Somapacitan-induced reversible lipoatrophy in an adult woman with hypopituitarism Article Swipe
Matej Rakuša
,
Andrej Janež
,
Mojca Jensterle
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s11102-024-01440-w
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s11102-024-01440-w
Background Lipoatrophy is rare adverse event (AE) in daily recombinant human growth hormone (rhGH). Data on lipoatrophy in newly developed long-acting GH (LAGH) are scarce. We report the first case of lipoatrophy in adult patient treated with LAGH somapacitan. Case presentation A 38-year-old woman with congenital panhypopituitarism was transitioned from daily rhGH 0.4 mg QD to somapacitan dose 4 mg QW due to non-adherence to daily rhGH. Despite adequate education and regular changing of injection sites, the patient reported reduced subcutaneous tissue at all four injection sites, after the 4th application of somapacitan. Somapacitan was discontinued at patient preference and lipoatrophy completely reversed after 3 months. Conclusions Lipoatrophy caused by somapacitan was completely reversible. We speculate that high initial dose and volume of somapacitan caused delayed diffusion and a direct local lipolytic effect in our patient. Although, titration of somapacitan was initiated as previously reported in REAL2 study protocol, recent clinical guidelines advise more gradual increase of somapacitan dose also in women on oral estogens that are switched from daily rhGH. Importantly, our case and the two previously described cases in children in the REAL 3 study showed that lipoatrophy caused by somapacitan was transient and completely reversible, and that discontinuation of the drug is not always mandatory.
Related Topics
Concepts
Lipoatrophy
Medicine
Discontinuation
Adverse effect
Hypopituitarism
Internal medicine
Pediatrics
Surgery
Endocrinology
Immunology
Human immunodeficiency virus (HIV)
Viral load
Antiretroviral therapy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s11102-024-01440-w
- OA Status
- hybrid
- Cited By
- 2
- References
- 3
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401465674
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401465674Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s11102-024-01440-wDigital Object Identifier
- Title
-
Somapacitan-induced reversible lipoatrophy in an adult woman with hypopituitarismWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-09Full publication date if available
- Authors
-
Matej Rakuša, Andrej Janež, Mojca JensterleList of authors in order
- Landing page
-
https://doi.org/10.1007/s11102-024-01440-wPublisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1007/s11102-024-01440-wDirect OA link when available
- Concepts
-
Lipoatrophy, Medicine, Discontinuation, Adverse effect, Hypopituitarism, Internal medicine, Pediatrics, Surgery, Endocrinology, Immunology, Human immunodeficiency virus (HIV), Viral load, Antiretroviral therapyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
3Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4401465674 |
|---|---|
| doi | https://doi.org/10.1007/s11102-024-01440-w |
| ids.doi | https://doi.org/10.1007/s11102-024-01440-w |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39120809 |
| ids.openalex | https://openalex.org/W4401465674 |
| fwci | 1.72590515 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D005260 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Female |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000328 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Adult |
| mesh[3].qualifier_ui | Q000188 |
| mesh[3].descriptor_ui | D007018 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug therapy |
| mesh[3].descriptor_name | Hypopituitarism |
| mesh[4].qualifier_ui | Q000009 |
| mesh[4].descriptor_ui | D019382 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | adverse effects |
| mesh[4].descriptor_name | Human Growth Hormone |
| mesh[5].qualifier_ui | Q000172 |
| mesh[5].descriptor_ui | D019382 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | deficiency |
| mesh[5].descriptor_name | Human Growth Hormone |
| mesh[6].qualifier_ui | Q000139 |
| mesh[6].descriptor_ui | D008060 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | chemically induced |
| mesh[6].descriptor_name | Lipodystrophy |
| mesh[7].qualifier_ui | Q000473 |
| mesh[7].descriptor_ui | D008060 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | pathology |
| mesh[7].descriptor_name | Lipodystrophy |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D005260 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Female |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000328 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Adult |
| mesh[11].qualifier_ui | Q000188 |
| mesh[11].descriptor_ui | D007018 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | drug therapy |
| mesh[11].descriptor_name | Hypopituitarism |
| mesh[12].qualifier_ui | Q000009 |
| mesh[12].descriptor_ui | D019382 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | adverse effects |
