Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation Article Swipe
Elliott D. SoRelle
,
Derek Yecies
,
Orly Liba
,
F. Chris Bennett
,
Claus Moritz Graef
,
Rebecca Dutta
,
Siddhartha S. Mitra
,
Lydia‐Marie Joubert
,
Samuel Cheshier
,
Gerald A. Grant
,
Adam de la Zerda
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.9b02656
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.9b02656
By their nature, tumors pose a set of profound challenges to the immune system with respect to cellular recognition and response coordination. Recent research indicates that leukocyte subpopulations, especially tumor-associated macrophages (TAMs), can exert substantial influence on the efficacy of various cancer immunotherapy treatment strategies. To better study and understand the roles of TAMs in determining immunotherapeutic outcomes, significant technical challenges associated with dynamically monitoring single cells of interest in relevant live animal models of solid tumors must be overcome. However, imaging techniques with the requisite combination of spatiotemporal resolution, cell-specific contrast, and sufficient signal-to-noise at increasing depths in tissue are exceedingly limited. Here we describe a method to enable high-resolution, wide-field, longitudinal imaging of TAMs based on speckle-modulating optical coherence tomography (SM-OCT) and spectral scattering from an optimized contrast agent. The approach's improvements to OCT detection sensitivity and noise reduction enabled high-resolution OCT-based observation of individual cells of a specific host lineage in live animals. We found that large gold nanorods (LGNRs) that exhibit a narrow-band, enhanced scattering cross-section can selectively label TAMs and activate microglia in an in vivo orthotopic murine model of glioblastoma multiforme. We demonstrated near real-time tracking of the migration of cells within these myeloid subpopulations. The intrinsic spatiotemporal resolution, imaging depth, and contrast sensitivity reported herein may facilitate detailed studies of the fundamental behaviors of TAMs and other leukocytes at the single-cell level in vivo, including intratumoral distribution heterogeneity and roles in modulating cancer proliferation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsnano.9b02656
- OA Status
- green
- Cited By
- 21
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2954889534
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2954889534Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acsnano.9b02656Digital Object Identifier
- Title
-
Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle ModulationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-06-25Full publication date if available
- Authors
-
Elliott D. SoRelle, Derek Yecies, Orly Liba, F. Chris Bennett, Claus Moritz Graef, Rebecca Dutta, Siddhartha S. Mitra, Lydia‐Marie Joubert, Samuel Cheshier, Gerald A. Grant, Adam de la ZerdaList of authors in order
- Landing page
-
https://doi.org/10.1021/acsnano.9b02656Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/8144904Direct OA link when available
- Concepts
-
Optical coherence tomography, In vivo, Preclinical imaging, Speckle pattern, Immune system, Immunotherapy, Cancer research, Computer science, Medicine, Biology, Optics, Physics, Immunology, Artificial intelligence, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2023: 4, 2022: 5, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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