Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy? Article Swipe
Mervin Chávez-Castillo
,
Ángel Ortega
,
Lorena Cudris‐Torres
,
Pablo Durán
,
Milagros Rojas
,
Alexander Manzano
,
Bermary Garrido
,
Juan Salazar
,
Aljadis Silva
,
Diana Rojas-Gómez
,
Juan Bautista De Sanctis
,
Valmore Bermúdez
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms221910370
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms221910370
Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional analgesic treatments, specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for CP. These include various bioactive molecules such as resolvins, maresins, and protectins, derived from ω-3 polyunsaturated fatty acids (PUFAs); and lipoxins, produced from ω-6 PUFAs. Indeed, SPMs have been demonstrated to play a central role in the regulation and resolution of the inflammation associated with CP. Furthermore, these molecules can modulate neuroinflammation and thus inhibit central and peripheral sensitizations, as well as long-term potentiation, via immunomodulation and regulation of nociceptor activity and neuronal pathways. In this context, preclinical and clinical studies have evidenced that the use of SPMs is beneficial in CP-related disorders, including rheumatic diseases, migraine, neuropathies, and others. This review integrates current preclinical and clinical knowledge on the role of SPMs as a potential therapeutic tool for the management of patients with CP.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms221910370
- https://www.mdpi.com/1422-0067/22/19/10370/pdf?version=1632713838
- OA Status
- gold
- Cited By
- 43
- References
- 181
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3204417641
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3204417641Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms221910370Digital Object Identifier
- Title
-
Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?Work title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-26Full publication date if available
- Authors
-
Mervin Chávez-Castillo, Ángel Ortega, Lorena Cudris‐Torres, Pablo Durán, Milagros Rojas, Alexander Manzano, Bermary Garrido, Juan Salazar, Aljadis Silva, Diana Rojas-Gómez, Juan Bautista De Sanctis, Valmore BermúdezList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms221910370Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/22/19/10370/pdf?version=1632713838Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/22/19/10370/pdf?version=1632713838Direct OA link when available
- Concepts
-
Neuroinflammation, Medicine, Context (archaeology), Inflammation, Neuroscience, Lipid signaling, Adverse effect, Bioinformatics, Migraine, Chronic pain, Pharmacology, Immunology, Psychology, Biology, Physical therapy, Internal medicine, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
43Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 12, 2024: 9, 2023: 7, 2022: 14, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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181Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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