Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival Article Swipe
Thi Viet Trinh Dang
,
Kevin R. Gillinder
,
Quan Nguyen
,
Onkar Mulay
,
Tuan Vo
,
Ahmed M. Mehdi
,
Chenhao Zhou
,
Andrew J. Brooks
,
Graham R. Leggatt
,
David Hume
,
Ian H. Frazer
,
Janin Chandra
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/cti2.70018
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/cti2.70018
Objectives Langerhans cells (LCs) are epithelial antigen‐presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechanisms of alteration of IL34 and LC function in squamous cell carcinoma (SCC). Methods Cancer cohort data were used to identify associations between SCC and IL34. ATAC‐seq of keratinocytes (KCs) and LCs from a murine model of epithelial hyperplasia, driven by HPV16 E7 oncoprotein (K14E7), was analysed. Transcriptomic data were used to validate findings. RNAscope, RT‐qPCR, ELISA and confocal imaging was used to analyse IL34 expression and LCs in a spatial context. Results IL34 mRNA is downregulated in human SCCs of the head and neck, the cervix, the lung and the oesophagus, and low IL34 expression is associated with poor survival. We demonstrate that KCs of K14E7 mice have reduced Il34 gene accessibility, mRNA and protein, as well as broad changes in promotor accessibility associated with cell adhesion and immune responses. Chromatin accessibility was substantially changed in LCs, including increased accessibility of the Csf1r gene, and changes in promotors associated with cytoskeleton arrangement and antigen processing and presentation. We discovered altered spatial LC dendrite organisation in hyperproliferative epithelium. Conclusion Squamous cell carcinoma of the cervix, head and neck, oesophagus and lung demonstrate downregulation of IL34, which is associated with poor survival, and with alterations in LC spatial organisation and function. These findings suggest that reduced IL34 expression in SCC may contribute to impaired local immunity through LC dysregulation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cti2.70018
- OA Status
- gold
- Cited By
- 2
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404861913
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404861913Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/cti2.70018Digital Object Identifier
- Title
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Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survivalWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-01-01Full publication date if available
- Authors
-
Thi Viet Trinh Dang, Kevin R. Gillinder, Quan Nguyen, Onkar Mulay, Tuan Vo, Ahmed M. Mehdi, Chenhao Zhou, Andrew J. Brooks, Graham R. Leggatt, David Hume, Ian H. Frazer, Janin ChandraList of authors in order
- Landing page
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https://doi.org/10.1002/cti2.70018Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1002/cti2.70018Direct OA link when available
- Concepts
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Biology, Antigen, Context (archaeology), Antigen presentation, Immune system, Cancer research, Downregulation and upregulation, Langerhans cell, Pathology, Immunology, Medicine, T cell, Gene, Biochemistry, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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68Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.production | 20 |
| abstract_inverted_index.responses. | 159 |
| abstract_inverted_index.alterations | 222 |
| abstract_inverted_index.arrangement | 181 |
| abstract_inverted_index.demonstrate | 131, 210 |
| abstract_inverted_index.epithelium. | 196 |
| abstract_inverted_index.interleukin | 17 |
| abstract_inverted_index.oesophagus, | 120 |
| abstract_inverted_index.oncoprotein | 72 |
| abstract_inverted_index.associations | 50 |
| abstract_inverted_index.contributing | 10 |
| abstract_inverted_index.cytoskeleton | 180 |
| abstract_inverted_index.hyperplasia, | 67 |
| abstract_inverted_index.organisation | 193, 226 |
| abstract_inverted_index.accessibility | 152, 161, 169 |
| abstract_inverted_index.downregulated | 105 |
| abstract_inverted_index.keratinocytes | 57 |
| abstract_inverted_index.presentation. | 186 |
| abstract_inverted_index.substantially | 163 |
| abstract_inverted_index.surveillance. | 13 |
| abstract_inverted_index.Transcriptomic | 76 |
| abstract_inverted_index.accessibility, | 141 |
| abstract_inverted_index.downregulation | 211 |
| abstract_inverted_index.dysregulation. | 246 |
| abstract_inverted_index.hyperproliferative | 195 |
| abstract_inverted_index.antigen‐presenting | 7 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.6700000166893005 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.71562488 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |