Spatial and Temporal Control of Immune Cell Activation Article Swipe
The innate control of adaptive immunity has been the target of various therapeutics. By the chemical modification of the chemical patterns recognized by the Toll-like receptors (TLRs) on innate immune cells, we can further control the systemic immune response. Chemical modifications can be used to control the spatial presentation of multiple TLR agonists by covalent conjugation of two TLR agonists which serve as a synthetic mimic of macromolecular pathogens. Additionally, photocaging of TLR agonists is used to control the spatial and temporal presentation of agonists. These strategies would further provide mechanistic insight in TLR synergy as well as therapeutic insight in modulating the immune response.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://escholarship.org/uc/item/7b02k142
- https://escholarship.org/uc/item/7b02k142
- OA Status
- green
- Related Works
- 20
- OpenAlex ID
- https://openalex.org/W2768001175
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2768001175Canonical identifier for this work in OpenAlex
- Title
-
Spatial and Temporal Control of Immune Cell ActivationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-01-01Full publication date if available
- Authors
-
Keun Ah RyuList of authors in order
- Landing page
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https://escholarship.org/uc/item/7b02k142Publisher landing page
- PDF URL
-
https://escholarship.org/uc/item/7b02k142Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://escholarship.org/uc/item/7b02k142Direct OA link when available
- Concepts
-
Immune system, Innate immune system, Acquired immune system, Biology, Receptor, Immunity, Immunology, Neuroscience, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
20Other works algorithmically related by OpenAlex
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