bioRxiv (Cold Spring Harbor Laboratory)
SPEX: A modular end-to-end platform for high-plex tissue spatial omics analysis
August 2022 • Xiaoli Li, Ximo Pechuan-Jorge, Tyler Risom, Conrad Foo, A. Ya. Prilipko, Artem Zubkov, Caleb Chan, Patrick Chang, Frank Peale, James Ziai, Sandra Ros…
ABSTRACT Recent advancements in transcriptomics and proteomics have opened the possibility for spatially resolved molecular characterization of tissue architecture with the promise of enabling a deeper understanding of tissue biology in either homeostasis or disease. The wealth of data generated by these technologies has recently driven the development of a wide range of computational methods. These methods have the requirement of advanced coding fluency to be applied and integrated across the full spatial omics a…