Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents Article Swipe
Mohd Abul Kalam
,
Aws Alshamsan
,
Musaed Alkholief
,
Ibrahim A. Alsarra
,
Raisuddin Ali
,
Nazrul Haq
,
Md. Khalid Anwer
,
Faiyaz Shakeel
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.9b04004
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.9b04004
Glipizide (GLZ) is an oral hypoglycemic agent, which is a weakly aqueous soluble drug. The solubility values of GLZ in various neat solvents are scarce in the literature. Hence, the solubility of GLZ in 12 different neat solvents, namely, "water, methanol, ethanol, isopropanol (IPA), 1-butanol, 2-butanol, ethylene glycol (EG), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO), and Transcutol-HP (THP)", at "T = 298.2-318.2 K" and "p = 0.1 MPa" was measured. The recorded solubilities of GLZ were correlated by "van't Hoff and Apelblat models" using root-mean-square deviation (RMSD). The overall RMSD was obtained as 1.21 and 1.40% for "Apelblat and van't Hoff models", respectively. Different solubility parameters of all studied materials including drug and solvent were calculated to find the best solvent for GLZ. The solubilities of GLZ (expressed in mole fraction) have been found highest in DMSO (2.81 × 10-2), followed by THP, EA, 2-butanol, 1-butanol, IPA, PEG-400, ethanol, PG, methanol, EG, and water (1.98 × 10-4) at "T = 318.2 K". All investigated solubility parameters of GLZ were recorded very close to the DMSO. "Apparent thermodynamic analysis" showed an "endothermic and entropy-driven dissolution" of GLZ in the 12 different neat solvents. The highest molecular interactions were recorded in GLZ-DMSO compared to other combinations. Overall, DMSO has been considered as the best solvent for the solubilization of GLZ.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsomega.9b04004
- OA Status
- gold
- Cited By
- 53
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2999623818
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2999623818Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsomega.9b04004Digital Object Identifier
- Title
-
Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat SolventsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-10Full publication date if available
- Authors
-
Mohd Abul Kalam, Aws Alshamsan, Musaed Alkholief, Ibrahim A. Alsarra, Raisuddin Ali, Nazrul Haq, Md. Khalid Anwer, Faiyaz ShakeelList of authors in order
- Landing page
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https://doi.org/10.1021/acsomega.9b04004Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1021/acsomega.9b04004Direct OA link when available
- Concepts
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Solubility, Ethylene glycol, Solvent, Chemistry, Dissolution, Methanol, Glipizide, Dimethyl sulfoxide, Nuclear chemistry, Polyvinyl alcohol, Mole fraction, Ethyl acetate, Hildebrand solubility parameter, Chromatography, Organic chemistry, Physical chemistry, Medicine, Diabetes mellitus, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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53Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 12, 2023: 8, 2022: 14, 2021: 5Per-year citation counts (last 5 years)
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44Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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