Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities Article Swipe
Álvaro López‐Janeiro
,
Eduardo Miraval Wong
,
Daniel Jiménez‐Sánchez
,
Carlos Ortíz-de-Solórzano
,
María D. Lozano
,
Álvaro Teijeira
,
Kurt A. Schalper
,
Ignacio Melero
,
Carlos E. de Andrea
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/jitc-2023-008589
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/jitc-2023-008589
Introduction The tissue immune microenvironment is associated with key aspects of tumor biology. The interaction between the immune system and cancer cells has predictive and prognostic potential across different tumor types. Spatially resolved tissue-based technologies allowed researchers to simultaneously quantify different immune populations in tumor samples. However, bare quantification fails to harness the spatial nature of tissue-based technologies. Tumor-immune interactions are associated with specific spatial patterns that can be measured. In recent years, several computational tools have been developed to increase our understanding of these spatial patterns. Topics covered In this review, we cover standard techniques as well as new advances in the field of spatial analysis of the immune microenvironment. We focused on marker quantification, spatial intratumor heterogeneity analysis, cell‒cell spatial interaction studies and neighborhood analyses.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/jitc-2023-008589
- https://jitc.bmj.com/content/12/5/e008589.full.pdf
- OA Status
- gold
- Cited By
- 8
- References
- 106
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399271663
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399271663Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1136/jitc-2023-008589Digital Object Identifier
- Title
-
Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densitiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-01Full publication date if available
- Authors
-
Álvaro López‐Janeiro, Eduardo Miraval Wong, Daniel Jiménez‐Sánchez, Carlos Ortíz-de-Solórzano, María D. Lozano, Álvaro Teijeira, Kurt A. Schalper, Ignacio Melero, Carlos E. de AndreaList of authors in order
- Landing page
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https://doi.org/10.1136/jitc-2023-008589Publisher landing page
- PDF URL
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https://jitc.bmj.com/content/12/5/e008589.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://jitc.bmj.com/content/12/5/e008589.full.pdfDirect OA link when available
- Concepts
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Tumor microenvironment, Immune system, Cell type, Cancer research, Medicine, Cell, Computational biology, Computer science, Biology, Immunology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
106Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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