Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus Article Swipe
Bernard Mulvey
,
Yi Wang
,
Heena R. Divecha
,
Svitlana V. Bach
,
Kelsey D. Montgomery
,
Sophia Cinquemani
,
A. Chandra
,
Yufeng Du
,
Ryan A. Miller
,
Joel E. Kleinman
,
Stephanie C. Page
,
Thomas M. Hyde
,
Keri Martinowich
,
Stephanie C. Hicks
,
Kasper D. Hansen
,
Kristen R. Maynard
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.12.07.627362
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.12.07.627362
The hypothalamus contains multiple regions, including the ventromedial hypothalamus (VMH) and arcuate (ARC), which are responsible for sex-differentiated functions such as endocrine signaling, metabolism, and reproductive behaviors. While molecular, anatomic, and sex-differentiated features of rodent hypothalamus are well-established, much less is known about these regions in humans. Here we provide a spatially-resolved single cell atlas of sex-differentially expressed (sex-DE) genes in human VMH and ARC. We identify neuronal populations governing hypothalamus-specific functions, define their spatial distributions, and show increased retinoid pathway gene expression compared to rodents. Within VMH and ARC, we find correlated autosomal expression differences localized to ESR1/TAC3 -expressing and CRHR2 -expressing neurons, and extensive sex-DE of genes linked to sex-biased disorders including autism, depression, and schizophrenia. Our molecular mapping of disease associations to hypothalamic cell types with established roles in sex-divergent physiology and behavior provides insights into mechanistic bases of sex bias in neurodevelopmental and neuropsychiatric disorders.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.12.07.627362
- OA Status
- green
- Cited By
- 6
- References
- 140
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405181260
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405181260Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.12.07.627362Digital Object Identifier
- Title
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Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamusWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-09Full publication date if available
- Authors
-
Bernard Mulvey, Yi Wang, Heena R. Divecha, Svitlana V. Bach, Kelsey D. Montgomery, Sophia Cinquemani, A. Chandra, Yufeng Du, Ryan A. Miller, Joel E. Kleinman, Stephanie C. Page, Thomas M. Hyde, Keri Martinowich, Stephanie C. Hicks, Kasper D. Hansen, Kristen R. MaynardList of authors in order
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https://doi.org/10.1101/2024.12.07.627362Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.1101/2024.12.07.627362Direct OA link when available
- Concepts
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Hypothalamus, Biology, Arc (geometry), Neuroscience, Gene, Sexual differentiation, Autism, Endocrinology, Internal medicine, Genetics, Psychology, Medicine, Developmental psychology, Geometry, MathematicsTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 6Per-year citation counts (last 5 years)
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140Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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