Temporal variability in emissions from oil and gas supply chains depends on the spatial scale at which emissions are aggregated. This work demonstrates a framework for simulating temporally and spatially resolved emission inventories that can be broadly applied in oil and gas production regions. Emissions of methane, ethane, volatile organic compounds (VOCs), and nitrogen oxides (NOxs) from oil and gas facilities in the Marcellus production region were estimated at a one-hour time resolution for the calendar year …