Sperm miR‐26a‐5p and its target PTEN transcripts content in men with unexplained infertility Article Swipe
Mehran Dorostghoal
,
Hamid Galehdari
,
Farideh Moramezi
,
Reza Danyari
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/andr.12801
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/andr.12801
Background Recent evidence suggests that routine semen analysis has limited power to predict male fertility. Several efforts have been made to best discriminate between fertile and subfertile men using several sperm features. So, there is a need to more reliable assays for providing molecular data to evaluate sperm quality and predict male fertility. Objectives Present study aimed to investigate relationship between sperm miR‐26a‐5p and its target PTEN transcript content and sperm parameters in unexplained infertile and healthy fertile men. Materials and methods Sperm parameters and transcript content of miR‐26a‐5p and PTEN in ejaculated spermatozoa were assessed in fertile (n = 15) and normozoospermic infertile (n = 15) men. Results Sperm transcript levels of miR‐26a‐5p were lower in unexplained infertile men than in fertile controls ( P = .021). High sperm PTEN expression is correlated with low miR‐26a‐5p transcript levels in ejaculated spermatozoa. High levels of sperm miR‐26a‐5p transcript were associated with high sperm motility and normal morphology. Receiver operating characteristic curve (ROC) analysis indicated miR‐26a‐5p has a fairly good diagnostic value to distinguish fertile and unexplained infertile men with an area under curve (AUC) of 0.747 (95% confidence interval: 0.560‐0.933; P = .021). Discussion This study suggests that sperm miR‐26a‐5p and its target PTEN transcript content may contribute to infertility etiology in unexplained infertile patients. Conclusion miR‐26a‐5p has a potential to use as a diagnostic biomarker and provide new therapeutic approaches for male infertility.
Related Topics
Concepts
Sperm
PTEN
Andrology
Unexplained infertility
Male infertility
Infertility
Fertility
Semen
Biology
Sperm motility
Semen analysis
Medicine
Gynecology
Population
Genetics
Apoptosis
Pregnancy
PI3K/AKT/mTOR pathway
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/andr.12801
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/andr.12801
- OA Status
- bronze
- Cited By
- 22
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3017383035
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3017383035Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/andr.12801Digital Object Identifier
- Title
-
Sperm miR‐26a‐5p and its target PTEN transcripts content in men with unexplained infertilityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-04-20Full publication date if available
- Authors
-
Mehran Dorostghoal, Hamid Galehdari, Farideh Moramezi, Reza DanyariList of authors in order
- Landing page
-
https://doi.org/10.1111/andr.12801Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/andr.12801Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/andr.12801Direct OA link when available
- Concepts
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Sperm, PTEN, Andrology, Unexplained infertility, Male infertility, Infertility, Fertility, Semen, Biology, Sperm motility, Semen analysis, Medicine, Gynecology, Population, Genetics, Apoptosis, Pregnancy, PI3K/AKT/mTOR pathway, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 9, 2023: 6, 2021: 5, 2020: 1Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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