Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 Article Swipe
Elodie De Bruyckere
,
Ruth Simon
,
Sigrun Nestel
,
Bernd Heimrich
,
Dennis Kätzel
,
Alexei V. Egorov
,
Pentao Liu
,
Nancy A. Jenkins
,
Neal G. Copeland
,
Herbert Schwegler
,
Andreas Draguhn
,
Stefan Britsch
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fnmol.2018.00103
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fnmol.2018.00103
Structural and functional plasticity of synapses are critical neuronal mechanisms underlying learning and memory. While activity-dependent regulation of synaptic strength has been extensively studied, much less is known about the transcriptional control of synapse maintenance and plasticity. Hippocampal mossy fiber (MF) synapses connect dentate granule cells to CA3 pyramidal neurons and are important for spatial memory formation and consolidation. The transcription factor Bcl11b/Ctip2 is expressed in dentate granule cells and required for postnatal hippocampal development. Ablation of Bcl11b/Ctip2 in the adult hippocampus results in impaired adult neurogenesis and spatial memory. The molecular mechanisms underlying the behavioral impairment remained unclear. Here we show that selective deletion of Bcl11b/Ctip2 in the adult mouse hippocampus leads to a rapid loss of excitatory synapses in CA3 as well as reduced ultrastructural complexity of remaining mossy fiber boutons (MFBs). Moreover, a dramatic decline of long-term potentiation (LTP) of the dentate gyrus-CA3 (DG-CA3) projection is caused by adult loss of Bcl11b/Ctip2. Differential transcriptomics revealed the deregulation of genes associated with synaptic transmission in mutants. Together, our data suggest Bcl11b/Ctip2 to regulate maintenance and function of MF synapses in the adult hippocampus.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnmol.2018.00103
- OA Status
- gold
- Cited By
- 28
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2795531881
All OpenAlex metadata
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https://openalex.org/W2795531881Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnmol.2018.00103Digital Object Identifier
- Title
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Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
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2018-04-05Full publication date if available
- Authors
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Elodie De Bruyckere, Ruth Simon, Sigrun Nestel, Bernd Heimrich, Dennis Kätzel, Alexei V. Egorov, Pentao Liu, Nancy A. Jenkins, Neal G. Copeland, Herbert Schwegler, Andreas Draguhn, Stefan BritschList of authors in order
- Landing page
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https://doi.org/10.3389/fnmol.2018.00103Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fnmol.2018.00103Direct OA link when available
- Concepts
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Mossy fiber (hippocampus), Neuroscience, Hippocampal formation, Biology, Dentate gyrusTop concepts (fields/topics) attached by OpenAlex
- Cited by
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28Total citation count in OpenAlex
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2025: 2, 2024: 8, 2023: 9, 2022: 5, 2021: 1Per-year citation counts (last 5 years)
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62Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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