| mesh[12].descriptor_name | Human Growth Hormone |
| mesh[13].qualifier_ui | Q000172 |
| mesh[13].descriptor_ui | D019382 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | deficiency |
| mesh[13].descriptor_name | Human Growth Hormone |
| mesh[14].qualifier_ui | Q000139 |
| mesh[14].descriptor_ui | D008060 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | chemically induced |
| mesh[14].descriptor_name | Lipodystrophy |
| mesh[15].qualifier_ui | Q000473 |
| mesh[15].descriptor_ui | D008060 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pathology |
| mesh[15].descriptor_name | Lipodystrophy |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D005260 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Female |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000328 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Adult |
| mesh[19].qualifier_ui | Q000188 |
| mesh[19].descriptor_ui | D007018 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | drug therapy |
| mesh[19].descriptor_name | Hypopituitarism |
| mesh[20].qualifier_ui | Q000009 |
| mesh[20].descriptor_ui | D019382 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | adverse effects |
| mesh[20].descriptor_name | Human Growth Hormone |
| mesh[21].qualifier_ui | Q000172 |
| mesh[21].descriptor_ui | D019382 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | deficiency |
| mesh[21].descriptor_name | Human Growth Hormone |
| mesh[22].qualifier_ui | Q000139 |
| mesh[22].descriptor_ui | D008060 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | chemically induced |
| mesh[22].descriptor_name | Lipodystrophy |
| mesh[23].qualifier_ui | Q000473 |
| mesh[23].descriptor_ui | D008060 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | pathology |
| mesh[23].descriptor_name | Lipodystrophy |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D005260 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Female |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000328 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Adult |
| mesh[27].qualifier_ui | Q000188 |
| mesh[27].descriptor_ui | D007018 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | drug therapy |
| mesh[27].descriptor_name | Hypopituitarism |
| mesh[28].qualifier_ui | Q000009 |
| mesh[28].descriptor_ui | D019382 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | adverse effects |
| mesh[28].descriptor_name | Human Growth Hormone |
| mesh[29].qualifier_ui | Q000172 |
| mesh[29].descriptor_ui | D019382 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | deficiency |
| mesh[29].descriptor_name | Human Growth Hormone |
| mesh[30].qualifier_ui | Q000139 |
| mesh[30].descriptor_ui | D008060 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | chemically induced |
| mesh[30].descriptor_name | Lipodystrophy |
| mesh[31].qualifier_ui | Q000473 |
| mesh[31].descriptor_ui | D008060 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | pathology |
| mesh[31].descriptor_name | Lipodystrophy |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D006801 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Humans |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D005260 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Female |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D000328 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Adult |
| mesh[35].qualifier_ui | Q000188 |
| mesh[35].descriptor_ui | D007018 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | drug therapy |
| mesh[35].descriptor_name | Hypopituitarism |
| mesh[36].qualifier_ui | Q000009 |
| mesh[36].descriptor_ui | D019382 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | adverse effects |
| mesh[36].descriptor_name | Human Growth Hormone |
| mesh[37].qualifier_ui | Q000172 |
| mesh[37].descriptor_ui | D019382 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | deficiency |
| mesh[37].descriptor_name | Human Growth Hormone |
| mesh[38].qualifier_ui | Q000139 |
| mesh[38].descriptor_ui | D008060 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | chemically induced |
| mesh[38].descriptor_name | Lipodystrophy |
| mesh[39].qualifier_ui | Q000473 |
| mesh[39].descriptor_ui | D008060 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | pathology |
| mesh[39].descriptor_name | Lipodystrophy |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D006801 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Humans |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D005260 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Female |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D000328 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Adult |
| mesh[43].qualifier_ui | Q000188 |
| mesh[43].descriptor_ui | D007018 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | drug therapy |
| mesh[43].descriptor_name | Hypopituitarism |
| mesh[44].qualifier_ui | Q000009 |
| mesh[44].descriptor_ui | D019382 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | adverse effects |
| mesh[44].descriptor_name | Human Growth Hormone |
| mesh[45].qualifier_ui | Q000172 |
| mesh[45].descriptor_ui | D019382 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | deficiency |
| mesh[45].descriptor_name | Human Growth Hormone |
| mesh[46].qualifier_ui | Q000139 |
| mesh[46].descriptor_ui | D008060 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | chemically induced |
| mesh[46].descriptor_name | Lipodystrophy |
| mesh[47].qualifier_ui | Q000473 |
| mesh[47].descriptor_ui | D008060 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | pathology |
| mesh[47].descriptor_name | Lipodystrophy |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D006801 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Humans |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D005260 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Female |
| type | article |
| title | Somapacitan-induced reversible lipoatrophy in an adult woman with hypopituitarism |
| biblio.issue | 5 |
| biblio.volume | 27 |
| biblio.last_page | 739 |
| biblio.first_page | 737 |
| topics[0].id | https://openalex.org/T10748 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9976999759674072 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2712 |
| topics[0].subfield.display_name | Endocrinology, Diabetes and Metabolism |
| topics[0].display_name | Growth Hormone and Insulin-like Growth Factors |
| topics[1].id | https://openalex.org/T11171 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9916999936103821 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1311 |
| topics[1].subfield.display_name | Genetics |
| topics[1].display_name | Diabetes and associated disorders |
| topics[2].id | https://openalex.org/T11928 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9886000156402588 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1311 |
| topics[2].subfield.display_name | Genetics |
| topics[2].display_name | Genetic Syndromes and Imprinting |
| is_xpac | False |
| apc_list.value | 3290 |
| apc_list.currency | EUR |
| apc_list.value_usd | 3990 |
| apc_paid.value | 3290 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 3990 |
| concepts[0].id | https://openalex.org/C2779546735 |
| concepts[0].level | 5 |
| concepts[0].score | 0.9797747731208801 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q3500973 |
| concepts[0].display_name | Lipoatrophy |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.9088079929351807 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2778715236 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7687453627586365 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q55622662 |
| concepts[2].display_name | Discontinuation |
| concepts[3].id | https://openalex.org/C197934379 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6358963847160339 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2047938 |
| concepts[3].display_name | Adverse effect |
| concepts[4].id | https://openalex.org/C2778491484 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5018868446350098 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q922411 |
| concepts[4].display_name | Hypopituitarism |
| concepts[5].id | https://openalex.org/C126322002 |
| concepts[5].level | 1 |
| concepts[5].score | 0.41277840733528137 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[5].display_name | Internal medicine |
| concepts[6].id | https://openalex.org/C187212893 |
| concepts[6].level | 1 |
| concepts[6].score | 0.36988258361816406 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q123028 |
| concepts[6].display_name | Pediatrics |
| concepts[7].id | https://openalex.org/C141071460 |
| concepts[7].level | 1 |
| concepts[7].score | 0.34334689378738403 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[7].display_name | Surgery |
| concepts[8].id | https://openalex.org/C134018914 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3382297456264496 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[8].display_name | Endocrinology |
| concepts[9].id | https://openalex.org/C203014093 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0763024389743805 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[9].display_name | Immunology |
| concepts[10].id | https://openalex.org/C3013748606 |
| concepts[10].level | 2 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q15787 |
| concepts[10].display_name | Human immunodeficiency virus (HIV) |
| concepts[11].id | https://openalex.org/C142462285 |
| concepts[11].level | 3 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q2528140 |
| concepts[11].display_name | Viral load |
| concepts[12].id | https://openalex.org/C2993143319 |
| concepts[12].level | 4 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q583050 |
| concepts[12].display_name | Antiretroviral therapy |
| keywords[0].id | https://openalex.org/keywords/lipoatrophy |
| keywords[0].score | 0.9797747731208801 |
| keywords[0].display_name | Lipoatrophy |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.9088079929351807 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/discontinuation |
| keywords[2].score | 0.7687453627586365 |
| keywords[2].display_name | Discontinuation |
| keywords[3].id | https://openalex.org/keywords/adverse-effect |
| keywords[3].score | 0.6358963847160339 |
| keywords[3].display_name | Adverse effect |
| keywords[4].id | https://openalex.org/keywords/hypopituitarism |
| keywords[4].score | 0.5018868446350098 |
| keywords[4].display_name | Hypopituitarism |
| keywords[5].id | https://openalex.org/keywords/internal-medicine |
| keywords[5].score | 0.41277840733528137 |
| keywords[5].display_name | Internal medicine |
| keywords[6].id | https://openalex.org/keywords/pediatrics |
| keywords[6].score | 0.36988258361816406 |
| keywords[6].display_name | Pediatrics |
| keywords[7].id | https://openalex.org/keywords/surgery |
| keywords[7].score | 0.34334689378738403 |
| keywords[7].display_name | Surgery |
| keywords[8].id | https://openalex.org/keywords/endocrinology |
| keywords[8].score | 0.3382297456264496 |
| keywords[8].display_name | Endocrinology |
| keywords[9].id | https://openalex.org/keywords/immunology |
| keywords[9].score | 0.0763024389743805 |
| keywords[9].display_name | Immunology |
| language | en |
| locations[0].id | doi:10.1007/s11102-024-01440-w |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S142774597 |
| locations[0].source.issn | 1386-341X, 1573-7403 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1386-341X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Pituitary |
| locations[0].source.host_organization | https://openalex.org/P4310319900 |
| locations[0].source.host_organization_name | Springer Science+Business Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319900 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Pituitary |
| locations[0].landing_page_url | https://doi.org/10.1007/s11102-024-01440-w |
| locations[1].id | pmid:39120809 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Pituitary |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39120809 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11513695 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Pituitary |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11513695 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5056109424 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8044-3527 |
| authorships[0].author.display_name | Matej Rakuša |
| authorships[0].countries | SI |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I153976015, https://openalex.org/I2801323708 |
| authorships[0].affiliations[0].raw_affiliation_string | Faculty of Medicine, University Medical Centre Ljubljana, University of Ljubljana, Zaloška cesta 7, Ljubljana, SI-1000, Slovenia |
| authorships[0].institutions[0].id | https://openalex.org/I2801323708 |
| authorships[0].institutions[0].ror | https://ror.org/01nr6fy72 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2801323708 |
| authorships[0].institutions[0].country_code | SI |
| authorships[0].institutions[0].display_name | Ljubljana University Medical Centre |
| authorships[0].institutions[1].id | https://openalex.org/I153976015 |
| authorships[0].institutions[1].ror | https://ror.org/05njb9z20 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I153976015 |
| authorships[0].institutions[1].country_code | SI |
| authorships[0].institutions[1].display_name | University of Ljubljana |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Matej Rakusa |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Faculty of Medicine, University Medical Centre Ljubljana, University of Ljubljana, Zaloška cesta 7, Ljubljana, SI-1000, Slovenia |
| authorships[1].author.id | https://openalex.org/A5002770606 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6594-5254 |
| authorships[1].author.display_name | Andrej Janež |
| authorships[1].countries | SI |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I153976015, https://openalex.org/I2801323708 |
| authorships[1].affiliations[0].raw_affiliation_string | Faculty of Medicine, University Medical Centre Ljubljana, University of Ljubljana, Zaloška cesta 7, Ljubljana, SI-1000, Slovenia |
| authorships[1].institutions[0].id | https://openalex.org/I2801323708 |
| authorships[1].institutions[0].ror | https://ror.org/01nr6fy72 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2801323708 |
| authorships[1].institutions[0].country_code | SI |
| authorships[1].institutions[0].display_name | Ljubljana University Medical Centre |
| authorships[1].institutions[1].id | https://openalex.org/I153976015 |
| authorships[1].institutions[1].ror | https://ror.org/05njb9z20 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I153976015 |
| authorships[1].institutions[1].country_code | SI |
| authorships[1].institutions[1].display_name | University of Ljubljana |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Andrej Janez |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Faculty of Medicine, University Medical Centre Ljubljana, University of Ljubljana, Zaloška cesta 7, Ljubljana, SI-1000, Slovenia |
| authorships[2].author.id | https://openalex.org/A5091436678 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8861-8803 |
| authorships[2].author.display_name | Mojca Jensterle |
| authorships[2].countries | SI |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I153976015, https://openalex.org/I2801323708 |
| authorships[2].affiliations[0].raw_affiliation_string | Faculty of Medicine, University Medical Centre Ljubljana, University of Ljubljana, Zaloška cesta 7, Ljubljana, SI-1000, Slovenia |
| authorships[2].institutions[0].id | https://openalex.org/I2801323708 |
| authorships[2].institutions[0].ror | https://ror.org/01nr6fy72 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2801323708 |
| authorships[2].institutions[0].country_code | SI |
| authorships[2].institutions[0].display_name | Ljubljana University Medical Centre |
| authorships[2].institutions[1].id | https://openalex.org/I153976015 |
| authorships[2].institutions[1].ror | https://ror.org/05njb9z20 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I153976015 |
| authorships[2].institutions[1].country_code | SI |
| authorships[2].institutions[1].display_name | University of Ljubljana |
| authorships[2].author_position | last |
| authorships[2].raw_author_name | Mojca Jensterle |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Faculty of Medicine, University Medical Centre Ljubljana, University of Ljubljana, Zaloška cesta 7, Ljubljana, SI-1000, Slovenia |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1007/s11102-024-01440-w |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Somapacitan-induced reversible lipoatrophy in an adult woman with hypopituitarism |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10748 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9976999759674072 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2712 |
| primary_topic.subfield.display_name | Endocrinology, Diabetes and Metabolism |
| primary_topic.display_name | Growth Hormone and Insulin-like Growth Factors |
| related_works | https://openalex.org/W2360693916, https://openalex.org/W2103301585, https://openalex.org/W2081914733, https://openalex.org/W2464739384, https://openalex.org/W2415484199, https://openalex.org/W1999070253, https://openalex.org/W4386640344, https://openalex.org/W2318402467, https://openalex.org/W3200099207, https://openalex.org/W2990195765 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1007/s11102-024-01440-w |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S142774597 |
| best_oa_location.source.issn | 1386-341X, 1573-7403 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1386-341X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Pituitary |
| best_oa_location.source.host_organization | https://openalex.org/P4310319900 |
| best_oa_location.source.host_organization_name | Springer Science+Business Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Pituitary |
| best_oa_location.landing_page_url | https://doi.org/10.1007/s11102-024-01440-w |
| primary_location.id | doi:10.1007/s11102-024-01440-w |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S142774597 |
| primary_location.source.issn | 1386-341X, 1573-7403 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1386-341X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Pituitary |
| primary_location.source.host_organization | https://openalex.org/P4310319900 |
| primary_location.source.host_organization_name | Springer Science+Business Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Pituitary |
| primary_location.landing_page_url | https://doi.org/10.1007/s11102-024-01440-w |
| publication_date | 2024-08-09 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2792828483, https://openalex.org/W4361263429, https://openalex.org/W4312173183 |
| referenced_works_count | 3 |
| abstract_inverted_index.3 | 105, 186 |
| abstract_inverted_index.4 | 59 |
| abstract_inverted_index.A | 42 |
| abstract_inverted_index.a | 129 |
| abstract_inverted_index.GH | 22 |
| abstract_inverted_index.QD | 55 |
| abstract_inverted_index.QW | 61 |
| abstract_inverted_index.We | 26, 115 |
| abstract_inverted_index.as | 143 |
| abstract_inverted_index.at | 83, 97 |
| abstract_inverted_index.by | 110, 192 |
| abstract_inverted_index.in | 8, 18, 33, 134, 146, 161, 181, 183 |
| abstract_inverted_index.is | 3, 205 |
| abstract_inverted_index.mg | 54, 60 |
| abstract_inverted_index.of | 31, 74, 92, 123, 139, 157, 202 |
| abstract_inverted_index.on | 16, 163 |
| abstract_inverted_index.to | 56, 63, 65 |
| abstract_inverted_index.0.4 | 53 |
| abstract_inverted_index.4th | 90 |
| abstract_inverted_index.all | 84 |
| abstract_inverted_index.and | 71, 100, 121, 128, 175, 196, 199 |
| abstract_inverted_index.are | 24, 167 |
| abstract_inverted_index.due | 62 |
| abstract_inverted_index.not | 206 |
| abstract_inverted_index.our | 135, 173 |
| abstract_inverted_index.the | 28, 77, 89, 176, 184, 203 |
| abstract_inverted_index.two | 177 |
| abstract_inverted_index.was | 48, 95, 112, 141, 194 |
| abstract_inverted_index.(AE) | 7 |
| abstract_inverted_index.Case | 40 |
| abstract_inverted_index.Data | 15 |
| abstract_inverted_index.LAGH | 38 |
| abstract_inverted_index.REAL | 185 |
| abstract_inverted_index.also | 160 |
| abstract_inverted_index.case | 30, 174 |
| abstract_inverted_index.dose | 58, 120, 159 |
| abstract_inverted_index.drug | 204 |
| abstract_inverted_index.four | 85 |
| abstract_inverted_index.from | 50, 169 |
| abstract_inverted_index.high | 118 |
| abstract_inverted_index.more | 154 |
| abstract_inverted_index.oral | 164 |
| abstract_inverted_index.rare | 4 |
| abstract_inverted_index.rhGH | 52 |
| abstract_inverted_index.that | 117, 166, 189, 200 |
| abstract_inverted_index.with | 37, 45 |
| abstract_inverted_index.REAL2 | 147 |
| abstract_inverted_index.adult | 34 |
| abstract_inverted_index.after | 88, 104 |
| abstract_inverted_index.cases | 180 |
| abstract_inverted_index.daily | 9, 51, 66, 170 |
| abstract_inverted_index.event | 6 |
| abstract_inverted_index.first | 29 |
| abstract_inverted_index.human | 11 |
| abstract_inverted_index.local | 131 |
| abstract_inverted_index.newly | 19 |
| abstract_inverted_index.rhGH. | 67, 171 |
| abstract_inverted_index.study | 148, 187 |
| abstract_inverted_index.woman | 44 |
| abstract_inverted_index.women | 162 |
| abstract_inverted_index.(LAGH) | 23 |
| abstract_inverted_index.advise | 153 |
| abstract_inverted_index.always | 207 |
| abstract_inverted_index.caused | 109, 125, 191 |
| abstract_inverted_index.direct | 130 |
| abstract_inverted_index.effect | 133 |
| abstract_inverted_index.growth | 12 |
| abstract_inverted_index.recent | 150 |
| abstract_inverted_index.report | 27 |
| abstract_inverted_index.showed | 188 |
| abstract_inverted_index.sites, | 76, 87 |
| abstract_inverted_index.tissue | 82 |
| abstract_inverted_index.volume | 122 |
| abstract_inverted_index.(rhGH). | 14 |
| abstract_inverted_index.Despite | 68 |
| abstract_inverted_index.adverse | 5 |
| abstract_inverted_index.delayed | 126 |
| abstract_inverted_index.gradual | 155 |
| abstract_inverted_index.hormone | 13 |
| abstract_inverted_index.initial | 119 |
| abstract_inverted_index.months. | 106 |
| abstract_inverted_index.patient | 35, 78, 98 |
| abstract_inverted_index.reduced | 80 |
| abstract_inverted_index.regular | 72 |
| abstract_inverted_index.scarce. | 25 |
| abstract_inverted_index.treated | 36 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.adequate | 69 |
| abstract_inverted_index.changing | 73 |
| abstract_inverted_index.children | 182 |
| abstract_inverted_index.clinical | 151 |
| abstract_inverted_index.estogens | 165 |
| abstract_inverted_index.increase | 156 |
| abstract_inverted_index.patient. | 136 |
| abstract_inverted_index.reported | 79, 145 |
| abstract_inverted_index.reversed | 103 |
| abstract_inverted_index.switched | 168 |
| abstract_inverted_index.Although, | 137 |
| abstract_inverted_index.described | 179 |
| abstract_inverted_index.developed | 20 |
| abstract_inverted_index.diffusion | 127 |
| abstract_inverted_index.education | 70 |
| abstract_inverted_index.initiated | 142 |
| abstract_inverted_index.injection | 75, 86 |
| abstract_inverted_index.lipolytic | 132 |
| abstract_inverted_index.protocol, | 149 |
| abstract_inverted_index.speculate | 116 |
| abstract_inverted_index.titration | 138 |
| abstract_inverted_index.transient | 195 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.completely | 102, 113, 197 |
| abstract_inverted_index.congenital | 46 |
| abstract_inverted_index.guidelines | 152 |
| abstract_inverted_index.mandatory. | 208 |
| abstract_inverted_index.preference | 99 |
| abstract_inverted_index.previously | 144, 178 |
| abstract_inverted_index.38-year-old | 43 |
| abstract_inverted_index.Conclusions | 107 |
| abstract_inverted_index.Lipoatrophy | 2, 108 |
| abstract_inverted_index.Somapacitan | 94 |
| abstract_inverted_index.application | 91 |
| abstract_inverted_index.lipoatrophy | 17, 32, 101, 190 |
| abstract_inverted_index.long-acting | 21 |
| abstract_inverted_index.recombinant | 10 |
| abstract_inverted_index.reversible, | 198 |
| abstract_inverted_index.reversible. | 114 |
| abstract_inverted_index.somapacitan | 57, 111, 124, 140, 158, 193 |
| abstract_inverted_index.Importantly, | 172 |
| abstract_inverted_index.discontinued | 96 |
| abstract_inverted_index.presentation | 41 |
| abstract_inverted_index.somapacitan. | 39, 93 |
| abstract_inverted_index.subcutaneous | 81 |
| abstract_inverted_index.transitioned | 49 |
| abstract_inverted_index.non-adherence | 64 |
| abstract_inverted_index.discontinuation | 201 |
| abstract_inverted_index.panhypopituitarism | 47 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4099999964237213 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.78348708 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |