Splanchnic nerve modulation in heart failure: mechanistic overview, initial clinical experience, and safety considerations Article Swipe
Marat Fudim
,
Piotr Ponikowski
,
Daniel Burkhoff
,
Mark E. Dunlap
,
Paul A. Sobotka
,
Jeroen Molinger
,
Manesh R. Patel
,
G. Michael Felker
,
Adrian F. Hernandez
,
Sheldon E. Litwin
,
Barry A. Borlaug
,
Anisha Bapna
,
Horst Sievert
,
Vivek Y. Reddy
,
Zoar J. Engelman
,
Sanjiv J. Shah
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/ejhf.2196
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/ejhf.2196
Volume recruitment from the splanchnic compartment is an important physiological response to stressors such as physical activity and blood loss. In the setting of heart failure (HF), excess fluid redistribution from this compartment leads to increased cardiac filling pressures with limitation in exercise capacity. Recent evidence suggests that blocking neural activity of the greater splanchnic nerve (GSN) could have significant benefits in some patients with HF by reducing cardiac filling pressures and improving exercise capacity. However, to date the long‐term safety of splanchnic nerve modulation (SNM) in the setting of HF is unknown. SNM is currently used in clinical practice to alleviate some forms of chronic abdominal pain. A systematic review of the series where permanent SNM was used as a treatment for chronic abdominal pain indicates that permanent SNM is well tolerated, with side‐effects limited to transient diarrhoea or abdominal colic and transient hypotension. The pathophysiological role of the GSN in volume redistribution, the encouraging findings of acute and chronic pilot SNM studies and the safety profile from permanent SNM for pain provides a strong basis for continued efforts to study this therapeutic target in HF.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/ejhf.2196
- OA Status
- hybrid
- Cited By
- 50
- References
- 68
- Related Works
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- OpenAlex ID
- https://openalex.org/W3156635458
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3156635458Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/ejhf.2196Digital Object Identifier
- Title
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Splanchnic nerve modulation in heart failure: mechanistic overview, initial clinical experience, and safety considerationsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-22Full publication date if available
- Authors
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Marat Fudim, Piotr Ponikowski, Daniel Burkhoff, Mark E. Dunlap, Paul A. Sobotka, Jeroen Molinger, Manesh R. Patel, G. Michael Felker, Adrian F. Hernandez, Sheldon E. Litwin, Barry A. Borlaug, Anisha Bapna, Horst Sievert, Vivek Y. Reddy, Zoar J. Engelman, Sanjiv J. ShahList of authors in order
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https://doi.org/10.1002/ejhf.2196Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/ejhf.2196Direct OA link when available
- Concepts
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Medicine, Splanchnic, Heart failure, Anesthesia, Cardiology, Intensive care medicine, Internal medicine, HemodynamicsTop concepts (fields/topics) attached by OpenAlex
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50Total citation count in OpenAlex
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2025: 6, 2024: 10, 2023: 15, 2022: 15, 2021: 4Per-year citation counts (last 5 years)
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68Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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