Soft Focused Shock Wave Treatment of Solid Tumors. Part I: Physico-mechanical Preconditions, Parametric Simulation and Technical Applicator Design Article Swipe
Axel Erich Theuer
,
Nicolas Schierbaum
,
Heike Niessner
,
Francisco Meraz-Torres
,
Tobias Sinnberg
,
Tilman E. Schäffer
,
Florian Läng
,
Thomas Eigentler
,
G. F. Walter
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6184724/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6184724/v1
Purpose To explore the feasibility of targeted impairment of malignant tumors by application of soft focused shock wave treatment, the physico-mechanical preconditions are investigated. This innovative “soft” approach is different from the FDA-approved high intensity focused ultrasound (HIFU)-based histotripsy. Methods Atomic force microscopy investigation for cell mechanics, multiple parametric simulations (DICOM/FEM analysis, MATLAB conversion to PZFLEX/ONSCALE). Results Individual tumor cell evaluation of physical properties as basis for multiple parametric simulations determine the optimal treatment parameters (total energy required, energy flux density, shock wave frequency) and applicator positions; design flexibility of applicator devices for extra- and intracorporeal treatment. Conclusion The fundamental feasibility and reliability of our approach were proven in tumor cells providing a reliable basis for the translation into clinical applications.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-6184724/v1
- https://www.researchsquare.com/article/rs-6184724/latest.pdf
- OA Status
- gold
- References
- 16
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408658402
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4408658402Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-6184724/v1Digital Object Identifier
- Title
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Soft Focused Shock Wave Treatment of Solid Tumors. Part I: Physico-mechanical Preconditions, Parametric Simulation and Technical Applicator DesignWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-20Full publication date if available
- Authors
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Axel Erich Theuer, Nicolas Schierbaum, Heike Niessner, Francisco Meraz-Torres, Tobias Sinnberg, Tilman E. Schäffer, Florian Läng, Thomas Eigentler, G. F. WalterList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-6184724/v1Publisher landing page
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https://www.researchsquare.com/article/rs-6184724/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.researchsquare.com/article/rs-6184724/latest.pdfDirect OA link when available
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Parametric design, Parametric statistics, Shock wave, Shock (circulatory), Computer science, Mechanical engineering, Engineering, Aerospace engineering, Medicine, Mathematics, Radiology, StatisticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2591822351, https://openalex.org/W3187668469, https://openalex.org/W2923673138, https://openalex.org/W1965858639, https://openalex.org/W2277944030, https://openalex.org/W140767752, https://openalex.org/W2265505631, https://openalex.org/W2027658823, https://openalex.org/W2069756116, https://openalex.org/W3049768544, https://openalex.org/W4200161936, https://openalex.org/W2604749772, https://openalex.org/W2408414067, https://openalex.org/W2092333222, https://openalex.org/W4384500276, https://openalex.org/W3148375137 |
| referenced_works_count | 16 |
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