Spasmolytic Effect of Grewia asiatica Fruit Extract on Isolated Smooth Muscles is Mediated via Multiple Pathways Article Swipe
Muhammad Nabeel Ghayur
,
Saeed Ahmad
,
Anwarul Hassan Gilani
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1155/2021/5583372
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1155/2021/5583372
Background. Grewia asiatica Linn, or phalsa, is a commonly consumed fruit in Pakistan. The fruit is employed in the traditional medicine practice of Pakistan as a smooth muscle relaxant in different gastrointestinal (GI) and cardiovascular diseases. In this investigation, we show the antispasmodic and vasorelaxant actions of Grewia asiatica fruit extract. Methods. A 70% methanolic crude extract of the plant material was prepared (Ga.Cr). Different isolated GI tissue preparations and endothelium-intact aortas from rats were utilized to observe the pharmacological actions of the extract. Results. Ga.Cr, in increasing concentrations, inhibited the spontaneously contracting rabbit jejunum. In an effort to determine the mechanism of this relaxant action, contractions were induced in jejunum and ileum tissues with K+ (80 mM). Ga.Cr was able to only partially inhibit these induced contractions indicating that the mechanism might not be completely through a blockade of Ca2+ channels (CCB). When tested on low K+-(25 mM) sustained contractions, Ga.Cr cumulatively suppressed these contractions (0.1–10 mg/ml), indicating an opening of K+ channels (KCO) as the mechanism. Cromakalim, a standard KCO, was also more specific in blocking low K+-induced contractions. For the effect in aorta tissues, Ga.Cr suppressed the agonist-induced contractions from 0.3 mg/ml to 10 mg/ml. Upon challenge with L-NAME, a nitric oxide (NO) blocker, the extract response curve shifted right, indicating vasodilation was mediated via endothelial NO. Conclusion. This study shows that GI antispasmodic and vasodilator activities of Ga.Cr may be mediated via a KCO mechanism in the GI tract and through the release of NO from vascular endothelium.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2021/5583372
- https://downloads.hindawi.com/journals/ecam/2021/5583372.pdf
- OA Status
- hybrid
- Cited By
- 4
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3199686156
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3199686156Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1155/2021/5583372Digital Object Identifier
- Title
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Spasmolytic Effect of Grewia asiatica Fruit Extract on Isolated Smooth Muscles is Mediated via Multiple PathwaysWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-09-13Full publication date if available
- Authors
-
Muhammad Nabeel Ghayur, Saeed Ahmad, Anwarul Hassan GilaniList of authors in order
- Landing page
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https://doi.org/10.1155/2021/5583372Publisher landing page
- PDF URL
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https://downloads.hindawi.com/journals/ecam/2021/5583372.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://downloads.hindawi.com/journals/ecam/2021/5583372.pdfDirect OA link when available
- Concepts
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Antispasmodic, Vasodilation, Pharmacology, Jejunum, Chemistry, Ileum, Mechanism of action, Nitric oxide, Contraction (grammar), Traditional medicine, Agonist, Medicine, Endocrinology, Receptor, Biochemistry, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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