Specialization of RNA Polymerase I in Comparison to Other Nuclear RNA Polymerases of Saccharomyces cerevisiae Article Swipe

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RNA polymerase I RNA polymerase Biology RNA polymerase III RNA Polymerase Transcription (linguistics) Chromatin Small nuclear RNA Saccharomyces cerevisiae Ribosomal RNA Transcription factories RNA polymerase II Cell biology Genetics RNA-dependent RNA polymerase DNA Yeast Gene Gene expression Promoter Philosophy Linguistics

Philipp Merkl , Christopher Schächner , Michael Pilsl , Katrin Schwank , Catharina Schmid , Gernot Längst , Philipp Milkereit , Joachim Griesenbeck , Herbert Tschochner ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1007/978-1-0716-2501-9_4 · OA: W4285048375

In archaea and bacteria the major classes of RNAs are synthesized by one DNA-dependent RNA polymerase (RNAP). In contrast, most eukaryotes have three highly specialized RNAPs to transcribe the nuclear genome. RNAP I synthesizes almost exclusively ribosomal (r)RNA, RNAP II synthesizes mRNA as well as many noncoding RNAs involved in RNA processing or RNA silencing pathways and RNAP III synthesizes mainly tRNA and 5S rRNA. This review discusses functional differences of the three nuclear core RNAPs in the yeast S. cerevisiae with a particular focus on RNAP I transcription of nucleolar ribosomal (r)DNA chromatin.