Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity Article Swipe
Mohammad Anwar Hossain
,
Abigail K. Mayo
,
Anirban Ghoshal
,
Sharon Taft-Benz
,
Elizabeth J. Anderson
,
Noah L. Morales
,
Katia D. Pressey
,
Ava M. Vargason
,
Kim L. R. Brouwer
,
Nathaniel J. Moorman
,
Mark T. Heise
,
Timothy M. Willson
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jmedchem.5c00825
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jmedchem.5c00825
RA-0002034 (1) is a potent covalent inhibitor targeting the nsP2 cysteine protease. The species-dependent pharmacokinetics and metabolism of 1 were investigated to evaluate its therapeutic potential. Pharmacokinetic profiling revealed rapid clearance in mice, predominantly mediated by glutathione S-transferase (GST)-catalyzed conjugation. This metabolic liability contrasted with slower clearance observed in human hepatocytes and preclinical species, such as rats, dogs, and monkeys. Cross-species studies confirmed the dominance of GST-driven metabolism in mice, whereas oxidative pathways were more pronounced in dogs. Despite rapid systemic clearance, 1 achieved antiviral efficacy in mice, reducing chikungunya (CHIKV) viral loads in multiple tissues. These cross-species pharmacokinetic and metabolism studies support the continued evaluation of 1 as a potential antialphaviral therapeutic to further define the contribution of hepatic and non-hepatic GST metabolism to its clearance in humans.
Related Topics
Concepts
Chemistry
In vivo
Enzyme inhibitor
Covalent bond
Metabolism
Protease inhibitor (pharmacology)
Biochemistry
Enzyme
Covalent binding
Protease
Organic chemistry
Genetics
Virus
Biology
Antiretroviral therapy
Viral load
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.jmedchem.5c00825
- OA Status
- hybrid
- Cited By
- 3
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410309472
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410309472Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acs.jmedchem.5c00825Digital Object Identifier
- Title
-
Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral ActivityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-12Full publication date if available
- Authors
-
Mohammad Anwar Hossain, Abigail K. Mayo, Anirban Ghoshal, Sharon Taft-Benz, Elizabeth J. Anderson, Noah L. Morales, Katia D. Pressey, Ava M. Vargason, Kim L. R. Brouwer, Nathaniel J. Moorman, Mark T. Heise, Timothy M. WillsonList of authors in order
- Landing page
-
https://doi.org/10.1021/acs.jmedchem.5c00825Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1021/acs.jmedchem.5c00825Direct OA link when available
- Concepts
-
Chemistry, In vivo, Enzyme inhibitor, Covalent bond, Metabolism, Protease inhibitor (pharmacology), Biochemistry, Enzyme, Covalent binding, Protease, Organic chemistry, Genetics, Virus, Biology, Antiretroviral therapy, Viral loadTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4410309472 |
|---|---|
| doi | https://doi.org/10.1021/acs.jmedchem.5c00825 |
| ids.doi | https://doi.org/10.1021/acs.jmedchem.5c00825 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40351160 |
| ids.openalex | https://openalex.org/W4410309472 |
| fwci | 8.04883388 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D006801 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Humans |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D004285 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Dogs |
| mesh[3].qualifier_ui | Q000494 |
| mesh[3].descriptor_ui | D000998 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | pharmacology |
| mesh[3].descriptor_name | Antiviral Agents |
| mesh[4].qualifier_ui | Q000493 |
| mesh[4].descriptor_ui | D000998 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | pharmacokinetics |
| mesh[4].descriptor_name | Antiviral Agents |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D000998 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Antiviral Agents |
| mesh[6].qualifier_ui | Q000737 |
| mesh[6].descriptor_ui | D000998 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | chemistry |
| mesh[6].descriptor_name | Antiviral Agents |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D051379 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Mice |
| mesh[8].qualifier_ui | Q000187 |
| mesh[8].descriptor_ui | D002646 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | drug effects |
| mesh[8].descriptor_name | Chikungunya virus |
| mesh[9].qualifier_ui | Q000201 |
| mesh[9].descriptor_ui | D002646 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | enzymology |
| mesh[9].descriptor_name | Chikungunya virus |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D051381 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Rats |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D013045 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Species Specificity |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008297 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Male |
| mesh[13].qualifier_ui | Q000037 |
| mesh[13].descriptor_ui | D017361 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | antagonists & inhibitors |
| mesh[13].descriptor_name | Viral Nonstructural Proteins |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D005982 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Glutathione Transferase |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D022781 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Hepatocytes |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D008252 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Macaca fascicularis |
| mesh[17].qualifier_ui | Q000494 |
| mesh[17].descriptor_ui | D015853 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | pharmacology |
| mesh[17].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[18].qualifier_ui | Q000493 |
| mesh[18].descriptor_ui | D015853 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | pharmacokinetics |
| mesh[18].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D015853 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D000818 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Animals |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D006801 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Humans |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D004285 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Dogs |
| mesh[23].qualifier_ui | Q000494 |
| mesh[23].descriptor_ui | D000998 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | pharmacology |
| mesh[23].descriptor_name | Antiviral Agents |
| mesh[24].qualifier_ui | Q000493 |
| mesh[24].descriptor_ui | D000998 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | pharmacokinetics |
| mesh[24].descriptor_name | Antiviral Agents |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D000998 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Antiviral Agents |
| mesh[26].qualifier_ui | Q000737 |
| mesh[26].descriptor_ui | D000998 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | chemistry |
| mesh[26].descriptor_name | Antiviral Agents |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D051379 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Mice |
| mesh[28].qualifier_ui | Q000187 |
| mesh[28].descriptor_ui | D002646 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | drug effects |
| mesh[28].descriptor_name | Chikungunya virus |
| mesh[29].qualifier_ui | Q000201 |
| mesh[29].descriptor_ui | D002646 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | enzymology |
| mesh[29].descriptor_name | Chikungunya virus |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D051381 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Rats |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D013045 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Species Specificity |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D008297 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Male |
| mesh[33].qualifier_ui | Q000037 |
| mesh[33].descriptor_ui | D017361 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | antagonists & inhibitors |
| mesh[33].descriptor_name | Viral Nonstructural Proteins |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D005982 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Glutathione Transferase |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D022781 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Hepatocytes |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D008252 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Macaca fascicularis |
| mesh[37].qualifier_ui | Q000494 |
| mesh[37].descriptor_ui | D015853 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | pharmacology |
| mesh[37].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[38].qualifier_ui | Q000493 |
| mesh[38].descriptor_ui | D015853 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | pharmacokinetics |
| mesh[38].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D015853 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D000818 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Animals |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D006801 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Humans |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D004285 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Dogs |
| mesh[43].qualifier_ui | Q000494 |
| mesh[43].descriptor_ui | D000998 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | pharmacology |
| mesh[43].descriptor_name | Antiviral Agents |
| mesh[44].qualifier_ui | Q000493 |
| mesh[44].descriptor_ui | D000998 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | pharmacokinetics |
| mesh[44].descriptor_name | Antiviral Agents |
| mesh[45].qualifier_ui | Q000378 |
| mesh[45].descriptor_ui | D000998 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | metabolism |
| mesh[45].descriptor_name | Antiviral Agents |
| mesh[46].qualifier_ui | Q000737 |
| mesh[46].descriptor_ui | D000998 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | chemistry |
| mesh[46].descriptor_name | Antiviral Agents |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D051379 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Mice |
| mesh[48].qualifier_ui | Q000187 |
| mesh[48].descriptor_ui | D002646 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | drug effects |
| mesh[48].descriptor_name | Chikungunya virus |
| mesh[49].qualifier_ui | Q000201 |
| mesh[49].descriptor_ui | D002646 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | enzymology |
| mesh[49].descriptor_name | Chikungunya virus |
| type | article |
| title | Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity |
| awards[0].id | https://openalex.org/G2003881057 |
| awards[0].funder_id | https://openalex.org/F4320326631 |
| awards[0].display_name | |
| awards[0].funder_award_id | 875510 |
| awards[0].funder_display_name | Innovative Medicines Initiative |
| awards[1].id | https://openalex.org/G408363823 |
| awards[1].funder_id | https://openalex.org/F4320337432 |
| awards[1].display_name | |
| awards[1].funder_award_id | 1U19AI17129201 |
| awards[1].funder_display_name | Center for Scientific Review |
| awards[2].id | https://openalex.org/G6006946825 |
| awards[2].funder_id | https://openalex.org/F4320319905 |
| awards[2].display_name | |
| awards[2].funder_award_id | OGI- 196 |
| awards[2].funder_display_name | Ontario Genomics Institute |
| biblio.issue | 10 |
| biblio.volume | 68 |
| biblio.last_page | 10485 |
| biblio.first_page | 10473 |
| topics[0].id | https://openalex.org/T12827 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Biochemical and Molecular Research |
| topics[1].id | https://openalex.org/T10526 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9994000196456909 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | HIV/AIDS drug development and treatment |
| topics[2].id | https://openalex.org/T11440 |
| topics[2].field.id | https://openalex.org/fields/16 |
| topics[2].field.display_name | Chemistry |
| topics[2].score | 0.991100013256073 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1605 |
| topics[2].subfield.display_name | Organic Chemistry |
| topics[2].display_name | Click Chemistry and Applications |
| funders[0].id | https://openalex.org/F4320306257 |
| funders[0].ror | https://ror.org/05kffp613 |
| funders[0].display_name | Boehringer Ingelheim |
| funders[1].id | https://openalex.org/F4320307115 |
| funders[1].ror | https://ror.org/00gtmwv55 |
| funders[1].display_name | Bristol-Myers Squibb |
| funders[2].id | https://openalex.org/F4320307765 |
| funders[2].ror | https://ror.org/01xdqrp08 |
| funders[2].display_name | Pfizer |
| funders[3].id | https://openalex.org/F4320307771 |
| funders[3].ror | https://ror.org/04hmn8g73 |
| funders[3].display_name | Bayer |
| funders[4].id | https://openalex.org/F4320310030 |
| funders[4].ror | https://ror.org/03bygaq51 |
| funders[4].display_name | Takeda Pharmaceuticals U.S.A. |
| funders[5].id | https://openalex.org/F4320310787 |
| funders[5].ror | https://ror.org/029s29983 |
| funders[5].display_name | Genome Canada |
| funders[6].id | https://openalex.org/F4320311647 |
| funders[6].ror | https://ror.org/04b2dty93 |
| funders[6].display_name | Merck KGaA |
| funders[7].id | https://openalex.org/F4320319905 |
| funders[7].ror | https://ror.org/00c68jz96 |
| funders[7].display_name | Ontario Genomics Institute |
| funders[8].id | https://openalex.org/F4320326631 |
| funders[8].ror | https://ror.org/019af4n30 |
| funders[8].display_name | Innovative Medicines Initiative |
| funders[9].id | https://openalex.org/F4320332193 |
| funders[9].ror | https://ror.org/04gndp242 |
| funders[9].display_name | Genentech |
| funders[10].id | https://openalex.org/F4320337432 |
| funders[10].ror | https://ror.org/04r5s4b52 |
| funders[10].display_name | Center for Scientific Review |
| funders[11].id | https://openalex.org/F4320337449 |
| funders[11].ror | https://ror.org/03qd7mz70 |
| funders[11].display_name | Janssen Biotech |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C185592680 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8767910599708557 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[0].display_name | Chemistry |
| concepts[1].id | https://openalex.org/C207001950 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7172378301620483 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q141124 |
| concepts[1].display_name | In vivo |
| concepts[2].id | https://openalex.org/C2776980637 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6504759192466736 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q427492 |
| concepts[2].display_name | Enzyme inhibitor |
| concepts[3].id | https://openalex.org/C180577832 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5897315740585327 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q127920 |
| concepts[3].display_name | Covalent bond |
| concepts[4].id | https://openalex.org/C62231903 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5636784434318542 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[4].display_name | Metabolism |
| concepts[5].id | https://openalex.org/C2781143361 |
| concepts[5].level | 5 |
| concepts[5].score | 0.5633683204650879 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q55761529 |
| concepts[5].display_name | Protease inhibitor (pharmacology) |
| concepts[6].id | https://openalex.org/C55493867 |
| concepts[6].level | 1 |
| concepts[6].score | 0.5158050060272217 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[6].display_name | Biochemistry |
| concepts[7].id | https://openalex.org/C181199279 |
| concepts[7].level | 2 |
| concepts[7].score | 0.49525871872901917 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[7].display_name | Enzyme |
| concepts[8].id | https://openalex.org/C3018522384 |
| concepts[8].level | 3 |
| concepts[8].score | 0.41791653633117676 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q127920 |
| concepts[8].display_name | Covalent binding |
| concepts[9].id | https://openalex.org/C2776714187 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4110787808895111 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q212410 |
| concepts[9].display_name | Protease |
| concepts[10].id | https://openalex.org/C178790620 |
| concepts[10].level | 1 |
| concepts[10].score | 0.07563900947570801 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[10].display_name | Organic chemistry |
| concepts[11].id | https://openalex.org/C54355233 |
| concepts[11].level | 1 |
| concepts[11].score | 0.06985452771186829 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[11].display_name | Genetics |
| concepts[12].id | https://openalex.org/C2522874641 |
| concepts[12].level | 2 |
| concepts[12].score | 0.05897340178489685 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[12].display_name | Virus |
| concepts[13].id | https://openalex.org/C86803240 |
| concepts[13].level | 0 |
| concepts[13].score | 0.05720973014831543 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[13].display_name | Biology |
| concepts[14].id | https://openalex.org/C2993143319 |
| concepts[14].level | 4 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q583050 |
| concepts[14].display_name | Antiretroviral therapy |
| concepts[15].id | https://openalex.org/C142462285 |
| concepts[15].level | 3 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q2528140 |
| concepts[15].display_name | Viral load |
| keywords[0].id | https://openalex.org/keywords/chemistry |
| keywords[0].score | 0.8767910599708557 |
| keywords[0].display_name | Chemistry |
| keywords[1].id | https://openalex.org/keywords/in-vivo |
| keywords[1].score | 0.7172378301620483 |
| keywords[1].display_name | In vivo |
| keywords[2].id | https://openalex.org/keywords/enzyme-inhibitor |
| keywords[2].score | 0.6504759192466736 |
| keywords[2].display_name | Enzyme inhibitor |
| keywords[3].id | https://openalex.org/keywords/covalent-bond |
| keywords[3].score | 0.5897315740585327 |
| keywords[3].display_name | Covalent bond |
| keywords[4].id | https://openalex.org/keywords/metabolism |
| keywords[4].score | 0.5636784434318542 |
| keywords[4].display_name | Metabolism |
| keywords[5].id | https://openalex.org/keywords/protease-inhibitor |
| keywords[5].score | 0.5633683204650879 |
| keywords[5].display_name | Protease inhibitor (pharmacology) |
| keywords[6].id | https://openalex.org/keywords/biochemistry |
| keywords[6].score | 0.5158050060272217 |
| keywords[6].display_name | Biochemistry |
| keywords[7].id | https://openalex.org/keywords/enzyme |
| keywords[7].score | 0.49525871872901917 |
| keywords[7].display_name | Enzyme |
| keywords[8].id | https://openalex.org/keywords/covalent-binding |
| keywords[8].score | 0.41791653633117676 |
| keywords[8].display_name | Covalent binding |
| keywords[9].id | https://openalex.org/keywords/protease |
| keywords[9].score | 0.4110787808895111 |
| keywords[9].display_name | Protease |
| keywords[10].id | https://openalex.org/keywords/organic-chemistry |
| keywords[10].score | 0.07563900947570801 |
| keywords[10].display_name | Organic chemistry |
| keywords[11].id | https://openalex.org/keywords/genetics |
| keywords[11].score | 0.06985452771186829 |
| keywords[11].display_name | Genetics |
| keywords[12].id | https://openalex.org/keywords/virus |
| keywords[12].score | 0.05897340178489685 |
| keywords[12].display_name | Virus |
| keywords[13].id | https://openalex.org/keywords/biology |
| keywords[13].score | 0.05720973014831543 |
| keywords[13].display_name | Biology |
| language | en |
| locations[0].id | doi:10.1021/acs.jmedchem.5c00825 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S162030435 |
| locations[0].source.issn | 0022-2623, 1520-4804 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0022-2623 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Medicinal Chemistry |
| locations[0].source.host_organization | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_name | American Chemical Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_lineage_names | American Chemical Society |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Medicinal Chemistry |
| locations[0].landing_page_url | https://doi.org/10.1021/acs.jmedchem.5c00825 |
| locations[1].id | pmid:40351160 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of medicinal chemistry |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40351160 |
| locations[2].id | pmh:oai:europepmc.org:10914332 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | cc-by-nc-nd |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12105008 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5084841942 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8684-8755 |
| authorships[0].author.display_name | Mohammad Anwar Hossain |
| authorships[0].countries | CA, US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2803004491 |
| authorships[0].affiliations[0].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[0].affiliations[1].raw_affiliation_string | READDI AViDD Center |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[0].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[0].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[0].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[0].institutions[0].type | nonprofit |
| authorships[0].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | Structural Genomics Consortium |
| authorships[0].institutions[1].id | https://openalex.org/I114027177 |
| authorships[0].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Mohammad Anwar Hossain |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[1].author.id | https://openalex.org/A5072837130 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Abigail K. Mayo |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[1].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[1].affiliations[1].raw_affiliation_string | Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy |
| authorships[1].institutions[0].id | https://openalex.org/I114027177 |
| authorships[1].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Abigail K. Mayo |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[2].author.id | https://openalex.org/A5023080172 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-9359-6074 |
| authorships[2].author.display_name | Anirban Ghoshal |
| authorships[2].countries | CA, US |
| authorships[2].affiliations[0].raw_affiliation_string | READDI AViDD Center |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I2803004491 |
| authorships[2].affiliations[1].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[2].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[2].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[2].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | Structural Genomics Consortium |
| authorships[2].institutions[1].id | https://openalex.org/I114027177 |
| authorships[2].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Anirban Ghoshal |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[3].author.id | https://openalex.org/A5065719654 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0965-8760 |
| authorships[3].author.display_name | Sharon Taft-Benz |
| authorships[3].countries | CA, US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2803004491 |
| authorships[3].affiliations[0].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[3].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[3].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[3].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[3].institutions[0].type | nonprofit |
| authorships[3].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[3].institutions[0].country_code | CA |
| authorships[3].institutions[0].display_name | Structural Genomics Consortium |
| authorships[3].institutions[1].id | https://openalex.org/I114027177 |
| authorships[3].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sharon Taft-Benz |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Microbiology and Immunology, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[4].author.id | https://openalex.org/A5027513530 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-7877-1639 |
| authorships[4].author.display_name | Elizabeth J. Anderson |
| authorships[4].countries | CA, US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[4].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I2803004491 |
| authorships[4].affiliations[1].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[4].affiliations[2].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[4].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[4].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[4].institutions[0].type | nonprofit |
| authorships[4].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | Structural Genomics Consortium |
| authorships[4].institutions[1].id | https://openalex.org/I114027177 |
| authorships[4].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Elizabeth Anderson |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Microbiology and Immunology, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[5].author.id | https://openalex.org/A5104336008 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Noah L. Morales |
| authorships[5].countries | CA, US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[5].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I2803004491 |
| authorships[5].affiliations[1].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[5].affiliations[2].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[5].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[5].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[5].institutions[0].type | nonprofit |
| authorships[5].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | Structural Genomics Consortium |
| authorships[5].institutions[1].id | https://openalex.org/I114027177 |
| authorships[5].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Noah L. Morales |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Microbiology and Immunology, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[6].author.id | https://openalex.org/A5017448548 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Katia D. Pressey |
| authorships[6].countries | CA, US |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I2803004491 |
| authorships[6].affiliations[1].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[6].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[6].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[6].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[6].institutions[0].type | nonprofit |
| authorships[6].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | Structural Genomics Consortium |
| authorships[6].institutions[1].id | https://openalex.org/I114027177 |
| authorships[6].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Katia D. Pressey |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Microbiology and Immunology, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[7].author.id | https://openalex.org/A5086285870 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6536-9998 |
| authorships[7].author.display_name | Ava M. Vargason |
| authorships[7].countries | CA, US |
| authorships[7].affiliations[0].raw_affiliation_string | Eshelman Innovation, UNC Eshelman School of Pharmacy |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[7].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I2803004491 |
| authorships[7].affiliations[2].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[7].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[7].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[7].institutions[0].country_code | CA |
| authorships[7].institutions[0].display_name | Structural Genomics Consortium |
| authorships[7].institutions[1].id | https://openalex.org/I114027177 |
| authorships[7].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Ava Vargason |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Eshelman Innovation, UNC Eshelman School of Pharmacy, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[8].author.id | https://openalex.org/A5056589677 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-1945-4929 |
| authorships[8].author.display_name | Kim L. R. Brouwer |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[8].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[8].affiliations[1].raw_affiliation_string | Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy |
| authorships[8].institutions[0].id | https://openalex.org/I114027177 |
| authorships[8].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Kim L. R. Brouwer |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[9].author.id | https://openalex.org/A5047825308 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-4952-6858 |
| authorships[9].author.display_name | Nathaniel J. Moorman |
| authorships[9].countries | CA, US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2803004491 |
| authorships[9].affiliations[0].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[9].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[9].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[9].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[9].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[9].institutions[0].type | nonprofit |
| authorships[9].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[9].institutions[0].country_code | CA |
| authorships[9].institutions[0].display_name | Structural Genomics Consortium |
| authorships[9].institutions[1].id | https://openalex.org/I114027177 |
| authorships[9].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[9].institutions[1].country_code | US |
| authorships[9].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Nathaniel J. Moorman |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Microbiology and Immunology, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[10].author.id | https://openalex.org/A5018924367 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-5829-8477 |
| authorships[10].author.display_name | Mark T. Heise |
| authorships[10].countries | CA, US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2803004491 |
| authorships[10].affiliations[0].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[10].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[10].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[10].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[10].affiliations[3].raw_affiliation_string | Department of Genetics |
| authorships[10].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[10].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[10].institutions[0].type | nonprofit |
| authorships[10].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[10].institutions[0].country_code | CA |
| authorships[10].institutions[0].display_name | Structural Genomics Consortium |
| authorships[10].institutions[1].id | https://openalex.org/I114027177 |
| authorships[10].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[10].institutions[1].country_code | US |
| authorships[10].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Mark T. Heise |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Genetics, Department of Microbiology and Immunology, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[11].author.id | https://openalex.org/A5081551458 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-4181-8223 |
| authorships[11].author.display_name | Timothy M. Willson |
| authorships[11].countries | CA, US |
| authorships[11].affiliations[0].raw_affiliation_string | READDI AViDD Center |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I2803004491 |
| authorships[11].affiliations[1].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[11].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[11].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[11].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[11].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[11].institutions[0].type | nonprofit |
| authorships[11].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[11].institutions[0].country_code | CA |
| authorships[11].institutions[0].display_name | Structural Genomics Consortium |
| authorships[11].institutions[1].id | https://openalex.org/I114027177 |
| authorships[11].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[11].institutions[1].country_code | US |
| authorships[11].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Timothy M. Willson |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1021/acs.jmedchem.5c00825 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12827 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Biochemical and Molecular Research |
| related_works | https://openalex.org/W4230319148, https://openalex.org/W2091035713, https://openalex.org/W2781122945, https://openalex.org/W2178059071, https://openalex.org/W1986564937, https://openalex.org/W2402288054, https://openalex.org/W2120338717, https://openalex.org/W2020436890, https://openalex.org/W1245749104, https://openalex.org/W1537553846 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1021/acs.jmedchem.5c00825 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S162030435 |
| best_oa_location.source.issn | 0022-2623, 1520-4804 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0022-2623 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Medicinal Chemistry |
| best_oa_location.source.host_organization | https://openalex.org/P4310320006 |
| best_oa_location.source.host_organization_name | American Chemical Society |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| best_oa_location.source.host_organization_lineage_names | American Chemical Society |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Medicinal Chemistry |
| best_oa_location.landing_page_url | https://doi.org/10.1021/acs.jmedchem.5c00825 |
| primary_location.id | doi:10.1021/acs.jmedchem.5c00825 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S162030435 |
| primary_location.source.issn | 0022-2623, 1520-4804 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0022-2623 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Medicinal Chemistry |
| primary_location.source.host_organization | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_name | American Chemical Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_lineage_names | American Chemical Society |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Medicinal Chemistry |
| primary_location.landing_page_url | https://doi.org/10.1021/acs.jmedchem.5c00825 |
