Spinal cord involvement and cardiovascular autonomic dysfunction in Parkinson’s disease Article Swipe
Lydia Chougar
,
François‐Xavier Lejeune
,
Julien Cohen‐Adad
,
Caroline Landelle
,
Mathieu Guay-Paquet
,
Joshua Newton
,
Jan Valošek
,
Emma Biondetti
,
Čarna Jovanović
,
Karl Wennberg
,
Alain Dagher
,
Julien Doyon
,
Nadya Pyatigorskaya
,
Sara Sambin
,
Graziella Mangone
,
Jean-Christophe Corvol
,
Isabelle Arnulf
,
Marie Vidailhet
,
Stéphane Lehéricy
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7704958/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7704958/v1
Background : Patients with Parkinson’s disease (PD) frequently present autonomic cardiovascular dysfunction. This study investigated the involvement of autonomic centers in the upper thoracic spinal cord in cardiovascular dysfunction in patients with PD using multimodal MRI and markers of orthostatic hypotension. Methods : We recruited 26 patients with PD, stratified based on the presence (PD RBD(+) , n=11) or absence (PD RBD(-) , n=15) of rapid-eye movement sleep behavior disorder (RBD), and 22 matched healthy controls (HC). Participants underwent multimodal MRI of the cervical and upper thoracic spinal cord. Quantitative metrics, including T1 relaxation times, diffusion metrics, and magnetization transfer ratio (MTR) values, were extracted from gray and white matter spinal cord regions. MRI metrics were compared across groups and examined for associations with blood pressure drops, both cross-sectionally and longitudinally, as indicators of orthostatic hypotension. Results : No significant differences in MRI metrics were found between patients with PD and HCs, nor between PD subgroups. A multivariate analysis pooling all MRI metrics together allowed for the separation of HCs and PD subgroups. In the PD RBD(+) subgroup, positive correlations were found between systolic blood pressure drop and T1 relaxation times as well as mean diffusivity values at the cervicothoracic junction. Longitudinal changes in blood pressure drops were associated with MRI measurements after adjusting for baseline blood pressure, age, and sex, suggesting that these metrics may serve as potential markers of future blood pressure changes. Conclusions : Spinal cord quantitative MRI measurements at the cervicothoracic junction may be associated with orthostatic hypotension and its progression over time in PD RBD(+) patients.
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- Type
- preprint
- Landing Page
- https://doi.org/10.21203/rs.3.rs-7704958/v1
- https://www.researchsquare.com/article/rs-7704958/latest.pdf
- OA Status
- gold
- References
- 32
- OpenAlex ID
- https://openalex.org/W4415686902
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4415686902Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-7704958/v1Digital Object Identifier
- Title
-
Spinal cord involvement and cardiovascular autonomic dysfunction in Parkinson’s diseaseWork title
- Type
-
preprintOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
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2025-10-30Full publication date if available
- Authors
-
Lydia Chougar, François‐Xavier Lejeune, Julien Cohen‐Adad, Caroline Landelle, Mathieu Guay-Paquet, Joshua Newton, Jan Valošek, Emma Biondetti, Čarna Jovanović, Karl Wennberg, Alain Dagher, Julien Doyon, Nadya Pyatigorskaya, Sara Sambin, Graziella Mangone, Jean-Christophe Corvol, Isabelle Arnulf, Marie Vidailhet, Stéphane LehéricyList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-7704958/v1Publisher landing page
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https://www.researchsquare.com/article/rs-7704958/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-7704958/latest.pdfDirect OA link when available
- Cited by
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0Total citation count in OpenAlex
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32Number of works referenced by this work
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| abstract_inverted_index.separation | 168 |
| abstract_inverted_index.stratified | 50 |
| abstract_inverted_index.subgroups. | 156, 173 |
| abstract_inverted_index.suggesting | 222 |
| abstract_inverted_index.differences | 141 |
| abstract_inverted_index.diffusivity | 196 |
| abstract_inverted_index.dysfunction | 29 |
| abstract_inverted_index.hypotension | 252 |
| abstract_inverted_index.involvement | 17 |
| abstract_inverted_index.orthostatic | 40, 135, 251 |
| abstract_inverted_index.progression | 255 |
| abstract_inverted_index.significant | 140 |
| abstract_inverted_index.Longitudinal | 202 |
| abstract_inverted_index.Participants | 78 |
| abstract_inverted_index.Quantitative | 90 |
| abstract_inverted_index.associations | 123 |
| abstract_inverted_index.correlations | 180 |
| abstract_inverted_index.dysfunction. | 12 |
| abstract_inverted_index.hypotension. | 41, 136 |
| abstract_inverted_index.investigated | 15 |
| abstract_inverted_index.measurements | 212, 242 |
| abstract_inverted_index.multivariate | 158 |
| abstract_inverted_index.quantitative | 240 |
| abstract_inverted_index.Parkinson’s | 5 |
| abstract_inverted_index.magnetization | 99 |
| abstract_inverted_index.cardiovascular | 11, 28 |
| abstract_inverted_index.cervicothoracic | 200, 245 |
| abstract_inverted_index.longitudinally, | 131 |
| abstract_inverted_index.<sub>RBD(+)</sub> | 56, 177, 260 |
| abstract_inverted_index.<sub>RBD(-)</sub> | 62 |
| abstract_inverted_index.cross-sectionally | 129 |
| abstract_inverted_index.<bold>Methods</bold> | 42 |
| abstract_inverted_index.<bold>Results</bold> | 137 |
| abstract_inverted_index.<bold>Background</bold> | 1 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| abstract_inverted_index.<bold>Conclusions</bold> | 236 |
| cited_by_percentile_year | |
| countries_distinct_count | 3 |
| institutions_distinct_count | 19 |
| citation_normalized_percentile |