explanted heart, basal (1 week after HTX), and final (48 weeks after HTX) endomyocardial biopsies (EMBs) from patients were evaluated for SGLT2 occurrence in cardiomyocyte with immunohistochemistry, immunofluorescence and SGLT2 quantization with both real-time reverse transcription-polymerase chain reaction and Western blot analysis. The immunofluorescence co-localization of SGLT2 in cardiomyocyte evidenced that an increased expression in the explanted heart from diabetic patients compared to non-diabetic (p < 0.001). In all final EMBs from diabetic patients, the expression of SGLT2 in cardiomyocyte was increased compared to non-diabetic (p < 0.01). This evidence was confirmed by Western blot analysis of SGLT2 protein. In addition, PCR analysis revealed very low mRNA levels in basal EMBs from diabetic and non-diabetic patients (p = NS), whereas final EMBs from diabetic patients showed higher SGLT2 mRNA levels in diabetic compared to non-diabetic patients (p < 0.05). Cultured human cardiomyocytes exposed to high-glucose showed increased expression of SGLT2 protein compared to cells exposed to normal glucose (p < 0.05). The presence of SGLT2 in cardiomyocytes supports the hypothesis of SGLT2i-mediated impact on metabolic pathways within cardiomyocytes. Moreover, metabolic disorders linked to diabetes may lead promptly to upregulation of SGLT2 levels in human cardiomyocytes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.phrs.2022.106448
- OA Status
- hybrid
- Cited By
- 122
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4295295994
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4295295994Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.phrs.2022.106448Digital Object Identifier
- Title
-
Sodium-glucose cotransporter-2 (SGLT2) expression in diabetic and non-diabetic failing human cardiomyocytesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-09Full publication date if available
- Authors
-
Raffaele Marfella, Lucia Scisciola, Nunzia D’Onofrio, Ciro Maiello, Maria Consiglia Trotta, Celestino Sardu, Iacopo Panarese, Franca Ferraraccio, Annalisa Capuano, Michelangela Barbieri, Maria Luisa Balestrieri, Claudio Napoli, Giuseppe PaolissoList of authors in order
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https://doi.org/10.1016/j.phrs.2022.106448Publisher landing page
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.phrs.2022.106448Direct OA link when available
- Concepts
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Diabetes mellitus, Medicine, Internal medicine, Western blot, Endocrinology, Basal (medicine), Immunofluorescence, Immunohistochemistry, Diabetic cardiomyopathy, Messenger RNA, Biology, Heart failure, Immunology, Antibody, Gene, Biochemistry, CardiomyopathyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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122Total citation count in OpenAlex
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2025: 33, 2024: 70, 2023: 12, 2022: 7Per-year citation counts (last 5 years)
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46Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.SGLT2 | 6, 24, 82, 90, 107, 138, 158, 188, 210, 225, 251 |
| abstract_inverted_index.after | 66, 72 |
| abstract_inverted_index.aimed | 2 |
| abstract_inverted_index.basal | 63, 170 |
| abstract_inverted_index.cells | 214 |
| abstract_inverted_index.chain | 97 |
| abstract_inverted_index.final | 69, 130, 181 |
| abstract_inverted_index.first | 55 |
| abstract_inverted_index.heart | 56, 118 |
| abstract_inverted_index.human | 9, 30, 40, 201, 254 |
| abstract_inverted_index.line. | 43 |
| abstract_inverted_index.study | 1, 46 |
| abstract_inverted_index.their | 54 |
| abstract_inverted_index.weeks | 71 |
| abstract_inverted_index.(EMBs) | 76 |
| abstract_inverted_index.0.01). | 148 |
| abstract_inverted_index.0.05). | 199, 221 |
| abstract_inverted_index.SGLT2s | 15 |
| abstract_inverted_index.better | 20 |
| abstract_inverted_index.heart, | 62 |
| abstract_inverted_index.hearts | 31 |
| abstract_inverted_index.higher | 187 |
| abstract_inverted_index.impact | 233 |
| abstract_inverted_index.issue, | 23 |
| abstract_inverted_index.levels | 168, 190, 252 |
| abstract_inverted_index.linked | 242 |
| abstract_inverted_index.normal | 217 |
| abstract_inverted_index.showed | 186, 206 |
| abstract_inverted_index.within | 237 |
| abstract_inverted_index.0.001). | 127 |
| abstract_inverted_index.Western | 100, 154 |
| abstract_inverted_index.clarify | 21 |
| abstract_inverted_index.exposed | 203, 215 |
| abstract_inverted_index.glucose | 218 |
| abstract_inverted_index.protein | 25, 211 |
| abstract_inverted_index.reverse | 95 |
| abstract_inverted_index.studies | 12 |
| abstract_inverted_index.whereas | 180 |
| abstract_inverted_index.Cultured | 200 |
| abstract_inverted_index.analysis | 156, 163 |
| abstract_inverted_index.assessed | 28 |
| abstract_inverted_index.biopsies | 75 |
| abstract_inverted_index.compared | 122, 143, 193, 212 |
| abstract_inverted_index.diabetes | 244 |
| abstract_inverted_index.diabetic | 33, 120, 133, 173, 184, 192 |
| abstract_inverted_index.evidence | 150 |
| abstract_inverted_index.limited. | 18 |
| abstract_inverted_index.pathways | 236 |
| abstract_inverted_index.patients | 51, 78, 121, 176, 185, 196 |
| abstract_inverted_index.presence | 223 |
| abstract_inverted_index.promptly | 247 |
| abstract_inverted_index.protein. | 159 |
| abstract_inverted_index.reaction | 98 |
| abstract_inverted_index.revealed | 164 |
| abstract_inverted_index.supports | 228 |
| abstract_inverted_index.Explanted | 61 |
| abstract_inverted_index.Moreover, | 239 |
| abstract_inverted_index.addition, | 161 |
| abstract_inverted_index.analysis. | 102 |
| abstract_inverted_index.confirmed | 152 |
| abstract_inverted_index.disorders | 241 |
| abstract_inverted_index.evaluated | 80 |
| abstract_inverted_index.evidenced | 110 |
| abstract_inverted_index.explanted | 117 |
| abstract_inverted_index.follow-up | 49 |
| abstract_inverted_index.increased | 113, 142, 207 |
| abstract_inverted_index.metabolic | 235, 240 |
| abstract_inverted_index.patients, | 36, 134 |
| abstract_inverted_index.real-time | 94 |
| abstract_inverted_index.underwent | 53 |
| abstract_inverted_index.evaluating | 13 |
| abstract_inverted_index.expression | 7, 16, 26, 114, 136, 208 |
| abstract_inverted_index.hypothesis | 230 |
| abstract_inverted_index.occurrence | 83 |
| abstract_inverted_index.performed. | 60 |
| abstract_inverted_index.transplant | 57 |
| abstract_inverted_index.prospective | 45 |
| abstract_inverted_index.high-glucose | 205 |
| abstract_inverted_index.non-diabetic | 35, 124, 145, 175, 195 |
| abstract_inverted_index.quantization | 91 |
| abstract_inverted_index.upregulation | 249 |
| abstract_inverted_index.cardiomyocyte | 14, 41, 85, 109, 140 |
| abstract_inverted_index.investigating | 4 |
| abstract_inverted_index.cardiomyocytes | 202, 227 |
| abstract_inverted_index.endomyocardial | 74 |
| abstract_inverted_index.SGLT2i-mediated | 232 |
| abstract_inverted_index.cardiomyocytes. | 10, 238, 255 |
| abstract_inverted_index.co-localization | 105 |
| abstract_inverted_index.immunofluorescence | 88, 104 |
| abstract_inverted_index.immunohistochemistry, | 87 |
| abstract_inverted_index.transcription-polymerase | 96 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5084616356 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I197809005, https://openalex.org/I4210121996 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9952166 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |