Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate Article Swipe
Diana C. Rodriguez Camargo
,
Kyle J. Korshavn
,
Alexander Jussupow
,
Kolio Raltchev
,
David Goričanec
,
Markus C. Fleisch
,
Riddhiman Sarkar
,
Kai Xue
,
Michaela Aichler
,
Gabriele Mettenleiter
,
Axel Walch
,
Carlo Camilloni
,
Franz Hagn
,
Bernd Reif
,
Ayyalusamy Ramamoorthy
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.7554/elife.31226
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.7554/elife.31226
Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous insights into the pathology and aid in the design of compounds to potentially treat the diseases, it has not been feasible to overcome the challenges posed by the cell membrane. Here, we use NMR experimental constraints to solve the structure of a type-2 diabetes related human islet amyloid polypeptide intermediate stabilized in nanodiscs. ROSETTA and MD simulations resulted in a unique β-strand structure distinct from the conventional amyloid β-hairpin and revealed that the nucleating NFGAIL region remains flexible and accessible within this isolated intermediate, suggesting a mechanism by which membrane-associated aggregation may be propagated. The ability of nanodiscs to trap amyloid intermediates as demonstrated could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.31226
- OA Status
- gold
- Cited By
- 83
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2769200054
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2769200054Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.31226Digital Object Identifier
- Title
-
Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediateWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-11-17Full publication date if available
- Authors
-
Diana C. Rodriguez Camargo, Kyle J. Korshavn, Alexander Jussupow, Kolio Raltchev, David Goričanec, Markus C. Fleisch, Riddhiman Sarkar, Kai Xue, Michaela Aichler, Gabriele Mettenleiter, Axel Walch, Carlo Camilloni, Franz Hagn, Bernd Reif, Ayyalusamy RamamoorthyList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.31226Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.31226Direct OA link when available
- Concepts
-
Amyloid (mycology), Membrane, Biophysics, Chemistry, Islet, Cell membrane, Membrane protein, Cell biology, Biochemistry, Biology, Diabetes mellitus, Endocrinology, Inorganic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
83Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 5, 2023: 6, 2022: 10, 2021: 13Per-year citation counts (last 5 years)
- References (count)
-
64Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2769200054 |
|---|---|
| doi | https://doi.org/10.7554/elife.31226 |
| ids.doi | https://doi.org/10.7554/elife.31226 |
| ids.mag | 2769200054 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/29148426 |
| ids.openalex | https://openalex.org/W2769200054 |
| fwci | 7.9266755 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D058228 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | Islet Amyloid Polypeptide |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D058228 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Islet Amyloid Polypeptide |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D009682 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[4].qualifier_ui | Q000737 |
| mesh[4].descriptor_ui | D008566 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | chemistry |
| mesh[4].descriptor_name | Membranes |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D066329 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Protein Aggregates |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D017510 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Protein Folding |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D055503 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Protein Multimerization |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | Q000737 |
| mesh[9].descriptor_ui | D058228 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | chemistry |
| mesh[9].descriptor_name | Islet Amyloid Polypeptide |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D058228 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Islet Amyloid Polypeptide |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D009682 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[12].qualifier_ui | Q000737 |
| mesh[12].descriptor_ui | D008566 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | chemistry |
| mesh[12].descriptor_name | Membranes |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D066329 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Protein Aggregates |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D017510 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Protein Folding |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D055503 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Protein Multimerization |
| type | article |
| title | Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate |
| awards[0].id | https://openalex.org/G8543126164 |
| awards[0].funder_id | https://openalex.org/F4320332161 |
| awards[0].funder_award_id | AG048934 |
| awards[0].funder_display_name | National Institutes of Health |
| biblio.issue | |
| biblio.volume | 6 |
| biblio.last_page | |
| biblio.first_page | |
| grants[0].funder | https://openalex.org/F4320332161 |
| grants[0].award_id | AG048934 |
| grants[0].funder_display_name | National Institutes of Health |
| topics[0].id | https://openalex.org/T10086 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2737 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Alzheimer's disease research and treatments |
| topics[1].id | https://openalex.org/T10044 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9990000128746033 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Protein Structure and Dynamics |
| topics[2].id | https://openalex.org/T11150 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9958999752998352 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1307 |
| topics[2].subfield.display_name | Cell Biology |
| topics[2].display_name | Endoplasmic Reticulum Stress and Disease |
| funders[0].id | https://openalex.org/F4320332161 |
| funders[0].ror | https://ror.org/01cwqze88 |
| funders[0].display_name | National Institutes of Health |
| is_xpac | False |
| apc_list.value | 3000 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 3000 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2500 |
| concepts[0].id | https://openalex.org/C2777633098 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7984899878501892 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2736051 |
| concepts[0].display_name | Amyloid (mycology) |
| concepts[1].id | https://openalex.org/C41625074 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5899689793586731 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q176088 |
| concepts[1].display_name | Membrane |
| concepts[2].id | https://openalex.org/C12554922 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5473265647888184 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[2].display_name | Biophysics |
| concepts[3].id | https://openalex.org/C185592680 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5447155237197876 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[3].display_name | Chemistry |
| concepts[4].id | https://openalex.org/C165220095 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5382006764411926 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q207524 |
| concepts[4].display_name | Islet |
| concepts[5].id | https://openalex.org/C2778106830 |
| concepts[5].level | 3 |
| concepts[5].score | 0.44463682174682617 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q29548 |
| concepts[5].display_name | Cell membrane |
| concepts[6].id | https://openalex.org/C144647389 |
| concepts[6].level | 3 |
| concepts[6].score | 0.41273194551467896 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q423042 |
| concepts[6].display_name | Membrane protein |
| concepts[7].id | https://openalex.org/C95444343 |
| concepts[7].level | 1 |
| concepts[7].score | 0.38401687145233154 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[7].display_name | Cell biology |
| concepts[8].id | https://openalex.org/C55493867 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3394097089767456 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[8].display_name | Biochemistry |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.2813321352005005 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C555293320 |
| concepts[10].level | 2 |
| concepts[10].score | 0.06403714418411255 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12206 |
| concepts[10].display_name | Diabetes mellitus |
| concepts[11].id | https://openalex.org/C134018914 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[11].display_name | Endocrinology |
| concepts[12].id | https://openalex.org/C179104552 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11165 |
| concepts[12].display_name | Inorganic chemistry |
| keywords[0].id | https://openalex.org/keywords/amyloid |
| keywords[0].score | 0.7984899878501892 |
| keywords[0].display_name | Amyloid (mycology) |
| keywords[1].id | https://openalex.org/keywords/membrane |
| keywords[1].score | 0.5899689793586731 |
| keywords[1].display_name | Membrane |
| keywords[2].id | https://openalex.org/keywords/biophysics |
| keywords[2].score | 0.5473265647888184 |
| keywords[2].display_name | Biophysics |
| keywords[3].id | https://openalex.org/keywords/chemistry |
| keywords[3].score | 0.5447155237197876 |
| keywords[3].display_name | Chemistry |
| keywords[4].id | https://openalex.org/keywords/islet |
| keywords[4].score | 0.5382006764411926 |
| keywords[4].display_name | Islet |
| keywords[5].id | https://openalex.org/keywords/cell-membrane |
| keywords[5].score | 0.44463682174682617 |
| keywords[5].display_name | Cell membrane |
| keywords[6].id | https://openalex.org/keywords/membrane-protein |
| keywords[6].score | 0.41273194551467896 |
| keywords[6].display_name | Membrane protein |
| keywords[7].id | https://openalex.org/keywords/cell-biology |
| keywords[7].score | 0.38401687145233154 |
| keywords[7].display_name | Cell biology |
| keywords[8].id | https://openalex.org/keywords/biochemistry |
| keywords[8].score | 0.3394097089767456 |
| keywords[8].display_name | Biochemistry |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.2813321352005005 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/diabetes-mellitus |
| keywords[10].score | 0.06403714418411255 |
| keywords[10].display_name | Diabetes mellitus |
| language | en |
| locations[0].id | doi:10.7554/elife.31226 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S1336409049 |
| locations[0].source.issn | 2050-084X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2050-084X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | eLife |
| locations[0].source.host_organization | https://openalex.org/P4310311710 |
| locations[0].source.host_organization_name | eLife Sciences Publications Ltd |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311710 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | eLife |
| locations[0].landing_page_url | https://doi.org/10.7554/elife.31226 |
| locations[1].id | pmid:29148426 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | eLife |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/29148426 |
| locations[2].id | pmh:oai:doaj.org/article:83e9a3672fef478bbca4e26152d644a1 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | eLife, Vol 6 (2017) |
| locations[2].landing_page_url | https://doaj.org/article/83e9a3672fef478bbca4e26152d644a1 |
| locations[3].id | pmh:oai:air.unimi.it:2434/533806 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400516 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) |
| locations[3].source.host_organization | https://openalex.org/I189158943 |
| locations[3].source.host_organization_name | University of Milan |
| locations[3].source.host_organization_lineage | https://openalex.org/I189158943 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | info:eu-repo/semantics/article |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://hdl.handle.net/2434/533806 |
| locations[4].id | pmh:oai:mediatum.ub.tum.de:node/1439752 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400453 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) |
| locations[4].source.host_organization | https://openalex.org/I62916508 |
| locations[4].source.host_organization_name | Technical University of Munich |
| locations[4].source.host_organization_lineage | https://openalex.org/I62916508 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | http://mediatum.ub.tum.de/node?id=1439752 |
| locations[5].id | pmh:oai:pubmedcentral.nih.gov:5706959 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S2764455111 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | PubMed Central |
| locations[5].source.host_organization | https://openalex.org/I1299303238 |
| locations[5].source.host_organization_name | National Institutes of Health |
| locations[5].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Text |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | |
| locations[5].landing_page_url | http://doi.org/10.7554/eLife.31226 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5009771748 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-3522-4859 |
| authorships[0].author.display_name | Diana C. Rodriguez Camargo |
| authorships[0].countries | DE, US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210137766, https://openalex.org/I62916508 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I189554337, https://openalex.org/I62916508 |
| authorships[0].affiliations[1].raw_affiliation_string | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I27837315 |
| authorships[0].affiliations[2].raw_affiliation_string | Program in Biophysics, Department of Chemistry, University of Michigan, Ann Arbor, United States |
| authorships[0].institutions[0].id | https://openalex.org/I189554337 |
| authorships[0].institutions[0].ror | https://ror.org/032hzb643 |
| authorships[0].institutions[0].type | other |
| authorships[0].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I189554337, https://openalex.org/I62916508, https://openalex.org/I8204097 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Center for Integrated Protein Science Munich |
| authorships[0].institutions[1].id | https://openalex.org/I4210137766 |
| authorships[0].institutions[1].ror | https://ror.org/03xg85719 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210137766 |
| authorships[0].institutions[1].country_code | DE |
| authorships[0].institutions[1].display_name | Institute for Advanced Study |
| authorships[0].institutions[2].id | https://openalex.org/I62916508 |
| authorships[0].institutions[2].ror | https://ror.org/02kkvpp62 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I62916508 |
| authorships[0].institutions[2].country_code | DE |
| authorships[0].institutions[2].display_name | Technical University of Munich |
| authorships[0].institutions[3].id | https://openalex.org/I27837315 |
| authorships[0].institutions[3].ror | https://ror.org/00jmfr291 |
| authorships[0].institutions[3].type | education |
| authorships[0].institutions[3].lineage | https://openalex.org/I27837315 |
| authorships[0].institutions[3].country_code | US |
| authorships[0].institutions[3].display_name | University of Michigan |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Diana C Rodriguez Camargo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany, Institute for Advanced Study, Technische Universität München, Garching, Germany, Program in Biophysics, Department of Chemistry, University of Michigan, Ann Arbor, United States |
| authorships[1].author.id | https://openalex.org/A5032576632 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-2623-1838 |
| authorships[1].author.display_name | Kyle J. Korshavn |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[1].affiliations[0].raw_affiliation_string | Program in Biophysics, Department of Chemistry, University of Michigan, Ann Arbor, United States; |
| authorships[1].institutions[0].id | https://openalex.org/I27837315 |
| authorships[1].institutions[0].ror | https://ror.org/00jmfr291 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I27837315 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of Michigan |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Kyle J Korshavn |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Program in Biophysics, Department of Chemistry, University of Michigan, Ann Arbor, United States; |
| authorships[2].author.id | https://openalex.org/A5045312855 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-7851-2741 |
| authorships[2].author.display_name | Alexander Jussupow |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210137766, https://openalex.org/I62916508 |
| authorships[2].affiliations[0].raw_affiliation_string | Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[2].institutions[0].id | https://openalex.org/I4210137766 |
| authorships[2].institutions[0].ror | https://ror.org/03xg85719 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210137766 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | Institute for Advanced Study |
| authorships[2].institutions[1].id | https://openalex.org/I62916508 |
| authorships[2].institutions[1].ror | https://ror.org/02kkvpp62 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I62916508 |
| authorships[2].institutions[1].country_code | DE |
| authorships[2].institutions[1].display_name | Technical University of Munich |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Alexander Jussupow |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[3].author.id | https://openalex.org/A5049765558 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Kolio Raltchev |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I189554337, https://openalex.org/I62916508 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I189554337 |
| authorships[3].institutions[0].ror | https://ror.org/032hzb643 |
| authorships[3].institutions[0].type | other |
| authorships[3].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I189554337, https://openalex.org/I62916508, https://openalex.org/I8204097 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Center for Integrated Protein Science Munich |
| authorships[3].institutions[1].id | https://openalex.org/I62916508 |
| authorships[3].institutions[1].ror | https://ror.org/02kkvpp62 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I62916508 |
| authorships[3].institutions[1].country_code | DE |
| authorships[3].institutions[1].display_name | Technical University of Munich |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Kolio Raltchev |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[4].author.id | https://openalex.org/A5087892472 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | David Goričanec |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I189554337, https://openalex.org/I62916508 |
| authorships[4].affiliations[0].raw_affiliation_string | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[4].institutions[0].id | https://openalex.org/I189554337 |
| authorships[4].institutions[0].ror | https://ror.org/032hzb643 |
| authorships[4].institutions[0].type | other |
| authorships[4].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I189554337, https://openalex.org/I62916508, https://openalex.org/I8204097 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | Center for Integrated Protein Science Munich |
| authorships[4].institutions[1].id | https://openalex.org/I62916508 |
| authorships[4].institutions[1].ror | https://ror.org/02kkvpp62 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I62916508 |
| authorships[4].institutions[1].country_code | DE |
| authorships[4].institutions[1].display_name | Technical University of Munich |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | David Goricanec |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[5].author.id | https://openalex.org/A5061791206 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-8966-4721 |
| authorships[5].author.display_name | Markus C. Fleisch |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[5].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[5].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Markus Fleisch |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[6].author.id | https://openalex.org/A5043141980 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-9055-7897 |
| authorships[6].author.display_name | Riddhiman Sarkar |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I189554337, https://openalex.org/I62916508 |
| authorships[6].affiliations[0].raw_affiliation_string | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I189554337 |
| authorships[6].institutions[0].ror | https://ror.org/032hzb643 |
| authorships[6].institutions[0].type | other |
| authorships[6].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I189554337, https://openalex.org/I62916508, https://openalex.org/I8204097 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | Center for Integrated Protein Science Munich |
| authorships[6].institutions[1].id | https://openalex.org/I62916508 |
| authorships[6].institutions[1].ror | https://ror.org/02kkvpp62 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I62916508 |
| authorships[6].institutions[1].country_code | DE |
| authorships[6].institutions[1].display_name | Technical University of Munich |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Riddhiman Sarkar |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[7].author.id | https://openalex.org/A5101860282 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4210-6965 |
| authorships[7].author.display_name | Kai Xue |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[7].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[7].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Kai Xue |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[8].author.id | https://openalex.org/A5047570469 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Michaela Aichler |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[8].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[8].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[8].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Michaela Aichler |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[9].author.id | https://openalex.org/A5076452064 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Gabriele Mettenleiter |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[9].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[9].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[9].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Gabriele Mettenleiter |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[10].author.id | https://openalex.org/A5074211261 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-5578-4023 |
| authorships[10].author.display_name | Axel Walch |
| authorships[10].countries | DE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[10].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[10].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[10].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[10].institutions[0].type | facility |
| authorships[10].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[10].institutions[0].country_code | DE |
| authorships[10].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Axel Karl Walch |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[11].author.id | https://openalex.org/A5044583992 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-9923-8590 |
| authorships[11].author.display_name | Carlo Camilloni |
| authorships[11].countries | DE |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210137766, https://openalex.org/I62916508 |
| authorships[11].affiliations[0].raw_affiliation_string | Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[11].institutions[0].id | https://openalex.org/I4210137766 |
| authorships[11].institutions[0].ror | https://ror.org/03xg85719 |
| authorships[11].institutions[0].type | facility |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210137766 |
| authorships[11].institutions[0].country_code | DE |
| authorships[11].institutions[0].display_name | Institute for Advanced Study |
| authorships[11].institutions[1].id | https://openalex.org/I62916508 |
| authorships[11].institutions[1].ror | https://ror.org/02kkvpp62 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I62916508 |
| authorships[11].institutions[1].country_code | DE |
| authorships[11].institutions[1].display_name | Technical University of Munich |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Carlo Camilloni |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[12].author.id | https://openalex.org/A5015467573 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-1315-459X |
| authorships[12].author.display_name | Franz Hagn |
| authorships[12].countries | DE |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I189554337, https://openalex.org/I62916508 |
| authorships[12].affiliations[0].raw_affiliation_string | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I4210137766, https://openalex.org/I62916508 |
| authorships[12].affiliations[1].raw_affiliation_string | Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[12].affiliations[2].institution_ids | https://openalex.org/I3018134672 |
| authorships[12].affiliations[2].raw_affiliation_string | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[12].institutions[0].id | https://openalex.org/I189554337 |
| authorships[12].institutions[0].ror | https://ror.org/032hzb643 |
| authorships[12].institutions[0].type | other |
| authorships[12].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I189554337, https://openalex.org/I62916508, https://openalex.org/I8204097 |
| authorships[12].institutions[0].country_code | DE |
| authorships[12].institutions[0].display_name | Center for Integrated Protein Science Munich |
| authorships[12].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[12].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[12].institutions[1].type | facility |
| authorships[12].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[12].institutions[1].country_code | DE |
| authorships[12].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[12].institutions[2].id | https://openalex.org/I4210137766 |
| authorships[12].institutions[2].ror | https://ror.org/03xg85719 |
| authorships[12].institutions[2].type | facility |
| authorships[12].institutions[2].lineage | https://openalex.org/I4210137766 |
| authorships[12].institutions[2].country_code | DE |
| authorships[12].institutions[2].display_name | Institute for Advanced Study |
| authorships[12].institutions[3].id | https://openalex.org/I62916508 |
| authorships[12].institutions[3].ror | https://ror.org/02kkvpp62 |
| authorships[12].institutions[3].type | education |
| authorships[12].institutions[3].lineage | https://openalex.org/I62916508 |
| authorships[12].institutions[3].country_code | DE |
| authorships[12].institutions[3].display_name | Technical University of Munich |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Franz Hagn |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany, Helmholtz Zentrum München, Neuherberg, Germany, Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[13].author.id | https://openalex.org/A5040084490 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-7368-7198 |
| authorships[13].author.display_name | Bernd Reif |
| authorships[13].countries | DE |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I189554337, https://openalex.org/I62916508 |
| authorships[13].affiliations[0].raw_affiliation_string | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I3018134672 |
| authorships[13].affiliations[1].raw_affiliation_string | Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[13].institutions[0].id | https://openalex.org/I189554337 |
| authorships[13].institutions[0].ror | https://ror.org/032hzb643 |
| authorships[13].institutions[0].type | other |
| authorships[13].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I189554337, https://openalex.org/I62916508, https://openalex.org/I8204097 |
| authorships[13].institutions[0].country_code | DE |
| authorships[13].institutions[0].display_name | Center for Integrated Protein Science Munich |
| authorships[13].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[13].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[13].institutions[1].type | facility |
| authorships[13].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[13].institutions[1].country_code | DE |
| authorships[13].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[13].institutions[2].id | https://openalex.org/I62916508 |
| authorships[13].institutions[2].ror | https://ror.org/02kkvpp62 |
| authorships[13].institutions[2].type | education |
| authorships[13].institutions[2].lineage | https://openalex.org/I62916508 |
| authorships[13].institutions[2].country_code | DE |
| authorships[13].institutions[2].display_name | Technical University of Munich |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Bernd Reif |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching, Germany, Helmholtz Zentrum München, Neuherberg, Germany |
| authorships[14].author.id | https://openalex.org/A5006414766 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-1964-1900 |
| authorships[14].author.display_name | Ayyalusamy Ramamoorthy |
| authorships[14].countries | DE, US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[14].affiliations[0].raw_affiliation_string | Program in Biophysics, Department of Chemistry, University of Michigan, Ann Arbor, United States; |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I4210137766, https://openalex.org/I62916508 |
| authorships[14].affiliations[1].raw_affiliation_string | Institute for Advanced Study, Technische Universität München, Garching, Germany |
| authorships[14].institutions[0].id | https://openalex.org/I4210137766 |
| authorships[14].institutions[0].ror | https://ror.org/03xg85719 |
| authorships[14].institutions[0].type | facility |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210137766 |
| authorships[14].institutions[0].country_code | DE |
| authorships[14].institutions[0].display_name | Institute for Advanced Study |
| authorships[14].institutions[1].id | https://openalex.org/I62916508 |
| authorships[14].institutions[1].ror | https://ror.org/02kkvpp62 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I62916508 |
| authorships[14].institutions[1].country_code | DE |
| authorships[14].institutions[1].display_name | Technical University of Munich |
| authorships[14].institutions[2].id | https://openalex.org/I27837315 |
| authorships[14].institutions[2].ror | https://ror.org/00jmfr291 |
| authorships[14].institutions[2].type | education |
| authorships[14].institutions[2].lineage | https://openalex.org/I27837315 |
| authorships[14].institutions[2].country_code | US |
| authorships[14].institutions[2].display_name | University of Michigan |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Ayyalusamy Ramamoorthy |
| authorships[14].is_corresponding | True |
| authorships[14].raw_affiliation_strings | Institute for Advanced Study, Technische Universität München, Garching, Germany, Program in Biophysics, Department of Chemistry, University of Michigan, Ann Arbor, United States; |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.7554/elife.31226 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2017-12-04T00:00:00 |
| display_name | Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10086 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2737 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Alzheimer's disease research and treatments |
| related_works | https://openalex.org/W2461136032, https://openalex.org/W4296503608, https://openalex.org/W1721240973, https://openalex.org/W1989584462, https://openalex.org/W3045649528, https://openalex.org/W2031696333, https://openalex.org/W1782840739, https://openalex.org/W2015068531, https://openalex.org/W2244909814, https://openalex.org/W2079403467 |
| cited_by_count | 83 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 8 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 5 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 6 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 10 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 13 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 10 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 12 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 17 |
| counts_by_year[8].year | 2017 |
| counts_by_year[8].cited_by_count | 2 |
| locations_count | 6 |
| best_oa_location.id | doi:10.7554/elife.31226 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S1336409049 |
| best_oa_location.source.issn | 2050-084X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2050-084X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | eLife |
| best_oa_location.source.host_organization | https://openalex.org/P4310311710 |
| best_oa_location.source.host_organization_name | eLife Sciences Publications Ltd |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311710 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | eLife |
| best_oa_location.landing_page_url | https://doi.org/10.7554/elife.31226 |
| primary_location.id | doi:10.7554/elife.31226 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S1336409049 |
| primary_location.source.issn | 2050-084X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2050-084X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | eLife |
| primary_location.source.host_organization | https://openalex.org/P4310311710 |
| primary_location.source.host_organization_name | eLife Sciences Publications Ltd |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311710 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | eLife |
| primary_location.landing_page_url | https://doi.org/10.7554/elife.31226 |
| publication_date | 2017-11-17 |
| publication_year | 2017 |
| referenced_works | https://openalex.org/W1031578623, https://openalex.org/W2002837229, https://openalex.org/W2171115266, https://openalex.org/W2063431000, https://openalex.org/W2050494478, https://openalex.org/W1993552984, https://openalex.org/W2038438971, https://openalex.org/W2057477511, https://openalex.org/W2017114341, https://openalex.org/W2011139454, https://openalex.org/W2614053601, https://openalex.org/W2314292783, https://openalex.org/W2408969117, https://openalex.org/W2416828046, https://openalex.org/W1987066756, https://openalex.org/W2029476353, https://openalex.org/W2065232574, https://openalex.org/W2041143833, https://openalex.org/W2121937669, https://openalex.org/W2523046376, https://openalex.org/W2072675976, https://openalex.org/W2166025323, https://openalex.org/W1995272223, https://openalex.org/W2608970480, https://openalex.org/W2968895639, https://openalex.org/W2097786650, https://openalex.org/W2125989811, https://openalex.org/W2048266405, https://openalex.org/W2172762528, https://openalex.org/W2311550115, https://openalex.org/W1964727310, https://openalex.org/W2004154860, https://openalex.org/W2119267663, https://openalex.org/W2156771958, https://openalex.org/W2098651156, https://openalex.org/W2151888706, https://openalex.org/W2339559661, https://openalex.org/W2081693079, https://openalex.org/W2218446246, https://openalex.org/W2734328419, https://openalex.org/W2597394997, https://openalex.org/W2079659075, https://openalex.org/W1999143468, https://openalex.org/W2053202752, https://openalex.org/W2055155126, https://openalex.org/W2519805918, https://openalex.org/W2510806376, https://openalex.org/W2163128256, https://openalex.org/W2011148270, https://openalex.org/W2154996409, https://openalex.org/W2031742532, https://openalex.org/W2548449315, https://openalex.org/W1528511554, https://openalex.org/W2329582709, https://openalex.org/W2169707043, https://openalex.org/W2327174080, https://openalex.org/W2061111679, https://openalex.org/W2070114315, https://openalex.org/W1976154364, https://openalex.org/W2029625041, https://openalex.org/W2068834560, https://openalex.org/W2560541065, https://openalex.org/W1879024529, https://openalex.org/W2028390410 |
| referenced_works_count | 64 |
| abstract_inverted_index.a | 70, 88, 114 |
| abstract_inverted_index.MD | 84 |
| abstract_inverted_index.as | 131 |
| abstract_inverted_index.be | 121 |
| abstract_inverted_index.by | 55, 116 |
| abstract_inverted_index.in | 5, 35, 80, 87 |
| abstract_inverted_index.is | 3 |
| abstract_inverted_index.it | 45 |
| abstract_inverted_index.of | 10, 23, 38, 69, 125, 136, 147 |
| abstract_inverted_index.to | 40, 50, 65, 127, 141 |
| abstract_inverted_index.we | 60 |
| abstract_inverted_index.NMR | 62 |
| abstract_inverted_index.The | 123 |
| abstract_inverted_index.aid | 34 |
| abstract_inverted_index.and | 8, 17, 33, 83, 98, 107 |
| abstract_inverted_index.has | 46 |
| abstract_inverted_index.may | 120 |
| abstract_inverted_index.not | 47 |
| abstract_inverted_index.one | 135 |
| abstract_inverted_index.the | 11, 31, 36, 43, 52, 56, 67, 94, 101, 137, 143 |
| abstract_inverted_index.use | 61 |
| abstract_inverted_index.been | 48 |
| abstract_inverted_index.cell | 19, 57 |
| abstract_inverted_index.from | 93 |
| abstract_inverted_index.into | 30 |
| abstract_inverted_index.many | 9 |
| abstract_inverted_index.most | 138 |
| abstract_inverted_index.that | 100 |
| abstract_inverted_index.this | 110 |
| abstract_inverted_index.trap | 128 |
| abstract_inverted_index.Here, | 59 |
| abstract_inverted_index.While | 21 |
| abstract_inverted_index.could | 133 |
| abstract_inverted_index.human | 6, 74 |
| abstract_inverted_index.islet | 75 |
| abstract_inverted_index.posed | 54 |
| abstract_inverted_index.solve | 66 |
| abstract_inverted_index.treat | 42 |
| abstract_inverted_index.which | 117 |
| abstract_inverted_index.would | 26 |
| abstract_inverted_index.NFGAIL | 103 |
| abstract_inverted_index.become | 134 |
| abstract_inverted_index.death. | 20 |
| abstract_inverted_index.design | 37 |
| abstract_inverted_index.induce | 18 |
| abstract_inverted_index.region | 104 |
| abstract_inverted_index.type-2 | 71 |
| abstract_inverted_index.unique | 89 |
| abstract_inverted_index.within | 109 |
| abstract_inverted_index.ROSETTA | 82 |
| abstract_inverted_index.ability | 124 |
| abstract_inverted_index.amyloid | 1, 15, 76, 96, 129 |
| abstract_inverted_index.dissect | 142 |
| abstract_inverted_index.protein | 148 |
| abstract_inverted_index.provide | 27 |
| abstract_inverted_index.related | 73 |
| abstract_inverted_index.remains | 105 |
| abstract_inverted_index.species | 13 |
| abstract_inverted_index.diabetes | 72 |
| abstract_inverted_index.distinct | 92 |
| abstract_inverted_index.feasible | 49 |
| abstract_inverted_index.flexible | 106 |
| abstract_inverted_index.insights | 29 |
| abstract_inverted_index.isolated | 111 |
| abstract_inverted_index.overcome | 51 |
| abstract_inverted_index.pathways | 146 |
| abstract_inverted_index.powerful | 139 |
| abstract_inverted_index.resulted | 86 |
| abstract_inverted_index.revealed | 99 |
| abstract_inverted_index.compounds | 39 |
| abstract_inverted_index.diseases, | 7, 44 |
| abstract_inverted_index.formation | 2, 16 |
| abstract_inverted_index.mechanism | 115 |
| abstract_inverted_index.membrane. | 58 |
| abstract_inverted_index.nanodiscs | 126 |
| abstract_inverted_index.pathology | 32 |
| abstract_inverted_index.structure | 68, 91 |
| abstract_inverted_index.β-strand | 90 |
| abstract_inverted_index.accelerate | 14 |
| abstract_inverted_index.accessible | 108 |
| abstract_inverted_index.approaches | 140 |
| abstract_inverted_index.challenges | 53 |
| abstract_inverted_index.implicated | 4 |
| abstract_inverted_index.misfolding | 145 |
| abstract_inverted_index.nanodiscs. | 81 |
| abstract_inverted_index.nucleating | 102 |
| abstract_inverted_index.stabilized | 79 |
| abstract_inverted_index.structures | 22 |
| abstract_inverted_index.suggesting | 113 |
| abstract_inverted_index.tremendous | 28 |
| abstract_inverted_index.β-hairpin | 97 |
| abstract_inverted_index.aggregating | 12 |
| abstract_inverted_index.aggregation | 119 |
| abstract_inverted_index.complicated | 144 |
| abstract_inverted_index.constraints | 64 |
| abstract_inverted_index.polypeptide | 77 |
| abstract_inverted_index.potentially | 41 |
| abstract_inverted_index.propagated. | 122 |
| abstract_inverted_index.simulations | 85 |
| abstract_inverted_index.aggregation. | 149 |
| abstract_inverted_index.conventional | 95 |
| abstract_inverted_index.demonstrated | 132 |
| abstract_inverted_index.experimental | 63 |
| abstract_inverted_index.intermediate | 78 |
| abstract_inverted_index.intermediate, | 112 |
| abstract_inverted_index.intermediates | 25, 130 |
| abstract_inverted_index.Membrane-assisted | 0 |
| abstract_inverted_index.membrane-associated | 24, 118 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5006414766 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I27837315, https://openalex.org/I4210137766, https://openalex.org/I62916508 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.4399999976158142 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.97119044 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |