Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in Hepatitis C Virus RNA Replication Factories Article Swipe
Hossam Gewaid
,
Haruyo Aoyagi
,
Minetaro Arita
,
Koichi Watashi
,
Ryosuke Suzuki
,
Shota Sakai
,
Keigo Kumagai
,
Toshiyuki Yamaji
,
Masayoshi Fukasawa
,
Fumihiro Kato
,
Takayuki Hishiki
,
Ayako Mimata
,
Yuriko Sakamaki
,
Shizuko Ichinose
,
Kentaro Hanada
,
Masamichi Muramatsu
,
Takaji Wakita
,
Hideki Aizaki
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1128/jvi.01080-20
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1128/jvi.01080-20
Previous reports assumed that sphingomyelin (SM) is essential for HCV replication, but the mechanism was unclear. In this study, we showed for the first time that SM and ceramide transfer protein (CERT), which is in the SM biosynthesis pathway, are essential for the biosynthesis of double-membrane vesicles (DMVs), the sites of viral replication. Low numbers of DMVs were observed in CERT-KO cells transfected with replicon RNA or with constructs that drive HCV protein production in a replication-independent system. HCV replication was rescued by ectopic expression of the CERT protein, but not by CERT mutants, that abolishes the binding of CERT to vesicle-associated membrane protein-associated protein (VAP) or phosphatidylinositol 4-phosphate (PI4P), indicating new roles for VAP and PI4P in HCV replication. The biosynthesis of DMVs has great importance to replication by a variety of plus-stranded RNA viruses. Understanding of this process is expected to facilitate the development of diagnosis and antivirus.
Related Topics
Concepts
Biology
Replicon
Cell biology
Viral replication
Replication factor C
RNA
RNA-dependent RNA polymerase
Virology
Virus
Control of chromosome duplication
Biochemistry
Gene
DNA replication
Genome
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/jvi.01080-20
- OA Status
- green
- Cited By
- 38
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3086058250
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3086058250Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1128/jvi.01080-20Digital Object Identifier
- Title
-
Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in Hepatitis C Virus RNA Replication FactoriesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-09-11Full publication date if available
- Authors
-
Hossam Gewaid, Haruyo Aoyagi, Minetaro Arita, Koichi Watashi, Ryosuke Suzuki, Shota Sakai, Keigo Kumagai, Toshiyuki Yamaji, Masayoshi Fukasawa, Fumihiro Kato, Takayuki Hishiki, Ayako Mimata, Yuriko Sakamaki, Shizuko Ichinose, Kentaro Hanada, Masamichi Muramatsu, Takaji Wakita, Hideki AizakiList of authors in order
- Landing page
-
https://doi.org/10.1128/jvi.01080-20Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/7654263Direct OA link when available
- Concepts
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Biology, Replicon, Cell biology, Viral replication, Replication factor C, RNA, RNA-dependent RNA polymerase, Virology, Virus, Control of chromosome duplication, Biochemistry, Gene, DNA replication, GenomeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
38Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 13, 2023: 5, 2022: 11, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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