Spatiotemporal Distribution Patterns of Osthole and Expression Correlation of the MOT1 Homologue in Cultivated Angelica biserrata Article Swipe
Kaidi Yu
,
Yuying Yang
,
Yuan Luo
,
Xiaogang Jiang
,
Jie Guo
,
Xiaoliang Guo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms262110746
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms262110746
Sustainable cultivation of Angelica biserrata, a medicinal species with a bioactive coumarin, Osthole, is hindered by inconsistent metabolite accumulation. To address this limitation, we integrated spatiotemporal metabolomics and transcriptomic analyses. Tissue-specific measurements revealed that root bark accumulates Osthole at 0.30 ± 0.15%, a concentration 11-fold higher compared to root pith and 15–30-fold higher compared to aerial organs. Over time, the Osthole content increased by 195% from September to December, with frost exposure further increasing the accumulation by an additional 170%. Germplasm screening identified an elite accession, AB-222, exhibiting 230% higher Osthole content compared to regional averages. Weighted gene co-expression network analysis identified a gene module strongly correlating with Osthole accumulation. Within this module, AbOMT1 (AB04G05077), an O-METHYLTRANSFERASE 1 (OMT1) homolog encoding an S-adenosyl methionine-dependent O-methyltransferase, was the top hub gene. AbOMT1 expression reflected Osthole dynamics both spatially (three-fold higher in root bark vs. root pith) and temporally. Module functional analysis revealed significant enrichment in phenylpropanoid and monoterpenoid biosynthesis pathways. Our results suggest AbOMT1 as a possible key molecular marker for Osthole accumulation, establish frost induction as a strong yield regulator, and suggest AB-222 as an elite germplasm resource.
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- en
- Landing Page
- https://doi.org/10.3390/ijms262110746
- https://www.mdpi.com/1422-0067/26/21/10746/pdf?version=1762334523
- OA Status
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- References
- 38
- OpenAlex ID
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https://openalex.org/W4415924678Canonical identifier for this work in OpenAlex
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- Title
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Spatiotemporal Distribution Patterns of Osthole and Expression Correlation of the MOT1 Homologue in Cultivated Angelica biserrataWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
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2025-11-05Full publication date if available
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Kaidi Yu, Yuying Yang, Yuan Luo, Xiaogang Jiang, Jie Guo, Xiaoliang GuoList of authors in order
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goldOpen access status per OpenAlex
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