Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure Article Swipe

View

Kengo Yoshida , Zhenqiu Liu , Yoshiko Kubo , Masahiko Miura , Mika Yamaoka , Hiroko Nagamura , Munechika Misumi , Yoichiro Kusunoki ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1016/j.exger.2024.112646

Related Topics

Concepts

Transcriptome Spermidine Downregulation and upregulation CD8 Biology Ionizing radiation Andrology Inflammation Cell Population Molecular biology Immunology Cancer research Cell biology Irradiation Gene expression Gene Immune system Medicine Biochemistry Enzyme Physics Nuclear physics Environmental health

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.exger.2024.112646
OA Status: gold
Cited By: 1
References: 30
Related Works: 10
OpenAlex ID: https://openalex.org/W4405168228

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4405168228

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1016/j.exger.2024.112646

Digital Object Identifier
Title: Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2024

Year of publication
Publication date: 2024-12-18

Full publication date if available
Authors: Kengo Yoshida, Zhenqiu Liu, Yoshiko Kubo, Masahiko Miura, Mika Yamaoka, Hiroko Nagamura, Munechika Misumi, Yoichiro Kusunoki

List of authors in order
Landing page: https://doi.org/10.1016/j.exger.2024.112646

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1016/j.exger.2024.112646

Direct OA link when available
Concepts: Transcriptome, Spermidine, Downregulation and upregulation, CD8, Biology, Ionizing radiation, Andrology, Inflammation, Cell, Population, Molecular biology, Immunology, Cancer research, Cell biology, Irradiation, Gene expression, Gene, Immune system, Medicine, Biochemistry, Enzyme, Physics, Nuclear physics, Environmental health

Top concepts (fields/topics) attached by OpenAlex
Cited by: 1

Total citation count in OpenAlex
Citations by year (recent): 2025: 1

Per-year citation counts (last 5 years)
References (count): 30

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4405168228
doi	https://doi.org/10.1016/j.exger.2024.112646
ids.doi	https://doi.org/10.1016/j.exger.2024.112646
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/39643253
ids.openalex	https://openalex.org/W4405168228
fwci	0.48024723
mesh[0].qualifier_ui
mesh[0].descriptor_ui	D000818
mesh[0].is_major_topic	False
mesh[0].qualifier_name
mesh[0].descriptor_name	Animals
mesh[1].qualifier_ui
mesh[1].descriptor_ui	D051379
mesh[1].is_major_topic	False
mesh[1].qualifier_name
mesh[1].descriptor_name	Mice
mesh[2].qualifier_ui	Q000494
mesh[2].descriptor_ui	D013095
mesh[2].is_major_topic	True
mesh[2].qualifier_name	pharmacology
mesh[2].descriptor_name	Spermidine
mesh[3].qualifier_ui	Q000187
mesh[3].descriptor_ui	D016922
mesh[3].is_major_topic	True
mesh[3].qualifier_name	drug effects
mesh[3].descriptor_name	Cellular Senescence
mesh[4].qualifier_ui	Q000528
mesh[4].descriptor_ui	D016922
mesh[4].is_major_topic	True
mesh[4].qualifier_name	radiation effects
mesh[4].descriptor_name	Cellular Senescence
mesh[5].qualifier_ui
mesh[5].descriptor_ui	D008810
mesh[5].is_major_topic	False
mesh[5].qualifier_name
mesh[5].descriptor_name	Mice, Inbred C57BL
mesh[6].qualifier_ui
mesh[6].descriptor_ui	D008297
mesh[6].is_major_topic	False
mesh[6].qualifier_name
mesh[6].descriptor_name	Male
mesh[7].qualifier_ui	Q000187
mesh[7].descriptor_ui	D013950
mesh[7].is_major_topic	False
mesh[7].qualifier_name	drug effects
mesh[7].descriptor_name	Thymus Gland
mesh[8].qualifier_ui	Q000528
mesh[8].descriptor_ui	D013950
mesh[8].is_major_topic	False
mesh[8].qualifier_name	radiation effects
mesh[8].descriptor_name	Thymus Gland
mesh[9].qualifier_ui	Q000187
mesh[9].descriptor_ui	D060168
mesh[9].is_major_topic	False
mesh[9].qualifier_name	drug effects
mesh[9].descriptor_name	Thymocytes
mesh[10].qualifier_ui	Q000528
mesh[10].descriptor_ui	D060168
mesh[10].is_major_topic	False
mesh[10].qualifier_name	radiation effects
mesh[10].descriptor_name	Thymocytes
mesh[11].qualifier_ui	Q000378
mesh[11].descriptor_ui	D060168
mesh[11].is_major_topic	False
mesh[11].qualifier_name	metabolism
mesh[11].descriptor_name	Thymocytes
mesh[12].qualifier_ui	Q000009
mesh[12].descriptor_ui	D000069079
mesh[12].is_major_topic	False
mesh[12].qualifier_name	adverse effects
mesh[12].descriptor_name	Radiation Exposure
mesh[13].qualifier_ui
mesh[13].descriptor_ui	D000375
mesh[13].is_major_topic	False
mesh[13].qualifier_name
mesh[13].descriptor_name	Aging
mesh[14].qualifier_ui
mesh[14].descriptor_ui	D059467
mesh[14].is_major_topic	False
mesh[14].qualifier_name
mesh[14].descriptor_name	Transcriptome
mesh[15].qualifier_ui	Q000187
mesh[15].descriptor_ui	D018414
mesh[15].is_major_topic	False
mesh[15].qualifier_name	drug effects
mesh[15].descriptor_name	CD8-Positive T-Lymphocytes
mesh[16].qualifier_ui	Q000187
mesh[16].descriptor_ui	D038041
mesh[16].is_major_topic	False
mesh[16].qualifier_name	drug effects
mesh[16].descriptor_name	Lymphopoiesis
mesh[17].qualifier_ui
mesh[17].descriptor_ui	D000818
mesh[17].is_major_topic	False
mesh[17].qualifier_name
mesh[17].descriptor_name	Animals
mesh[18].qualifier_ui
mesh[18].descriptor_ui	D051379
mesh[18].is_major_topic	False
mesh[18].qualifier_name
mesh[18].descriptor_name	Mice
mesh[19].qualifier_ui	Q000494
mesh[19].descriptor_ui	D013095
mesh[19].is_major_topic	True
mesh[19].qualifier_name	pharmacology
mesh[19].descriptor_name	Spermidine
mesh[20].qualifier_ui	Q000187
mesh[20].descriptor_ui	D016922
mesh[20].is_major_topic	True
mesh[20].qualifier_name	drug effects
mesh[20].descriptor_name	Cellular Senescence
mesh[21].qualifier_ui	Q000528
mesh[21].descriptor_ui	D016922
mesh[21].is_major_topic	True
mesh[21].qualifier_name	radiation effects
mesh[21].descriptor_name	Cellular Senescence
mesh[22].qualifier_ui
mesh[22].descriptor_ui	D008810
mesh[22].is_major_topic	False
mesh[22].qualifier_name
mesh[22].descriptor_name	Mice, Inbred C57BL
mesh[23].qualifier_ui
mesh[23].descriptor_ui	D008297
mesh[23].is_major_topic	False
mesh[23].qualifier_name
mesh[23].descriptor_name	Male
mesh[24].qualifier_ui	Q000187
mesh[24].descriptor_ui	D013950
mesh[24].is_major_topic	False
mesh[24].qualifier_name	drug effects
mesh[24].descriptor_name	Thymus Gland
mesh[25].qualifier_ui	Q000528
mesh[25].descriptor_ui	D013950
mesh[25].is_major_topic	False
mesh[25].qualifier_name	radiation effects
mesh[25].descriptor_name	Thymus Gland
mesh[26].qualifier_ui	Q000187
mesh[26].descriptor_ui	D060168
mesh[26].is_major_topic	False
mesh[26].qualifier_name	drug effects
mesh[26].descriptor_name	Thymocytes
mesh[27].qualifier_ui	Q000528
mesh[27].descriptor_ui	D060168
mesh[27].is_major_topic	False
mesh[27].qualifier_name	radiation effects
mesh[27].descriptor_name	Thymocytes
mesh[28].qualifier_ui	Q000378
mesh[28].descriptor_ui	D060168
mesh[28].is_major_topic	False
mesh[28].qualifier_name	metabolism
mesh[28].descriptor_name	Thymocytes
mesh[29].qualifier_ui	Q000009
mesh[29].descriptor_ui	D000069079
mesh[29].is_major_topic	False
mesh[29].qualifier_name	adverse effects
mesh[29].descriptor_name	Radiation Exposure
mesh[30].qualifier_ui
mesh[30].descriptor_ui	D000375
mesh[30].is_major_topic	False
mesh[30].qualifier_name
mesh[30].descriptor_name	Aging
mesh[31].qualifier_ui
mesh[31].descriptor_ui	D059467
mesh[31].is_major_topic	False
mesh[31].qualifier_name
mesh[31].descriptor_name	Transcriptome
mesh[32].qualifier_ui	Q000187
mesh[32].descriptor_ui	D018414
mesh[32].is_major_topic	False
mesh[32].qualifier_name	drug effects
mesh[32].descriptor_name	CD8-Positive T-Lymphocytes
mesh[33].qualifier_ui	Q000187
mesh[33].descriptor_ui	D038041
mesh[33].is_major_topic	False
mesh[33].qualifier_name	drug effects
mesh[33].descriptor_name	Lymphopoiesis
type	article
title	Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure
biblio.issue
biblio.volume	199
biblio.last_page	112646
biblio.first_page	112646
grants[0].funder	https://openalex.org/F4320306084
grants[0].award_id
grants[0].funder_display_name	U.S. Department of Energy
grants[1].funder	https://openalex.org/F4320321945
grants[1].award_id
grants[1].funder_display_name	Ministry of Health, Labour and Welfare
topics[0].id	https://openalex.org/T11924
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.9990000128746033
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	Polyamine Metabolism and Applications
topics[1].id	https://openalex.org/T11020
topics[1].field.id	https://openalex.org/fields/24
topics[1].field.display_name	Immunology and Microbiology
topics[1].score	0.9943000078201294
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/2403
topics[1].subfield.display_name	Immunology
topics[1].display_name	Immune Cell Function and Interaction
topics[2].id	https://openalex.org/T10342
topics[2].field.id	https://openalex.org/fields/28
topics[2].field.display_name	Neuroscience
topics[2].score	0.9639000296592712
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/2807
topics[2].subfield.display_name	Endocrine and Autonomic Systems
topics[2].display_name	Circadian rhythm and melatonin
funders[0].id	https://openalex.org/F4320306084
funders[0].ror	https://ror.org/01bj3aw27
funders[0].display_name	U.S. Department of Energy
funders[1].id	https://openalex.org/F4320321945
funders[1].ror	https://ror.org/03mwa7s65
funders[1].display_name	Ministry of Health, Labour and Welfare
is_xpac	False
apc_list.value	2800
apc_list.currency	USD
apc_list.value_usd	2800
apc_paid.value	2800
apc_paid.currency	USD
apc_paid.value_usd	2800
concepts[0].id	https://openalex.org/C162317418
concepts[0].level	4
concepts[0].score	0.6018326282501221
concepts[0].wikidata	https://www.wikidata.org/wiki/Q252857
concepts[0].display_name	Transcriptome
concepts[1].id	https://openalex.org/C2777497464
concepts[1].level	3
concepts[1].score	0.5948822498321533
concepts[1].wikidata	https://www.wikidata.org/wiki/Q418834
concepts[1].display_name	Spermidine
concepts[2].id	https://openalex.org/C127561419
concepts[2].level	3
concepts[2].score	0.5912579894065857
concepts[2].wikidata	https://www.wikidata.org/wiki/Q224527
concepts[2].display_name	Downregulation and upregulation
concepts[3].id	https://openalex.org/C167672396
concepts[3].level	3
concepts[3].score	0.5817707180976868
concepts[3].wikidata	https://www.wikidata.org/wiki/Q417800
concepts[3].display_name	CD8
concepts[4].id	https://openalex.org/C86803240
concepts[4].level	0
concepts[4].score	0.5095767974853516
concepts[4].wikidata	https://www.wikidata.org/wiki/Q420
concepts[4].display_name	Biology
concepts[5].id	https://openalex.org/C18231593
concepts[5].level	3
concepts[5].score	0.4667969346046448
concepts[5].wikidata	https://www.wikidata.org/wiki/Q186161
concepts[5].display_name	Ionizing radiation
concepts[6].id	https://openalex.org/C16685009
concepts[6].level	1
concepts[6].score	0.45991790294647217
concepts[6].wikidata	https://www.wikidata.org/wiki/Q335057
concepts[6].display_name	Andrology
concepts[7].id	https://openalex.org/C2776914184
concepts[7].level	2
concepts[7].score	0.44906890392303467
concepts[7].wikidata	https://www.wikidata.org/wiki/Q101991
concepts[7].display_name	Inflammation
concepts[8].id	https://openalex.org/C1491633281
concepts[8].level	2
concepts[8].score	0.44783735275268555
concepts[8].wikidata	https://www.wikidata.org/wiki/Q7868
concepts[8].display_name	Cell
concepts[9].id	https://openalex.org/C2908647359
concepts[9].level	2
concepts[9].score	0.4218023121356964
concepts[9].wikidata	https://www.wikidata.org/wiki/Q2625603
concepts[9].display_name	Population
concepts[10].id	https://openalex.org/C153911025
concepts[10].level	1
concepts[10].score	0.3700915575027466
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7202
concepts[10].display_name	Molecular biology
concepts[11].id	https://openalex.org/C203014093
concepts[11].level	1
concepts[11].score	0.3541531562805176
concepts[11].wikidata	https://www.wikidata.org/wiki/Q101929
concepts[11].display_name	Immunology
concepts[12].id	https://openalex.org/C502942594
concepts[12].level	1
concepts[12].score	0.332908034324646
concepts[12].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[12].display_name	Cancer research
concepts[13].id	https://openalex.org/C95444343
concepts[13].level	1
concepts[13].score	0.32544875144958496
concepts[13].wikidata	https://www.wikidata.org/wiki/Q7141
concepts[13].display_name	Cell biology
concepts[14].id	https://openalex.org/C111337013
concepts[14].level	2
concepts[14].score	0.32247620820999146
concepts[14].wikidata	https://www.wikidata.org/wiki/Q2737837
concepts[14].display_name	Irradiation
concepts[15].id	https://openalex.org/C150194340
concepts[15].level	3
concepts[15].score	0.30731743574142456
concepts[15].wikidata	https://www.wikidata.org/wiki/Q26972
concepts[15].display_name	Gene expression
concepts[16].id	https://openalex.org/C104317684
concepts[16].level	2
concepts[16].score	0.27774113416671753
concepts[16].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[16].display_name	Gene
concepts[17].id	https://openalex.org/C8891405
concepts[17].level	2
concepts[17].score	0.2620185911655426
concepts[17].wikidata	https://www.wikidata.org/wiki/Q1059
concepts[17].display_name	Immune system
concepts[18].id	https://openalex.org/C71924100
concepts[18].level	0
concepts[18].score	0.2146260142326355
concepts[18].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[18].display_name	Medicine
concepts[19].id	https://openalex.org/C55493867
concepts[19].level	1
concepts[19].score	0.17192605137825012
concepts[19].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[19].display_name	Biochemistry
concepts[20].id	https://openalex.org/C181199279
concepts[20].level	2
concepts[20].score	0.08912593126296997
concepts[20].wikidata	https://www.wikidata.org/wiki/Q8047
concepts[20].display_name	Enzyme
concepts[21].id	https://openalex.org/C121332964
concepts[21].level	0
concepts[21].score	0.0
concepts[21].wikidata	https://www.wikidata.org/wiki/Q413
concepts[21].display_name	Physics
concepts[22].id	https://openalex.org/C185544564
concepts[22].level	1
concepts[22].score	0.0
concepts[22].wikidata	https://www.wikidata.org/wiki/Q81197
concepts[22].display_name	Nuclear physics
concepts[23].id	https://openalex.org/C99454951
concepts[23].level	1
concepts[23].score	0.0
concepts[23].wikidata	https://www.wikidata.org/wiki/Q932068
concepts[23].display_name	Environmental health
keywords[0].id	https://openalex.org/keywords/transcriptome
keywords[0].score	0.6018326282501221
keywords[0].display_name	Transcriptome
keywords[1].id	https://openalex.org/keywords/spermidine
keywords[1].score	0.5948822498321533
keywords[1].display_name	Spermidine
keywords[2].id	https://openalex.org/keywords/downregulation-and-upregulation
keywords[2].score	0.5912579894065857
keywords[2].display_name	Downregulation and upregulation
keywords[3].id	https://openalex.org/keywords/cd8
keywords[3].score	0.5817707180976868
keywords[3].display_name	CD8
keywords[4].id	https://openalex.org/keywords/biology
keywords[4].score	0.5095767974853516
keywords[4].display_name	Biology
keywords[5].id	https://openalex.org/keywords/ionizing-radiation
keywords[5].score	0.4667969346046448
keywords[5].display_name	Ionizing radiation
keywords[6].id	https://openalex.org/keywords/andrology
keywords[6].score	0.45991790294647217
keywords[6].display_name	Andrology
keywords[7].id	https://openalex.org/keywords/inflammation
keywords[7].score	0.44906890392303467
keywords[7].display_name	Inflammation
keywords[8].id	https://openalex.org/keywords/cell
keywords[8].score	0.44783735275268555
keywords[8].display_name	Cell
keywords[9].id	https://openalex.org/keywords/population
keywords[9].score	0.4218023121356964
keywords[9].display_name	Population
keywords[10].id	https://openalex.org/keywords/molecular-biology
keywords[10].score	0.3700915575027466
keywords[10].display_name	Molecular biology
keywords[11].id	https://openalex.org/keywords/immunology
keywords[11].score	0.3541531562805176
keywords[11].display_name	Immunology
keywords[12].id	https://openalex.org/keywords/cancer-research
keywords[12].score	0.332908034324646
keywords[12].display_name	Cancer research
keywords[13].id	https://openalex.org/keywords/cell-biology
keywords[13].score	0.32544875144958496
keywords[13].display_name	Cell biology
keywords[14].id	https://openalex.org/keywords/irradiation
keywords[14].score	0.32247620820999146
keywords[14].display_name	Irradiation
keywords[15].id	https://openalex.org/keywords/gene-expression
keywords[15].score	0.30731743574142456
keywords[15].display_name	Gene expression
keywords[16].id	https://openalex.org/keywords/gene
keywords[16].score	0.27774113416671753
keywords[16].display_name	Gene
keywords[17].id	https://openalex.org/keywords/immune-system
keywords[17].score	0.2620185911655426
keywords[17].display_name	Immune system
keywords[18].id	https://openalex.org/keywords/medicine
keywords[18].score	0.2146260142326355
keywords[18].display_name	Medicine
keywords[19].id	https://openalex.org/keywords/biochemistry
keywords[19].score	0.17192605137825012
keywords[19].display_name	Biochemistry
keywords[20].id	https://openalex.org/keywords/enzyme
keywords[20].score	0.08912593126296997
keywords[20].display_name	Enzyme
language	en
locations[0].id	doi:10.1016/j.exger.2024.112646
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S122591147
locations[0].source.issn	0531-5565, 1873-6815
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	0531-5565
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	Experimental Gerontology
locations[0].source.host_organization	https://openalex.org/P4310320990
locations[0].source.host_organization_name	Elsevier BV
locations[0].source.host_organization_lineage	https://openalex.org/P4310320990
locations[0].license
locations[0].pdf_url
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Experimental Gerontology
locations[0].landing_page_url	https://doi.org/10.1016/j.exger.2024.112646
locations[1].id	pmid:39643253
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Experimental gerontology
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/39643253
locations[2].id	pmh:oai:osti.gov:2496801
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306402487
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
locations[2].source.host_organization	https://openalex.org/I139351228
locations[2].source.host_organization_name	Office of Scientific and Technical Information
locations[2].source.host_organization_lineage	https://openalex.org/I139351228
locations[2].license
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type
locations[2].license_id
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name
locations[2].landing_page_url	https://www.osti.gov/biblio/2496801
locations[3].id	pmh:oai:doaj.org/article:2544aa00f946441e8ddd7b311d20dc46
locations[3].is_oa	False
locations[3].source.id	https://openalex.org/S4306401280
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	DOAJ (DOAJ: Directory of Open Access Journals)
locations[3].source.host_organization
locations[3].source.host_organization_name
locations[3].source.host_organization_lineage
locations[3].license
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	article
locations[3].license_id
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name	Experimental Gerontology, Vol 199, Iss , Pp 112646- (2025)
locations[3].landing_page_url	https://doaj.org/article/2544aa00f946441e8ddd7b311d20dc46
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5038305941
authorships[0].author.orcid	https://orcid.org/0000-0003-2516-8814
authorships[0].author.display_name	Kengo Yoshida
authorships[0].countries	JP
authorships[0].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[0].affiliations[0].raw_affiliation_string	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan. Electronic address: [email protected].
authorships[0].institutions[0].id	https://openalex.org/I21578748
authorships[0].institutions[0].ror	https://ror.org/01fmtas32
authorships[0].institutions[0].type	facility
authorships[0].institutions[0].lineage	https://openalex.org/I21578748
authorships[0].institutions[0].country_code	JP
authorships[0].institutions[0].display_name	Radiation Effects Research Foundation
authorships[0].author_position	first
authorships[0].raw_author_name	Kengo Yoshida
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan. Electronic address: [email protected].
authorships[1].author.id	https://openalex.org/A5101443663
authorships[1].author.orcid	https://orcid.org/0000-0003-3052-9151
authorships[1].author.display_name	Zhenqiu Liu
authorships[1].countries	JP
authorships[1].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[1].affiliations[0].raw_affiliation_string	Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[1].institutions[0].id	https://openalex.org/I21578748
authorships[1].institutions[0].ror	https://ror.org/01fmtas32
authorships[1].institutions[0].type	facility
authorships[1].institutions[0].lineage	https://openalex.org/I21578748
authorships[1].institutions[0].country_code	JP
authorships[1].institutions[0].display_name	Radiation Effects Research Foundation
authorships[1].author_position	middle
authorships[1].raw_author_name	Zhenqiu Liu
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[2].author.id	https://openalex.org/A5103070895
authorships[2].author.orcid	https://orcid.org/0000-0002-2807-9609
authorships[2].author.display_name	Yoshiko Kubo
authorships[2].countries	JP
authorships[2].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[2].affiliations[0].raw_affiliation_string	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[2].institutions[0].id	https://openalex.org/I21578748
authorships[2].institutions[0].ror	https://ror.org/01fmtas32
authorships[2].institutions[0].type	facility
authorships[2].institutions[0].lineage	https://openalex.org/I21578748
authorships[2].institutions[0].country_code	JP
authorships[2].institutions[0].display_name	Radiation Effects Research Foundation
authorships[2].author_position	middle
authorships[2].raw_author_name	Yoshiko Kubo
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[3].author.id	https://openalex.org/A5089552764
authorships[3].author.orcid
authorships[3].author.display_name	Masahiko Miura
authorships[3].countries	JP
authorships[3].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[3].affiliations[0].raw_affiliation_string	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[3].institutions[0].id	https://openalex.org/I21578748
authorships[3].institutions[0].ror	https://ror.org/01fmtas32
authorships[3].institutions[0].type	facility
authorships[3].institutions[0].lineage	https://openalex.org/I21578748
authorships[3].institutions[0].country_code	JP
authorships[3].institutions[0].display_name	Radiation Effects Research Foundation
authorships[3].author_position	middle
authorships[3].raw_author_name	Masahiko Miura
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[4].author.id	https://openalex.org/A5113574036
authorships[4].author.orcid
authorships[4].author.display_name	Mika Yamaoka
authorships[4].countries	JP
authorships[4].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[4].affiliations[0].raw_affiliation_string	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[4].institutions[0].id	https://openalex.org/I21578748
authorships[4].institutions[0].ror	https://ror.org/01fmtas32
authorships[4].institutions[0].type	facility
authorships[4].institutions[0].lineage	https://openalex.org/I21578748
authorships[4].institutions[0].country_code	JP
authorships[4].institutions[0].display_name	Radiation Effects Research Foundation
authorships[4].author_position	middle
authorships[4].raw_author_name	Mika Yamaoka
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[5].author.id	https://openalex.org/A5022802516
authorships[5].author.orcid
authorships[5].author.display_name	Hiroko Nagamura
authorships[5].countries	JP
authorships[5].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[5].affiliations[0].raw_affiliation_string	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[5].institutions[0].id	https://openalex.org/I21578748
authorships[5].institutions[0].ror	https://ror.org/01fmtas32
authorships[5].institutions[0].type	facility
authorships[5].institutions[0].lineage	https://openalex.org/I21578748
authorships[5].institutions[0].country_code	JP
authorships[5].institutions[0].display_name	Radiation Effects Research Foundation
authorships[5].author_position	middle
authorships[5].raw_author_name	Hiroko Nagamura
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[6].author.id	https://openalex.org/A5035072883
authorships[6].author.orcid	https://orcid.org/0000-0003-2698-4880
authorships[6].author.display_name	Munechika Misumi
authorships[6].countries	JP
authorships[6].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[6].affiliations[0].raw_affiliation_string	Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[6].institutions[0].id	https://openalex.org/I21578748
authorships[6].institutions[0].ror	https://ror.org/01fmtas32
authorships[6].institutions[0].type	facility
authorships[6].institutions[0].lineage	https://openalex.org/I21578748
authorships[6].institutions[0].country_code	JP
authorships[6].institutions[0].display_name	Radiation Effects Research Foundation
authorships[6].author_position	middle
authorships[6].raw_author_name	Munechika Misumi
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[7].author.id	https://openalex.org/A5032310314
authorships[7].author.orcid
authorships[7].author.display_name	Yoichiro Kusunoki
authorships[7].countries	JP
authorships[7].affiliations[0].institution_ids	https://openalex.org/I21578748
authorships[7].affiliations[0].raw_affiliation_string	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
authorships[7].institutions[0].id	https://openalex.org/I21578748
authorships[7].institutions[0].ror	https://ror.org/01fmtas32
authorships[7].institutions[0].type	facility
authorships[7].institutions[0].lineage	https://openalex.org/I21578748
authorships[7].institutions[0].country_code	JP
authorships[7].institutions[0].display_name	Radiation Effects Research Foundation
authorships[7].author_position	last
authorships[7].raw_author_name	Yoichiro Kusunoki
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1016/j.exger.2024.112646
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T11924
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.9990000128746033
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	Polyamine Metabolism and Applications
related_works	https://openalex.org/W3122203336, https://openalex.org/W4367186029, https://openalex.org/W2113815141, https://openalex.org/W2070333523, https://openalex.org/W2061798496, https://openalex.org/W2378972344, https://openalex.org/W2033930123, https://openalex.org/W2096098657, https://openalex.org/W2402745654, https://openalex.org/W2018708511
cited_by_count	1
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	1
locations_count	4
best_oa_location.id	doi:10.1016/j.exger.2024.112646
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S122591147
best_oa_location.source.issn	0531-5565, 1873-6815
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	0531-5565
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	Experimental Gerontology
best_oa_location.source.host_organization	https://openalex.org/P4310320990
best_oa_location.source.host_organization_name	Elsevier BV
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310320990
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Experimental Gerontology
best_oa_location.landing_page_url	https://doi.org/10.1016/j.exger.2024.112646
primary_location.id	doi:10.1016/j.exger.2024.112646
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S122591147
primary_location.source.issn	0531-5565, 1873-6815
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	0531-5565
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	Experimental Gerontology
primary_location.source.host_organization	https://openalex.org/P4310320990
primary_location.source.host_organization_name	Elsevier BV
primary_location.source.host_organization_lineage	https://openalex.org/P4310320990
primary_location.license
primary_location.pdf_url
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Experimental Gerontology
primary_location.landing_page_url	https://doi.org/10.1016/j.exger.2024.112646
publication_date	2024-12-18
publication_year	2024
referenced_works	https://openalex.org/W4307441073, https://openalex.org/W3112391596, https://openalex.org/W6725972671, https://openalex.org/W3163538648, https://openalex.org/W2951912016, https://openalex.org/W3030573519, https://openalex.org/W3027187303, https://openalex.org/W2169456326, https://openalex.org/W2045611938, https://openalex.org/W2120076861, https://openalex.org/W4313405092, https://openalex.org/W4385564355, https://openalex.org/W2062238292, https://openalex.org/W4312181028, https://openalex.org/W2103589112, https://openalex.org/W2179438025, https://openalex.org/W2784734859, https://openalex.org/W3160268512, https://openalex.org/W2592811885, https://openalex.org/W2097821680, https://openalex.org/W2613309479, https://openalex.org/W4294671500, https://openalex.org/W4211096034, https://openalex.org/W1600190664, https://openalex.org/W2519214071, https://openalex.org/W6858401481, https://openalex.org/W2515340741, https://openalex.org/W3130705013, https://openalex.org/W2928665623, https://openalex.org/W4388850736
referenced_works_count	30
abstract_inverted_index
cited_by_percentile_year.max	95
cited_by_percentile_year.min	91
countries_distinct_count	1
institutions_distinct_count	8
citation_normalized_percentile.value	0.63717562
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False