Spatial Transcriptomics Reveals Distinct Architectures but Shared Vulnerabilities in Primary and Metastatic Liver Tumors Article Swipe
Swamy R. Adapa
,
Sahanama Porshe
,
Divya Priyanka Talada
,
Timothy M. Nywening
,
Margaret Lavinia Anderson
,
Timothy I. Shaw
,
Rays H. Y. Jiang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17193210
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17193210
Background: Primary hepatocellular carcinoma (HCC) and liver metastases differ in origin, progression, and therapeutic response, yet a direct high-resolution spatial comparison of their tumor microenvironments (TMEs) within the liver has not previously been performed. Methods: We applied high-definition spatial transcriptomics to fresh-frozen specimens of one HCC and one liver metastasis (>16,000 genes per sample, >97% mapping rates) as a proof-of-principle two-specimen study, cross-validated in human proteomics and patients’ survival datasets. Transcriptional clustering revealed spatially distinct compartments, rare cell states, and pathway alterations, which were further compared against an independent systemic dataset. Results: HCC displayed an ordered lineage architecture, with transformed hepatocyte-like tumor cells broadly dispersed across the tissue and more differentiated hepatocyte-derived cells restricted to localized zones. By contrast, liver metastases showed two sharply compartmentalized domains: an invasion zone, where proliferative stem-like tumor cells occupied TAM-rich boundaries adjacent to hypoxia-adapted tumor-core cells, and a plasticity zone, which formed a heterogeneous niche of cancer–testis antigen–positive germline-like cells. Across both tumor types, we detected a conserved metabolic program of “porphyrin overdrive,” defined by reduced cytochrome P450 expression, enhanced oxidative phosphorylation gene expression, and upregulation of FLVCR1 and ALOX5, reflecting coordinated rewiring of heme and lipid metabolism. Conclusions: In this pilot study, HCC and liver metastases demonstrated fundamentally different spatial architectures, with metastases uniquely harboring a germline/neural-like plasticity hub. Despite these organizational contrasts, both tumor types converged on a shared program of metabolic rewiring, highlighting potential therapeutic targets that link local tumor niches to systemic host–tumor interactions.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers17193210
- https://www.mdpi.com/2072-6694/17/19/3210/pdf?version=1759317161
- OA Status
- gold
- References
- 79
- OpenAlex ID
- https://openalex.org/W4414737416
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4414737416Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers17193210Digital Object Identifier
- Title
-
Spatial Transcriptomics Reveals Distinct Architectures but Shared Vulnerabilities in Primary and Metastatic Liver TumorsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-10-01Full publication date if available
- Authors
-
Swamy R. Adapa, Sahanama Porshe, Divya Priyanka Talada, Timothy M. Nywening, Margaret Lavinia Anderson, Timothy I. Shaw, Rays H. Y. JiangList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers17193210Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/17/19/3210/pdf?version=1759317161Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/17/19/3210/pdf?version=1759317161Direct OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
79Number of works referenced by this work
Full payload
| id | https://openalex.org/W4414737416 |
|---|---|
| doi | https://doi.org/10.3390/cancers17193210 |
| ids.doi | https://doi.org/10.3390/cancers17193210 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41097737 |
| ids.openalex | https://openalex.org/W4414737416 |
| fwci | 0.0 |
| type | article |
| title | Spatial Transcriptomics Reveals Distinct Architectures but Shared Vulnerabilities in Primary and Metastatic Liver Tumors |
| biblio.issue | 19 |
| biblio.volume | 17 |
| biblio.last_page | 3210 |
| biblio.first_page | 3210 |
| topics[0].id | https://openalex.org/T11287 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9994999766349792 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1306 |
| topics[0].subfield.display_name | Cancer Research |
| topics[0].display_name | Cancer Genomics and Diagnostics |
| topics[1].id | https://openalex.org/T11297 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9991999864578247 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Ferroptosis and cancer prognosis |
| topics[2].id | https://openalex.org/T11289 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9976999759674072 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Single-cell and spatial transcriptomics |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| language | en |
| locations[0].id | doi:10.3390/cancers17193210 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S168415115 |
| locations[0].source.issn | 2072-6694 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2072-6694 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancers |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2072-6694/17/19/3210/pdf?version=1759317161 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancers |
| locations[0].landing_page_url | https://doi.org/10.3390/cancers17193210 |
| locations[1].id | pmid:41097737 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancers |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41097737 |
| locations[2].id | pmh:oai:europepmc.org:11335447 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12523610 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5034330439 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-3313-2782 |
| authorships[0].author.display_name | Swamy R. Adapa |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2613432, https://openalex.org/I4210161586 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Global, Environmental, and Genomic Health Sciences, College of Public Health, University of South Florida, Tampa, FL 33612, USA |
| authorships[0].institutions[0].id | https://openalex.org/I4210161586 |
| authorships[0].institutions[0].ror | https://ror.org/05njgh475 |
| authorships[0].institutions[0].type | company |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210161586 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Genomic Health (United States) |
| authorships[0].institutions[1].id | https://openalex.org/I2613432 |
| authorships[0].institutions[1].ror | https://ror.org/032db5x82 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I2613432 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of South Florida |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Swamy R. Adapa |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Global, Environmental, and Genomic Health Sciences, College of Public Health, University of South Florida, Tampa, FL 33612, USA |
| authorships[1].author.id | https://openalex.org/A5119807577 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Sahanama Porshe |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2613432 |
| authorships[1].affiliations[0].raw_affiliation_string | Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA |
| authorships[1].institutions[0].id | https://openalex.org/I2613432 |
| authorships[1].institutions[0].ror | https://ror.org/032db5x82 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I2613432 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of South Florida |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Sahanama Porshe |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA |
| authorships[2].author.id | https://openalex.org/A5119227371 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Divya Priyanka Talada |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2613432 |
| authorships[2].affiliations[0].raw_affiliation_string | Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I3019308854 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA |
| authorships[2].institutions[0].id | https://openalex.org/I3019308854 |
| authorships[2].institutions[0].ror | https://ror.org/01xf75524 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I3019308854 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Moffitt Cancer Center |
| authorships[2].institutions[1].id | https://openalex.org/I2613432 |
| authorships[2].institutions[1].ror | https://ror.org/032db5x82 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I2613432 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | University of South Florida |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Divya Priyanka Talada |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA |
| authorships[3].author.id | https://openalex.org/A5084371532 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Timothy M. Nywening |
| authorships[3].countries | FR, US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2613432, https://openalex.org/I4210118524 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Surgery, University of South Florida, 560 Channelside, Drive, Tampa, FL 33602, USA |
| authorships[3].institutions[0].id | https://openalex.org/I4210118524 |
| authorships[3].institutions[0].ror | https://ror.org/02dn7x778 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210118524 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Université Bourgogne Franche-Comté |
| authorships[3].institutions[1].id | https://openalex.org/I2613432 |
| authorships[3].institutions[1].ror | https://ror.org/032db5x82 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I2613432 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | University of South Florida |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Timothy M. Nywening |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Surgery, University of South Florida, 560 Channelside, Drive, Tampa, FL 33602, USA |
| authorships[4].author.id | https://openalex.org/A5039971470 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1245-2445 |
| authorships[4].author.display_name | Margaret Lavinia Anderson |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2613432 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33606, USA |
| authorships[4].institutions[0].id | https://openalex.org/I2613432 |
| authorships[4].institutions[0].ror | https://ror.org/032db5x82 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I2613432 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of South Florida |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mattew L. Anderson |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33606, USA |
| authorships[5].author.id | https://openalex.org/A5029857449 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-9316-1924 |
| authorships[5].author.display_name | Timothy I. Shaw |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I3019308854 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA |
| authorships[5].institutions[0].id | https://openalex.org/I3019308854 |
| authorships[5].institutions[0].ror | https://ror.org/01xf75524 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I3019308854 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Moffitt Cancer Center |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Timothy I. Shaw |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA |
| authorships[6].author.id | https://openalex.org/A5075555324 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-8982-4169 |
| authorships[6].author.display_name | Rays H. Y. Jiang |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I2613432, https://openalex.org/I4210161586 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Global, Environmental, and Genomic Health Sciences, College of Public Health, University of South Florida, Tampa, FL 33612, USA |
| authorships[6].institutions[0].id | https://openalex.org/I4210161586 |
| authorships[6].institutions[0].ror | https://ror.org/05njgh475 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210161586 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Genomic Health (United States) |
| authorships[6].institutions[1].id | https://openalex.org/I2613432 |
| authorships[6].institutions[1].ror | https://ror.org/032db5x82 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I2613432 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | University of South Florida |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Rays H. Y. Jiang |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Global, Environmental, and Genomic Health Sciences, College of Public Health, University of South Florida, Tampa, FL 33612, USA |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2072-6694/17/19/3210/pdf?version=1759317161 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Spatial Transcriptomics Reveals Distinct Architectures but Shared Vulnerabilities in Primary and Metastatic Liver Tumors |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11287 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9994999766349792 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1306 |
| primary_topic.subfield.display_name | Cancer Research |
| primary_topic.display_name | Cancer Genomics and Diagnostics |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3390/cancers17193210 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S168415115 |
| best_oa_location.source.issn | 2072-6694 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2072-6694 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancers |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2072-6694/17/19/3210/pdf?version=1759317161 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancers |
| best_oa_location.landing_page_url | https://doi.org/10.3390/cancers17193210 |
| primary_location.id | doi:10.3390/cancers17193210 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S168415115 |
| primary_location.source.issn | 2072-6694 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2072-6694 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancers |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2072-6694/17/19/3210/pdf?version=1759317161 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancers |
| primary_location.landing_page_url | https://doi.org/10.3390/cancers17193210 |
| publication_date | 2025-10-01 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3178723556, https://openalex.org/W4290072634, https://openalex.org/W4381249426, https://openalex.org/W4200300652, https://openalex.org/W2339442385, https://openalex.org/W4404611844, https://openalex.org/W4323924126, https://openalex.org/W4385555989, https://openalex.org/W4391649973, https://openalex.org/W3015450697, https://openalex.org/W1497700962, https://openalex.org/W4394999153, https://openalex.org/W4401454704, https://openalex.org/W2104925243, https://openalex.org/W2169450620, https://openalex.org/W4235886148, https://openalex.org/W2904551338, https://openalex.org/W4394817704, https://openalex.org/W4293161942, https://openalex.org/W1996856207, https://openalex.org/W4405238460, https://openalex.org/W3169925532, https://openalex.org/W3193609746, https://openalex.org/W4388233502, https://openalex.org/W4399467638, https://openalex.org/W3193419934, https://openalex.org/W4403921015, https://openalex.org/W4317830654, https://openalex.org/W3134482219, https://openalex.org/W2734605359, https://openalex.org/W2037150116, https://openalex.org/W2144692208, https://openalex.org/W2097018007, https://openalex.org/W2082493388, https://openalex.org/W1991148840, https://openalex.org/W2080338079, https://openalex.org/W2574854368, https://openalex.org/W2056242601, https://openalex.org/W1592418509, https://openalex.org/W2108000222, https://openalex.org/W2069104763, https://openalex.org/W2067442819, https://openalex.org/W1987511861, https://openalex.org/W2883798813, https://openalex.org/W3037086808, https://openalex.org/W2069138395, https://openalex.org/W4388398817, https://openalex.org/W4402024511, https://openalex.org/W4386116527, https://openalex.org/W2022452401, https://openalex.org/W4407362690, https://openalex.org/W2939094855, https://openalex.org/W2142965408, https://openalex.org/W2910326417, https://openalex.org/W4380986217, https://openalex.org/W4372331648, https://openalex.org/W4402903811, https://openalex.org/W4388818712, https://openalex.org/W4404392740, https://openalex.org/W4399321308, https://openalex.org/W4283378219, https://openalex.org/W3112963314, https://openalex.org/W4408488945, https://openalex.org/W4410497306, https://openalex.org/W4403921034, https://openalex.org/W4403284724, https://openalex.org/W2943993922, https://openalex.org/W2806699208, https://openalex.org/W4391404272, https://openalex.org/W2007187686, https://openalex.org/W2163230336, https://openalex.org/W3126210657, https://openalex.org/W4292560487, https://openalex.org/W4390699353, https://openalex.org/W2912980960, https://openalex.org/W3169865613, https://openalex.org/W2022334625, https://openalex.org/W3198357239, https://openalex.org/W4381435317 |
| referenced_works_count | 79 |
| abstract_inverted_index.a | 16, 58, 143, 148, 162, 212, 225 |
| abstract_inverted_index.By | 117 |
| abstract_inverted_index.In | 195 |
| abstract_inverted_index.We | 35 |
| abstract_inverted_index.an | 87, 94, 126 |
| abstract_inverted_index.as | 57 |
| abstract_inverted_index.by | 170 |
| abstract_inverted_index.in | 9, 63 |
| abstract_inverted_index.of | 21, 43, 151, 166, 182, 189, 228 |
| abstract_inverted_index.on | 224 |
| abstract_inverted_index.to | 40, 114, 138, 240 |
| abstract_inverted_index.we | 160 |
| abstract_inverted_index.HCC | 45, 92, 199 |
| abstract_inverted_index.and | 5, 12, 46, 66, 79, 108, 142, 180, 184, 191, 200 |
| abstract_inverted_index.has | 29 |
| abstract_inverted_index.not | 30 |
| abstract_inverted_index.one | 44, 47 |
| abstract_inverted_index.per | 52 |
| abstract_inverted_index.the | 27, 106 |
| abstract_inverted_index.two | 122 |
| abstract_inverted_index.yet | 15 |
| abstract_inverted_index.P450 | 173 |
| abstract_inverted_index.been | 32 |
| abstract_inverted_index.both | 157, 220 |
| abstract_inverted_index.cell | 77 |
| abstract_inverted_index.gene | 178 |
| abstract_inverted_index.heme | 190 |
| abstract_inverted_index.hub. | 215 |
| abstract_inverted_index.link | 236 |
| abstract_inverted_index.more | 109 |
| abstract_inverted_index.rare | 76 |
| abstract_inverted_index.that | 235 |
| abstract_inverted_index.this | 196 |
| abstract_inverted_index.were | 83 |
| abstract_inverted_index.with | 98, 208 |
| abstract_inverted_index.(HCC) | 4 |
| abstract_inverted_index.cells | 102, 112, 133 |
| abstract_inverted_index.genes | 51 |
| abstract_inverted_index.human | 64 |
| abstract_inverted_index.lipid | 192 |
| abstract_inverted_index.liver | 6, 28, 48, 119, 201 |
| abstract_inverted_index.local | 237 |
| abstract_inverted_index.niche | 150 |
| abstract_inverted_index.pilot | 197 |
| abstract_inverted_index.their | 22 |
| abstract_inverted_index.these | 217 |
| abstract_inverted_index.tumor | 23, 101, 132, 158, 221, 238 |
| abstract_inverted_index.types | 222 |
| abstract_inverted_index.where | 129 |
| abstract_inverted_index.which | 82, 146 |
| abstract_inverted_index.zone, | 128, 145 |
| abstract_inverted_index.(TMEs) | 25 |
| abstract_inverted_index.ALOX5, | 185 |
| abstract_inverted_index.Across | 156 |
| abstract_inverted_index.FLVCR1 | 183 |
| abstract_inverted_index.across | 105 |
| abstract_inverted_index.cells, | 141 |
| abstract_inverted_index.cells. | 155 |
| abstract_inverted_index.differ | 8 |
| abstract_inverted_index.direct | 17 |
| abstract_inverted_index.formed | 147 |
| abstract_inverted_index.niches | 239 |
| abstract_inverted_index.rates) | 56 |
| abstract_inverted_index.shared | 226 |
| abstract_inverted_index.showed | 121 |
| abstract_inverted_index.study, | 61, 198 |
| abstract_inverted_index.tissue | 107 |
| abstract_inverted_index.types, | 159 |
| abstract_inverted_index.within | 26 |
| abstract_inverted_index.zones. | 116 |
| abstract_inverted_index.>97% | 54 |
| abstract_inverted_index.Despite | 216 |
| abstract_inverted_index.Primary | 1 |
| abstract_inverted_index.against | 86 |
| abstract_inverted_index.applied | 36 |
| abstract_inverted_index.broadly | 103 |
| abstract_inverted_index.defined | 169 |
| abstract_inverted_index.further | 84 |
| abstract_inverted_index.lineage | 96 |