| publication_date | 2025-05-12 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3181672614, https://openalex.org/W3189646261, https://openalex.org/W1233705598, https://openalex.org/W2023033918, https://openalex.org/W4293084539, https://openalex.org/W3158513244, https://openalex.org/W2540525654, https://openalex.org/W4312128809, https://openalex.org/W2010993054, https://openalex.org/W4403298165, https://openalex.org/W4402266268, https://openalex.org/W4408074144, https://openalex.org/W4400130384, https://openalex.org/W2020987809, https://openalex.org/W4387492877, https://openalex.org/W3025790143, https://openalex.org/W2119789069, https://openalex.org/W2527718275, https://openalex.org/W4402036235, https://openalex.org/W4286213884, https://openalex.org/W4400725705, https://openalex.org/W2056455169, https://openalex.org/W2028936105, https://openalex.org/W2055353351, https://openalex.org/W2039202029, https://openalex.org/W2130191568, https://openalex.org/W4395114602, https://openalex.org/W1607273785, https://openalex.org/W2769633170 |
| referenced_works_count | 29 |
| abstract_inverted_index.a | 3, 109 |
| abstract_inverted_index.as | 55, 108 |
| abstract_inverted_index.by | 35 |
| abstract_inverted_index.in | 31, 48, 68, 76, 86, 93, 127 |
| abstract_inverted_index.is | 2 |
| abstract_inverted_index.of | 17, 65, 106, 118 |
| abstract_inverted_index.to | 21, 113, 124 |
| abstract_inverted_index.GST | 122 |
| abstract_inverted_index.The | 12 |
| abstract_inverted_index.and | 15, 51, 58, 99, 120 |
| abstract_inverted_index.its | 23, 125 |
| abstract_inverted_index.the | 8, 63, 103, 116 |
| abstract_inverted_index.This | 40 |
| abstract_inverted_index.more | 74 |
| abstract_inverted_index.nsP2 | 9 |
| abstract_inverted_index.such | 54 |
| abstract_inverted_index.were | 19, 73 |
| abstract_inverted_index.with | 44 |
| abstract_inverted_index.These | 96 |
| abstract_inverted_index.dogs, | 57 |
| abstract_inverted_index.dogs. | 77 |
| abstract_inverted_index.human | 49 |
| abstract_inverted_index.loads | 92 |
| abstract_inverted_index.mice, | 32, 69, 87 |
| abstract_inverted_index.rapid | 29, 79 |
| abstract_inverted_index.rats, | 56 |
| abstract_inverted_index.viral | 91 |
| abstract_inverted_index.define | 115 |
| abstract_inverted_index.potent | 4 |
| abstract_inverted_index.slower | 45 |
| abstract_inverted_index.(CHIKV) | 90 |
| abstract_inverted_index.Despite | 78 |
| abstract_inverted_index.further | 114 |
| abstract_inverted_index.hepatic | 119 |
| abstract_inverted_index.humans. | 128 |
| abstract_inverted_index.studies | 61, 101 |
| abstract_inverted_index.support | 102 |
| abstract_inverted_index.whereas | 70 |
| abstract_inverted_index.<b>1</b> | 18, 82, 107 |
| abstract_inverted_index.achieved | 83 |
| abstract_inverted_index.covalent | 5 |
| abstract_inverted_index.cysteine | 10 |
| abstract_inverted_index.efficacy | 85 |
| abstract_inverted_index.evaluate | 22 |
| abstract_inverted_index.mediated | 34 |
| abstract_inverted_index.monkeys. | 59 |
| abstract_inverted_index.multiple | 94 |
| abstract_inverted_index.observed | 47 |
| abstract_inverted_index.pathways | 72 |
| abstract_inverted_index.reducing | 88 |
| abstract_inverted_index.revealed | 28 |
| abstract_inverted_index.species, | 53 |
| abstract_inverted_index.systemic | 80 |
| abstract_inverted_index.tissues. | 95 |
| abstract_inverted_index.antiviral | 84 |
| abstract_inverted_index.clearance | 30, 46, 126 |
| abstract_inverted_index.confirmed | 62 |
| abstract_inverted_index.continued | 104 |
| abstract_inverted_index.dominance | 64 |
| abstract_inverted_index.inhibitor | 6 |
| abstract_inverted_index.liability | 42 |
| abstract_inverted_index.metabolic | 41 |
| abstract_inverted_index.oxidative | 71 |
| abstract_inverted_index.potential | 110 |
| abstract_inverted_index.profiling | 27 |
| abstract_inverted_index.protease. | 11 |
| abstract_inverted_index.targeting | 7 |
| abstract_inverted_index.(<b>1</b>) | 1 |
| abstract_inverted_index.GST-driven | 66 |
| abstract_inverted_index.RA-0002034 | 0 |
| abstract_inverted_index.clearance, | 81 |
| abstract_inverted_index.contrasted | 43 |
| abstract_inverted_index.evaluation | 105 |
| abstract_inverted_index.metabolism | 16, 67, 100, 123 |
| abstract_inverted_index.potential. | 25 |
| abstract_inverted_index.pronounced | 75 |
| abstract_inverted_index.chikungunya | 89 |
| abstract_inverted_index.glutathione | 36 |
| abstract_inverted_index.hepatocytes | 50 |
| abstract_inverted_index.non-hepatic | 121 |
| abstract_inverted_index.preclinical | 52 |
| abstract_inverted_index.therapeutic | 24, 112 |
| abstract_inverted_index.conjugation. | 39 |
| abstract_inverted_index.contribution | 117 |
| abstract_inverted_index.investigated | 20 |
| abstract_inverted_index.Cross-species | 60 |
| abstract_inverted_index.cross-species | 97 |
| abstract_inverted_index.predominantly | 33 |
| abstract_inverted_index.antialphaviral | 111 |
| abstract_inverted_index.(GST)-catalyzed | 38 |
| abstract_inverted_index.Pharmacokinetic | 26 |
| abstract_inverted_index.pharmacokinetic | 98 |
| abstract_inverted_index.pharmacokinetics | 14 |
| abstract_inverted_index.species-dependent | 13 |
| abstract_inverted_index.<i>S</i>-transferase | 37 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 12 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5899999737739563 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.93746075 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |