Sol-gel TiO2-based coatings in 3D printed porous Ti-6Al-4V alloy structures as efficient antibacterial drug delivery systems: Thorough structural and biological characterization Article Swipe
Anna Knaislová
,
Diana Horkavcová
,
Eva Jablonská
,
Dalibor Vojtěch
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.apsadv.2025.100816
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.apsadv.2025.100816
The application of sol-gel coatings on titanium-based materials offers a promising approach for enhancing their bioactivity, antibacterial properties, and adhesion, particularly for biomedical applications. This study focuses, for the first time, on the preparation and characterization of sol-gel TiO2-based coatings containing hydroxyapatite and silver in 3D-printed porous gyroid and dodethick structures. TiO2-based coatings on the standard wrought Ti-Al-V alloy rods were used as a reference. The coatings were applied via the specific dip-coating process developed by the author team. The microstructural analysis revealed that the sol-gel coatings on the reference wrought rod samples were homogeneous and well-adhered. The coatings on the porous gyroid and dodethick structures exhibited some localized cracking due to the complex geometry of the porous structures. Bioactivity was evaluated through the standard in vitro simulated body fluid tests, confirming hydroxyapatite precipitation on HA-containing coatings. Antibacterial properties were assessed against Escherichia coli, demonstrating nearly 100 % bacterial inhibition for Ag-containing coatings. Cytotoxicity tests with L929 fibroblast cells indicated that coatings with lower Ag concentrations in sol were non-toxic, while higher Ag concentrations in sol resulted in reduced cell viability, particularly in gyroid structures.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.apsadv.2025.100816
- OA Status
- gold
- Cited By
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- References
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4413114467Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.apsadv.2025.100816Digital Object Identifier
- Title
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Sol-gel TiO2-based coatings in 3D printed porous Ti-6Al-4V alloy structures as efficient antibacterial drug delivery systems: Thorough structural and biological characterizationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
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2025-08-14Full publication date if available
- Authors
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Anna Knaislová, Diana Horkavcová, Eva Jablonská, Dalibor VojtěchList of authors in order
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https://doi.org/10.1016/j.apsadv.2025.100816Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.apsadv.2025.100816Direct OA link when available
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Characterization (materials science), Materials science, Drug delivery, Porosity, Alloy, Sol-gel, Nanotechnology, Titanium alloy, Metallurgy, Chemical engineering, Composite material, EngineeringTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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