Clinical & Translational Immunology • Vol 13 • No 12
Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival
January 2024 • Thi Viet Trinh Dang, Kevin R. Gillinder, Quan Nguyen, Onkar Mulay, Tuan Vo, Ahmed M. Mehdi, Chenhao Zhou, Andrew J. Brooks, Graham R. Leggatt, David …
Abstract Objectives Langerhans cells (LCs) are epithelial antigen‐presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechanisms of alteration of IL34 and LC function in squamous cell carcinoma (SCC). Methods Cancer cohort data were used to identify associations between SCC and IL34. ATAC‐seq of keratinocytes (KCs) and LCs from a murine model of epithelial hyperplasia, driven by HPV16 E7 oncoprotein (K14E7), was…