Species-specific dynamics of specialized metabolism in germinating sorghum grain revealed by temporal and tissue-resolved transcriptomics and metabolomics Article Swipe
Huijun Liu
,
Nikola Mićić
,
Sara Miller
,
Christoph Crocoll
,
Nanna Bjarnholt
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.plaphy.2023.02.031
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.plaphy.2023.02.031
Seed germination is crucial for plant productivity, and the biochemical changes during germination affect seedling survival, plant health and yield. While the general metabolism of germination is extensively studied, the role of specialized metabolism is less investigated. We therefore analyzed the metabolism of the defense compound dhurrin during sorghum (Sorghum bicolor) grain germination and early seedling development. Dhurrin is a cyanogenic glucoside, which is catabolized into different bioactive compounds at other stages of plant development, but its fate and role during germination is unknown. We dissected sorghum grain into three different tissues and investigated dhurrin biosynthesis and catabolism at the transcriptomic, metabolomic and biochemical level. We further analyzed transcriptional signature differences of cyanogenic glucoside metabolism between sorghum and barley (Hordeum vulgare), which produces similar specialized metabolites. We found that dhurrin is de novo biosynthesized and catabolized in the growing embryonic axis as well as the scutellum and aleurone layer, two tissues otherwise mainly acknowledged for their involvement in release and transport of general metabolites from the endosperm to the embryonic axis. In contrast, genes encoding cyanogenic glucoside biosynthesis in barley are exclusively expressed in the embryonic axis. Glutathione transferase enzymes (GSTs) are involved in dhurrin catabolism and the tissue-resolved analysis of GST expression identified new pathway candidate genes and conserved GSTs as potentially important in cereal germination. Our study demonstrates a highly dynamic tissue- and species-specific specialized metabolism during cereal grain germination, highlighting the importance of tissue-resolved analyses and identification of specific roles of specialized metabolites in fundamental plant processes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.plaphy.2023.02.031
- OA Status
- hybrid
- Cited By
- 26
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4321189247Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.plaphy.2023.02.031Digital Object Identifier
- Title
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Species-specific dynamics of specialized metabolism in germinating sorghum grain revealed by temporal and tissue-resolved transcriptomics and metabolomicsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-17Full publication date if available
- Authors
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Huijun Liu, Nikola Mićić, Sara Miller, Christoph Crocoll, Nanna BjarnholtList of authors in order
- Landing page
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https://doi.org/10.1016/j.plaphy.2023.02.031Publisher landing page
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.plaphy.2023.02.031Direct OA link when available
- Concepts
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Germination, Biology, Scutellum, Aleurone, Catabolism, Seedling, Metabolism, Hordeum vulgare, Endosperm, Metabolomics, Biochemistry, Sorghum, Transcriptome, Metabolic pathway, Botany, Gene expression, Poaceae, Gene, Bioinformatics, EcologyTop concepts (fields/topics) attached by OpenAlex
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26Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 20, 2023: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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