| abstract_inverted_index.mapping | 55 |
| abstract_inverted_index.ordered | 95 |
| abstract_inverted_index.origin, | 10 |
| abstract_inverted_index.pathway | 80 |
| abstract_inverted_index.program | 165, 227 |
| abstract_inverted_index.reduced | 171 |
| abstract_inverted_index.sample, | 53 |
| abstract_inverted_index.sharply | 123 |
| abstract_inverted_index.spatial | 19, 38, 206 |
| abstract_inverted_index.states, | 78 |
| abstract_inverted_index.targets | 234 |
| abstract_inverted_index.Methods: | 34 |
| abstract_inverted_index.Results: | 91 |
| abstract_inverted_index.TAM-rich | 135 |
| abstract_inverted_index.adjacent | 137 |
| abstract_inverted_index.compared | 85 |
| abstract_inverted_index.dataset. | 90 |
| abstract_inverted_index.detected | 161 |
| abstract_inverted_index.distinct | 74 |
| abstract_inverted_index.domains: | 125 |
| abstract_inverted_index.enhanced | 175 |
| abstract_inverted_index.invasion | 127 |
| abstract_inverted_index.occupied | 134 |
| abstract_inverted_index.revealed | 72 |
| abstract_inverted_index.rewiring | 188 |
| abstract_inverted_index.survival | 68 |
| abstract_inverted_index.systemic | 89, 241 |
| abstract_inverted_index.uniquely | 210 |
| abstract_inverted_index.carcinoma | 3 |
| abstract_inverted_index.conserved | 163 |
| abstract_inverted_index.contrast, | 118 |
| abstract_inverted_index.converged | 223 |
| abstract_inverted_index.datasets. | 69 |
| abstract_inverted_index.different | 205 |
| abstract_inverted_index.dispersed | 104 |
| abstract_inverted_index.displayed | 93 |
| abstract_inverted_index.harboring | 211 |
| abstract_inverted_index.localized | 115 |
| abstract_inverted_index.metabolic | 164, 229 |
| abstract_inverted_index.oxidative | 176 |
| abstract_inverted_index.potential | 232 |
| abstract_inverted_index.response, | 14 |
| abstract_inverted_index.rewiring, | 230 |
| abstract_inverted_index.spatially | 73 |
| abstract_inverted_index.specimens | 42 |
| abstract_inverted_index.stem-like | 131 |
| abstract_inverted_index.boundaries | 136 |
| abstract_inverted_index.clustering | 71 |
| abstract_inverted_index.comparison | 20 |
| abstract_inverted_index.contrasts, | 219 |
| abstract_inverted_index.cytochrome | 172 |
| abstract_inverted_index.metastases | 7, 120, 202, 209 |
| abstract_inverted_index.metastasis | 49 |
| abstract_inverted_index.performed. | 33 |
| abstract_inverted_index.plasticity | 144, 214 |
| abstract_inverted_index.previously | 31 |
| abstract_inverted_index.proteomics | 65 |
| abstract_inverted_index.reflecting | 186 |
| abstract_inverted_index.restricted | 113 |
| abstract_inverted_index.tumor-core | 140 |
| abstract_inverted_index.(>16,000 | 50 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.coordinated | 187 |
| abstract_inverted_index.expression, | 174, 179 |
| abstract_inverted_index.independent | 88 |
| abstract_inverted_index.metabolism. | 193 |
| abstract_inverted_index.patients’ | 67 |
| abstract_inverted_index.therapeutic | 13, 233 |
| abstract_inverted_index.transformed | 99 |
| abstract_inverted_index.Conclusions: | 194 |
| abstract_inverted_index.alterations, | 81 |
| abstract_inverted_index.demonstrated | 203 |
| abstract_inverted_index.fresh-frozen | 41 |
| abstract_inverted_index.highlighting | 231 |
| abstract_inverted_index.host–tumor | 242 |
| abstract_inverted_index.progression, | 11 |
| abstract_inverted_index.two-specimen | 60 |
| abstract_inverted_index.upregulation | 181 |
| abstract_inverted_index.“porphyrin | 167 |
| abstract_inverted_index.architecture, | 97 |
| abstract_inverted_index.compartments, | 75 |
| abstract_inverted_index.fundamentally | 204 |
| abstract_inverted_index.germline-like | 154 |
| abstract_inverted_index.heterogeneous | 149 |
| abstract_inverted_index.interactions. | 243 |
| abstract_inverted_index.overdrive,” | 168 |
| abstract_inverted_index.proliferative | 130 |
| abstract_inverted_index.architectures, | 207 |
| abstract_inverted_index.differentiated | 110 |
| abstract_inverted_index.hepatocellular | 2 |
| abstract_inverted_index.organizational | 218 |
| abstract_inverted_index.Transcriptional | 70 |
| abstract_inverted_index.cancer–testis | 152 |
| abstract_inverted_index.cross-validated | 62 |
| abstract_inverted_index.hepatocyte-like | 100 |
| abstract_inverted_index.high-definition | 37 |
| abstract_inverted_index.high-resolution | 18 |
| abstract_inverted_index.hypoxia-adapted | 139 |
| abstract_inverted_index.phosphorylation | 177 |
| abstract_inverted_index.transcriptomics | 39 |
| abstract_inverted_index.compartmentalized | 124 |
| abstract_inverted_index.microenvironments | 24 |
| abstract_inverted_index.antigen–positive | 153 |
| abstract_inverted_index.hepatocyte-derived | 111 |
| abstract_inverted_index.proof-of-principle | 59 |
| abstract_inverted_index.germline/neural-like | 213 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5075555324 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I2613432, https://openalex.org/I4210161586 |
| citation_normalized_percentile.value | 0.53916601 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |