Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff’s Base of Acenaphthaquinone Transition Metal Complexes Article Swipe
Khlood S. Abou‐Melha
,
Gamil A.A. Al‐Hazmi
,
Ismail Althagafi
,
Arwa Alharbi
,
Ali A. Keshk
,
Fathy Shaaban
,
Nashwa M. El‐Metwaly
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1155/2021/6674394
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1155/2021/6674394
The newly synthesized Schiff’s base derivative, N-allyl-2-(2-oxoacenaphthylen-1(2H)-ylidene)hydrazine-1-carbothioamide, has been characterized by different spectral techniques. Its reaction with Co(II), Ni(II), and Zn(II) acetate led to the formation of 1 : 1 (M:L) complexes. The IR and NMR spectral data revealed keto-thione form for the free ligand. On chelation with Co(II) and Ni(II), it behaved as mononegative and neutral tridentate via O, N1, and S donors, respectively, while it showed neutral bidentate mode via O and N1 atoms with Zn(II). The electronic spectra indicated that all the isolated complexes have an octahedral structure. The thermal gravimetric analyses confirmed the suggested formula and the presence of coordinated water molecules. The XRD pattern of the metal complexes showed that both Co(II) and Ni(II) have amorphous nature, while Zn(II) complex has monoclinic crystallinity with an average size of 9.10 nm. DFT modeling of the ligand and complexes supported the proposed structures. The calculated HOMO-LUMO energy gap, ΔEH-L, of the ligand complexes was 1.96–2.49 eV range where HAAT < Zn(II) < Ni(II) < Co(II). The antioxidant activity investigation showed that the ligand and Zn(II) complex have high activity than other complexes, 88.5 and 88.6%, respectively. Accordingly, the antitumor activity of isolated compounds was examined against the hepatocellular carcinoma cell line (HepG2), where both HAAT and Zn(II) complex exhibited very strong activity, IC50 6.45 ± 0.25 and 6.39 ± 0.18 μM, respectively.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2021/6674394
- https://downloads.hindawi.com/journals/bca/2021/6674394.pdf
- OA Status
- gold
- Cited By
- 19
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3138081477
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3138081477Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2021/6674394Digital Object Identifier
- Title
-
Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff’s Base of Acenaphthaquinone Transition Metal ComplexesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-22Full publication date if available
- Authors
-
Khlood S. Abou‐Melha, Gamil A.A. Al‐Hazmi, Ismail Althagafi, Arwa Alharbi, Ali A. Keshk, Fathy Shaaban, Nashwa M. El‐MetwalyList of authors in order
- Landing page
-
https://doi.org/10.1155/2021/6674394Publisher landing page
- PDF URL
-
https://downloads.hindawi.com/journals/bca/2021/6674394.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://downloads.hindawi.com/journals/bca/2021/6674394.pdfDirect OA link when available
- Concepts
-
Chemistry, Ligand (biochemistry), Schiff base, Denticity, HOMO/LUMO, Crystallography, Metal, Octahedron, Transition metal, Monoclinic crystal system, Coordination sphere, Molecule, Stereochemistry, Medicinal chemistry, Crystal structure, Organic chemistry, Catalysis, Receptor, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
19Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 3, 2022: 7, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
79Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3138081477 |
|---|---|
| doi | https://doi.org/10.1155/2021/6674394 |
| ids.doi | https://doi.org/10.1155/2021/6674394 |
| ids.mag | 3138081477 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33815493 |
| ids.openalex | https://openalex.org/W3138081477 |
| fwci | 2.12297722 |
| type | article |
| title | Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff’s Base of Acenaphthaquinone Transition Metal Complexes |
| biblio.issue | |
| biblio.volume | 2021 |
| biblio.last_page | 17 |
| biblio.first_page | 1 |
| grants[0].funder | https://openalex.org/F4320324433 |
| grants[0].award_id | R.G.P.1/236/41 |
| grants[0].funder_display_name | King Khalid University |
| topics[0].id | https://openalex.org/T10274 |
| topics[0].field.id | https://openalex.org/fields/16 |
| topics[0].field.display_name | Chemistry |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1605 |
| topics[0].subfield.display_name | Organic Chemistry |
| topics[0].display_name | Synthesis and biological activity |
| topics[1].id | https://openalex.org/T10163 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9995999932289124 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | Metal complexes synthesis and properties |
| topics[2].id | https://openalex.org/T12356 |
| topics[2].field.id | https://openalex.org/fields/30 |
| topics[2].field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| topics[2].score | 0.9994000196456909 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/3005 |
| topics[2].subfield.display_name | Toxicology |
| topics[2].display_name | Bioactive Compounds and Antitumor Agents |
| funders[0].id | https://openalex.org/F4320324433 |
| funders[0].ror | https://ror.org/052kwzs30 |
| funders[0].display_name | King Khalid University |
| is_xpac | False |
| apc_list.value | 1350 |
| apc_list.currency | USD |
| apc_list.value_usd | 1350 |
| apc_paid.value | 1350 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 1350 |
| concepts[0].id | https://openalex.org/C185592680 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9018608331680298 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[0].display_name | Chemistry |
| concepts[1].id | https://openalex.org/C116569031 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7065741419792175 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q899107 |
| concepts[1].display_name | Ligand (biochemistry) |
| concepts[2].id | https://openalex.org/C2776428424 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6829919815063477 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q2602701 |
| concepts[2].display_name | Schiff base |
| concepts[3].id | https://openalex.org/C178516000 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6324825882911682 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3023362 |
| concepts[3].display_name | Denticity |
| concepts[4].id | https://openalex.org/C14158195 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5420140027999878 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q899637 |
| concepts[4].display_name | HOMO/LUMO |
| concepts[5].id | https://openalex.org/C8010536 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4990105628967285 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q160398 |
| concepts[5].display_name | Crystallography |
| concepts[6].id | https://openalex.org/C544153396 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4884440004825592 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11426 |
| concepts[6].display_name | Metal |
| concepts[7].id | https://openalex.org/C198819137 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4726397395133972 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q188884 |
| concepts[7].display_name | Octahedron |
| concepts[8].id | https://openalex.org/C106773901 |
| concepts[8].level | 3 |
| concepts[8].score | 0.44414281845092773 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q19588 |
| concepts[8].display_name | Transition metal |
| concepts[9].id | https://openalex.org/C61276311 |
| concepts[9].level | 3 |
| concepts[9].score | 0.42604056000709534 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q624543 |
| concepts[9].display_name | Monoclinic crystal system |
| concepts[10].id | https://openalex.org/C11111787 |
| concepts[10].level | 3 |
| concepts[10].score | 0.41165563464164734 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q675972 |
| concepts[10].display_name | Coordination sphere |
| concepts[11].id | https://openalex.org/C32909587 |
| concepts[11].level | 2 |
| concepts[11].score | 0.4040069878101349 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11369 |
| concepts[11].display_name | Molecule |
| concepts[12].id | https://openalex.org/C71240020 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3513317406177521 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q186011 |
| concepts[12].display_name | Stereochemistry |
| concepts[13].id | https://openalex.org/C155647269 |
| concepts[13].level | 1 |
| concepts[13].score | 0.33440667390823364 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q243455 |
| concepts[13].display_name | Medicinal chemistry |
| concepts[14].id | https://openalex.org/C115624301 |
| concepts[14].level | 2 |
| concepts[14].score | 0.17734134197235107 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q895901 |
| concepts[14].display_name | Crystal structure |
| concepts[15].id | https://openalex.org/C178790620 |
| concepts[15].level | 1 |
| concepts[15].score | 0.09779942035675049 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[15].display_name | Organic chemistry |
| concepts[16].id | https://openalex.org/C161790260 |
| concepts[16].level | 2 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q82264 |
| concepts[16].display_name | Catalysis |
| concepts[17].id | https://openalex.org/C170493617 |
| concepts[17].level | 2 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[17].display_name | Receptor |
| concepts[18].id | https://openalex.org/C55493867 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[18].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/chemistry |
| keywords[0].score | 0.9018608331680298 |
| keywords[0].display_name | Chemistry |
| keywords[1].id | https://openalex.org/keywords/ligand |
| keywords[1].score | 0.7065741419792175 |
| keywords[1].display_name | Ligand (biochemistry) |
| keywords[2].id | https://openalex.org/keywords/schiff-base |
| keywords[2].score | 0.6829919815063477 |
| keywords[2].display_name | Schiff base |
| keywords[3].id | https://openalex.org/keywords/denticity |
| keywords[3].score | 0.6324825882911682 |
| keywords[3].display_name | Denticity |
| keywords[4].id | https://openalex.org/keywords/homo/lumo |
| keywords[4].score | 0.5420140027999878 |
| keywords[4].display_name | HOMO/LUMO |
| keywords[5].id | https://openalex.org/keywords/crystallography |
| keywords[5].score | 0.4990105628967285 |
| keywords[5].display_name | Crystallography |
| keywords[6].id | https://openalex.org/keywords/metal |
| keywords[6].score | 0.4884440004825592 |
| keywords[6].display_name | Metal |
| keywords[7].id | https://openalex.org/keywords/octahedron |
| keywords[7].score | 0.4726397395133972 |
| keywords[7].display_name | Octahedron |
| keywords[8].id | https://openalex.org/keywords/transition-metal |
| keywords[8].score | 0.44414281845092773 |
| keywords[8].display_name | Transition metal |
| keywords[9].id | https://openalex.org/keywords/monoclinic-crystal-system |
| keywords[9].score | 0.42604056000709534 |
| keywords[9].display_name | Monoclinic crystal system |
| keywords[10].id | https://openalex.org/keywords/coordination-sphere |
| keywords[10].score | 0.41165563464164734 |
| keywords[10].display_name | Coordination sphere |
| keywords[11].id | https://openalex.org/keywords/molecule |
| keywords[11].score | 0.4040069878101349 |
| keywords[11].display_name | Molecule |
| keywords[12].id | https://openalex.org/keywords/stereochemistry |
| keywords[12].score | 0.3513317406177521 |
| keywords[12].display_name | Stereochemistry |
| keywords[13].id | https://openalex.org/keywords/medicinal-chemistry |
| keywords[13].score | 0.33440667390823364 |
| keywords[13].display_name | Medicinal chemistry |
| keywords[14].id | https://openalex.org/keywords/crystal-structure |
| keywords[14].score | 0.17734134197235107 |
| keywords[14].display_name | Crystal structure |
| keywords[15].id | https://openalex.org/keywords/organic-chemistry |
| keywords[15].score | 0.09779942035675049 |
| keywords[15].display_name | Organic chemistry |
| language | en |
| locations[0].id | doi:10.1155/2021/6674394 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S113299162 |
| locations[0].source.issn | 1565-3633, 1687-479X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1565-3633 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Bioinorganic Chemistry and Applications |
| locations[0].source.host_organization | https://openalex.org/P4310319869 |
| locations[0].source.host_organization_name | Hindawi Publishing Corporation |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319869 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://downloads.hindawi.com/journals/bca/2021/6674394.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Bioinorganic Chemistry and Applications |
| locations[0].landing_page_url | https://doi.org/10.1155/2021/6674394 |
| locations[1].id | pmid:33815493 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Bioinorganic chemistry and applications |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33815493 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:8012121 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Bioinorg Chem Appl |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8012121 |
| locations[3].id | pmh:oai:doaj.org/article:39af5e77307947bbba5b13d4795ff6ec |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | cc-by-sa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Bioinorganic Chemistry and Applications, Vol 2021 (2021) |
| locations[3].landing_page_url | https://doaj.org/article/39af5e77307947bbba5b13d4795ff6ec |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5103107651 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1237-4099 |
| authorships[0].author.display_name | Khlood S. Abou‐Melha |
| authorships[0].countries | SA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I82952536 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Chemistry, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia |
| authorships[0].institutions[0].id | https://openalex.org/I82952536 |
| authorships[0].institutions[0].ror | https://ror.org/052kwzs30 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I82952536 |
| authorships[0].institutions[0].country_code | SA |
| authorships[0].institutions[0].display_name | King Khalid University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Khlood S. Abou Melha |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Chemistry, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia |
| authorships[1].author.id | https://openalex.org/A5026400434 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-7352-4831 |
| authorships[1].author.display_name | Gamil A.A. Al‐Hazmi |
| authorships[1].countries | SA, YE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I82952536 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Chemistry, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I36197038 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Chemistry, Taiz University, P.O. Box 82, Taiz, Yemen |
| authorships[1].institutions[0].id | https://openalex.org/I82952536 |
| authorships[1].institutions[0].ror | https://ror.org/052kwzs30 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I82952536 |
| authorships[1].institutions[0].country_code | SA |
| authorships[1].institutions[0].display_name | King Khalid University |
| authorships[1].institutions[1].id | https://openalex.org/I36197038 |
| authorships[1].institutions[1].ror | https://ror.org/03jwcxq96 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I36197038 |
| authorships[1].institutions[1].country_code | YE |
| authorships[1].institutions[1].display_name | Taiz University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Gamil A. Al-Hazmi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Chemistry, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia, Department of Chemistry, Taiz University, P.O. Box 82, Taiz, Yemen |
| authorships[2].author.id | https://openalex.org/A5001512863 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9343-2595 |
| authorships[2].author.display_name | Ismail Althagafi |
| authorships[2].countries | SA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I199693650 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Chemistry, Umm-Al-Qura University, Makkah, Saudi Arabia |
| authorships[2].institutions[0].id | https://openalex.org/I199693650 |
| authorships[2].institutions[0].ror | https://ror.org/01xjqrm90 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I199693650 |
| authorships[2].institutions[0].country_code | SA |
| authorships[2].institutions[0].display_name | Umm al-Qura University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ismail Althagafi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Chemistry, Umm-Al-Qura University, Makkah, Saudi Arabia |
| authorships[3].author.id | https://openalex.org/A5019506648 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1889-8918 |
| authorships[3].author.display_name | Arwa Alharbi |
| authorships[3].countries | SA |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I199693650 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Chemistry, Umm-Al-Qura University, Makkah, Saudi Arabia |
| authorships[3].institutions[0].id | https://openalex.org/I199693650 |
| authorships[3].institutions[0].ror | https://ror.org/01xjqrm90 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I199693650 |
| authorships[3].institutions[0].country_code | SA |
| authorships[3].institutions[0].display_name | Umm al-Qura University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Arwa Alharbi |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Chemistry, Umm-Al-Qura University, Makkah, Saudi Arabia |
| authorships[4].author.id | https://openalex.org/A5012358306 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-9636-0542 |
| authorships[4].author.display_name | Ali A. Keshk |
| authorships[4].countries | SA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I72264486 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Chemistry, College of Science, University of Tabuk, Tabuk, Saudi Arabia |
| authorships[4].institutions[0].id | https://openalex.org/I72264486 |
| authorships[4].institutions[0].ror | https://ror.org/04yej8x59 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I72264486 |
| authorships[4].institutions[0].country_code | SA |
| authorships[4].institutions[0].display_name | University of Tabuk |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ali A. Keshk |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Chemistry, College of Science, University of Tabuk, Tabuk, Saudi Arabia |
| authorships[5].author.id | https://openalex.org/A5045214210 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-9043-363X |
| authorships[5].author.display_name | Fathy Shaaban |
| authorships[5].countries | EG, SA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I199693650 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Environment and Health Research, Custodian of Two Holy Mosques Institute for Hajj and Umrah Research, Umm-Al-Qura University, Makkah, Saudi Arabia |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I4210112040 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Geomagnetic and Geoelectric, National Research Institute of Astronomy and Geophysics, Kafr Al Masallat, Egypt |
| authorships[5].institutions[0].id | https://openalex.org/I4210112040 |
| authorships[5].institutions[0].ror | https://ror.org/01cb2rv04 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210112040 |
| authorships[5].institutions[0].country_code | EG |
| authorships[5].institutions[0].display_name | National Research Institute of Astronomy and Geophysics |
| authorships[5].institutions[1].id | https://openalex.org/I199693650 |
| authorships[5].institutions[1].ror | https://ror.org/01xjqrm90 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I199693650 |
| authorships[5].institutions[1].country_code | SA |
| authorships[5].institutions[1].display_name | Umm al-Qura University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Fathy Shaaban |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Environment and Health Research, Custodian of Two Holy Mosques Institute for Hajj and Umrah Research, Umm-Al-Qura University, Makkah, Saudi Arabia, Department of Geomagnetic and Geoelectric, National Research Institute of Astronomy and Geophysics, Kafr Al Masallat, Egypt |
| authorships[6].author.id | https://openalex.org/A5022247649 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0619-6206 |
| authorships[6].author.display_name | Nashwa M. El‐Metwaly |
| authorships[6].countries | EG, SA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I159247623 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Chemistry, Mansoura University, Mansoura, Egypt |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I199693650 |
| authorships[6].affiliations[1].raw_affiliation_string | Department of Chemistry, Umm-Al-Qura University, Makkah, Saudi Arabia |
| authorships[6].institutions[0].id | https://openalex.org/I159247623 |
| authorships[6].institutions[0].ror | https://ror.org/01k8vtd75 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I159247623 |
| authorships[6].institutions[0].country_code | EG |
| authorships[6].institutions[0].display_name | Mansoura University |
| authorships[6].institutions[1].id | https://openalex.org/I199693650 |
| authorships[6].institutions[1].ror | https://ror.org/01xjqrm90 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I199693650 |
| authorships[6].institutions[1].country_code | SA |
| authorships[6].institutions[1].display_name | Umm al-Qura University |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Nashwa El-Metwaly |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Chemistry, Mansoura University, Mansoura, Egypt, Department of Chemistry, Umm-Al-Qura University, Makkah, Saudi Arabia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://downloads.hindawi.com/journals/bca/2021/6674394.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2021-03-29T00:00:00 |
| display_name | Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff’s Base of Acenaphthaquinone Transition Metal Complexes |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10274 |
| primary_topic.field.id | https://openalex.org/fields/16 |
| primary_topic.field.display_name | Chemistry |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1605 |
| primary_topic.subfield.display_name | Organic Chemistry |
| primary_topic.display_name | Synthesis and biological activity |
| related_works | https://openalex.org/W2605511881, https://openalex.org/W1955479687, https://openalex.org/W4399041043, https://openalex.org/W4246729339, https://openalex.org/W1975939164, https://openalex.org/W2058468260, https://openalex.org/W2153026539, https://openalex.org/W1980609617, https://openalex.org/W1964367409, https://openalex.org/W2153211456 |
| cited_by_count | 19 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 4 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 3 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 7 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1155/2021/6674394 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S113299162 |
| best_oa_location.source.issn | 1565-3633, 1687-479X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1565-3633 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Bioinorganic Chemistry and Applications |
| best_oa_location.source.host_organization | https://openalex.org/P4310319869 |
| best_oa_location.source.host_organization_name | Hindawi Publishing Corporation |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319869 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://downloads.hindawi.com/journals/bca/2021/6674394.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Bioinorganic Chemistry and Applications |
| best_oa_location.landing_page_url | https://doi.org/10.1155/2021/6674394 |
| primary_location.id | doi:10.1155/2021/6674394 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S113299162 |
| primary_location.source.issn | 1565-3633, 1687-479X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1565-3633 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Bioinorganic Chemistry and Applications |
| primary_location.source.host_organization | https://openalex.org/P4310319869 |
| primary_location.source.host_organization_name | Hindawi Publishing Corporation |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319869 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://downloads.hindawi.com/journals/bca/2021/6674394.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Bioinorganic Chemistry and Applications |
| primary_location.landing_page_url | https://doi.org/10.1155/2021/6674394 |
| publication_date | 2021-03-22 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2428985091, https://openalex.org/W2256814822, https://openalex.org/W2319575922, https://openalex.org/W1961584657, https://openalex.org/W2119881740, https://openalex.org/W2035238631, https://openalex.org/W161557697, https://openalex.org/W1995386153, https://openalex.org/W2004699826, https://openalex.org/W1984659484, https://openalex.org/W2053260796, https://openalex.org/W2080889704, https://openalex.org/W2469407756, https://openalex.org/W2003813885, https://openalex.org/W2326799277, https://openalex.org/W2346497934, https://openalex.org/W2958146346, https://openalex.org/W2551052896, https://openalex.org/W327629993, https://openalex.org/W1982847458, https://openalex.org/W2887182602, https://openalex.org/W2950420655, https://openalex.org/W2062010206, https://openalex.org/W1999967293, https://openalex.org/W2026021002, https://openalex.org/W2004085849, https://openalex.org/W2215223364, https://openalex.org/W2622980163, https://openalex.org/W2951018086, https://openalex.org/W2118838923, https://openalex.org/W2143981217, https://openalex.org/W2023271753, https://openalex.org/W2014068089, https://openalex.org/W2008708166, https://openalex.org/W2083228186, https://openalex.org/W2114918609, https://openalex.org/W1629179716, https://openalex.org/W1998722626, https://openalex.org/W1964663675, https://openalex.org/W871826591, https://openalex.org/W3044614946, https://openalex.org/W1489720399, https://openalex.org/W2953972292, https://openalex.org/W2946950935, https://openalex.org/W3040709694, https://openalex.org/W2033839177, https://openalex.org/W2016469137, https://openalex.org/W2110703655, https://openalex.org/W2086228145, https://openalex.org/W2767431648, https://openalex.org/W2546213644, https://openalex.org/W1983818212, https://openalex.org/W2606165964, https://openalex.org/W2040875144, https://openalex.org/W2090213688, https://openalex.org/W2013369456, https://openalex.org/W2084854782, https://openalex.org/W2016302042, https://openalex.org/W1968912645, https://openalex.org/W2516928462, https://openalex.org/W1999568327, https://openalex.org/W2802628799, https://openalex.org/W2789365672, https://openalex.org/W1976904646, https://openalex.org/W2087347895, https://openalex.org/W1554988598, https://openalex.org/W2744846210, https://openalex.org/W2956087767, https://openalex.org/W2030619273, https://openalex.org/W2417849925, https://openalex.org/W2324972292, https://openalex.org/W417289613, https://openalex.org/W1976106681, https://openalex.org/W2018152116, https://openalex.org/W3194992786, https://openalex.org/W2094498700, https://openalex.org/W1607426748, https://openalex.org/W407621793, https://openalex.org/W4229925216 |
| referenced_works_count | 79 |
| abstract_inverted_index.1 | 27, 29 |
| abstract_inverted_index.: | 28 |
| abstract_inverted_index.O | 72 |
| abstract_inverted_index.S | 62 |
| abstract_inverted_index.IR | 33 |
| abstract_inverted_index.N1 | 74 |
| abstract_inverted_index.O, | 59 |
| abstract_inverted_index.On | 45 |
| abstract_inverted_index.an | 88, 129 |
| abstract_inverted_index.as | 53 |
| abstract_inverted_index.by | 10 |
| abstract_inverted_index.eV | 158 |
| abstract_inverted_index.it | 51, 66 |
| abstract_inverted_index.of | 26, 102, 109, 132, 137, 152, 193 |
| abstract_inverted_index.to | 23 |
| abstract_inverted_index.± | 217, 221 |
| abstract_inverted_index.DFT | 135 |
| abstract_inverted_index.Its | 14 |
| abstract_inverted_index.N1, | 60 |
| abstract_inverted_index.NMR | 35 |
| abstract_inverted_index.The | 0, 32, 78, 91, 106, 146, 168 |
| abstract_inverted_index.XRD | 107 |
| abstract_inverted_index.all | 83 |
| abstract_inverted_index.and | 19, 34, 49, 55, 61, 73, 99, 117, 140, 176, 186, 208, 219 |
| abstract_inverted_index.for | 41 |
| abstract_inverted_index.has | 7, 125 |
| abstract_inverted_index.led | 22 |
| abstract_inverted_index.nm. | 134 |
| abstract_inverted_index.the | 24, 42, 84, 96, 100, 110, 138, 143, 153, 174, 190, 199 |
| abstract_inverted_index.via | 58, 71 |
| abstract_inverted_index.was | 156, 196 |
| abstract_inverted_index.< | 162, 164, 166 |
| abstract_inverted_index.0.18 | 222 |
| abstract_inverted_index.0.25 | 218 |
| abstract_inverted_index.6.39 | 220 |
| abstract_inverted_index.6.45 | 216 |
| abstract_inverted_index.88.5 | 185 |
| abstract_inverted_index.9.10 | 133 |
| abstract_inverted_index.HAAT | 161, 207 |
| abstract_inverted_index.IC50 | 215 |
| abstract_inverted_index.base | 4 |
| abstract_inverted_index.been | 8 |
| abstract_inverted_index.both | 115, 206 |
| abstract_inverted_index.cell | 202 |
| abstract_inverted_index.data | 37 |
| abstract_inverted_index.form | 40 |
| abstract_inverted_index.free | 43 |
| abstract_inverted_index.gap, | 150 |
| abstract_inverted_index.have | 87, 119, 179 |
| abstract_inverted_index.high | 180 |
| abstract_inverted_index.line | 203 |
| abstract_inverted_index.mode | 70 |
| abstract_inverted_index.size | 131 |
| abstract_inverted_index.than | 182 |
| abstract_inverted_index.that | 82, 114, 173 |
| abstract_inverted_index.very | 212 |
| abstract_inverted_index.with | 16, 47, 76, 128 |
| abstract_inverted_index.μM, | 223 |
| abstract_inverted_index.(M:L) | 30 |
| abstract_inverted_index.atoms | 75 |
| abstract_inverted_index.metal | 111 |
| abstract_inverted_index.newly | 1 |
| abstract_inverted_index.other | 183 |
| abstract_inverted_index.range | 159 |
| abstract_inverted_index.water | 104 |
| abstract_inverted_index.where | 160, 205 |
| abstract_inverted_index.while | 65, 122 |
| abstract_inverted_index.88.6%, | 187 |
| abstract_inverted_index.Co(II) | 48, 116 |
| abstract_inverted_index.Ni(II) | 118, 165 |
| abstract_inverted_index.Zn(II) | 20, 123, 163, 177, 209 |
| abstract_inverted_index.energy | 149 |
| abstract_inverted_index.ligand | 139, 154, 175 |
| abstract_inverted_index.showed | 67, 113, 172 |
| abstract_inverted_index.strong | 213 |
| abstract_inverted_index.Co(II), | 17 |
| abstract_inverted_index.Co(II). | 167 |
| abstract_inverted_index.Ni(II), | 18, 50 |
| abstract_inverted_index.Zn(II). | 77 |
| abstract_inverted_index.acetate | 21 |
| abstract_inverted_index.against | 198 |
| abstract_inverted_index.average | 130 |
| abstract_inverted_index.behaved | 52 |
| abstract_inverted_index.complex | 124, 178, 210 |
| abstract_inverted_index.donors, | 63 |
| abstract_inverted_index.formula | 98 |
| abstract_inverted_index.ligand. | 44 |
| abstract_inverted_index.nature, | 121 |
| abstract_inverted_index.neutral | 56, 68 |
| abstract_inverted_index.pattern | 108 |
| abstract_inverted_index.spectra | 80 |
| abstract_inverted_index.thermal | 92 |
| abstract_inverted_index.ΔEH-L, | 151 |
| abstract_inverted_index.(HepG2), | 204 |
| abstract_inverted_index.activity | 170, 181, 192 |
| abstract_inverted_index.analyses | 94 |
| abstract_inverted_index.examined | 197 |
| abstract_inverted_index.isolated | 85, 194 |
| abstract_inverted_index.modeling | 136 |
| abstract_inverted_index.presence | 101 |
| abstract_inverted_index.proposed | 144 |
| abstract_inverted_index.reaction | 15 |
| abstract_inverted_index.revealed | 38 |
| abstract_inverted_index.spectral | 12, 36 |
| abstract_inverted_index.HOMO-LUMO | 148 |
| abstract_inverted_index.activity, | 214 |
| abstract_inverted_index.amorphous | 120 |
| abstract_inverted_index.antitumor | 191 |
| abstract_inverted_index.bidentate | 69 |
| abstract_inverted_index.carcinoma | 201 |
| abstract_inverted_index.chelation | 46 |
| abstract_inverted_index.complexes | 86, 112, 141, 155 |
| abstract_inverted_index.compounds | 195 |
| abstract_inverted_index.confirmed | 95 |
| abstract_inverted_index.different | 11 |
| abstract_inverted_index.exhibited | 211 |
| abstract_inverted_index.formation | 25 |
| abstract_inverted_index.indicated | 81 |
| abstract_inverted_index.suggested | 97 |
| abstract_inverted_index.supported | 142 |
| abstract_inverted_index.Schiff’s | 3 |
| abstract_inverted_index.calculated | 147 |
| abstract_inverted_index.complexes, | 184 |
| abstract_inverted_index.complexes. | 31 |
| abstract_inverted_index.electronic | 79 |
| abstract_inverted_index.molecules. | 105 |
| abstract_inverted_index.monoclinic | 126 |
| abstract_inverted_index.octahedral | 89 |
| abstract_inverted_index.structure. | 90 |
| abstract_inverted_index.tridentate | 57 |
| abstract_inverted_index.1.96–2.49 | 157 |
| abstract_inverted_index.antioxidant | 169 |
| abstract_inverted_index.coordinated | 103 |
| abstract_inverted_index.derivative, | 5 |
| abstract_inverted_index.gravimetric | 93 |
| abstract_inverted_index.keto-thione | 39 |
| abstract_inverted_index.structures. | 145 |
| abstract_inverted_index.synthesized | 2 |
| abstract_inverted_index.techniques. | 13 |
| abstract_inverted_index.Accordingly, | 189 |
| abstract_inverted_index.mononegative | 54 |
| abstract_inverted_index.characterized | 9 |
| abstract_inverted_index.crystallinity | 127 |
| abstract_inverted_index.investigation | 171 |
| abstract_inverted_index.respectively, | 64 |
| abstract_inverted_index.respectively. | 188, 224 |
| abstract_inverted_index.hepatocellular | 200 |
| abstract_inverted_index.N-allyl-2-(2-oxoacenaphthylen-1(2H)-ylidene)hydrazine-1-carbothioamide, | 6 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 93 |
| corresponding_author_ids | https://openalex.org/A5022247649 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I159247623, https://openalex.org/I199693650 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.83468656 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |