PubMed • Vol 135 • No 6
Spinal Anesthesia with Targeted Sedation based on Bispectral Index Values Compared with General Anesthesia with Masked Bispectral Index Values to Reduce Delirium: The SHARP Randomized Controlled Trial.
December 2021 • Charles H. Brown, Charles C. Edwards, Charles Y. Lin, Emily Jones, Lisa R. Yanek, Melody Esmaili, Yara Gorashi, Richard Skelton, Daniel Kaganov, Ryan…
BACKGROUND: Reducing depth of anesthesia and anesthetic exposure may help prevent delirium, but trials have been conflicting. Most studies were conducted under general anesthesia or in cognitively-impaired patients. It is unclear whether reducing depth of anesthesia beyond levels consistent with general anesthesia reduces delirium in cognitively-intact patients. Our objective was to determine whether a bundled approach to reduce anesthetic agent exposure as determined by BIS values (spinal anesthesia with targeted…