Staining and Quantitative Analysis of Myelinating Oligodendrocytes in the Mouse Grey Matter Article Swipe
Related Concepts
Myelin
Oligodendrocyte
Grey matter
White matter
Neuroscience
Biology
Staining
Myelin sheath
Cell biology
Central nervous system
Medicine
Genetics
Magnetic resonance imaging
Radiology
Matthew Swire
,
Charles ffrench‐Constant
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21769/bioprotoc.3792
· OA: W3094604858
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21769/bioprotoc.3792
· OA: W3094604858
Oligodendrocytes generate distinct patterns of myelination throughout the CNS. Variations in myelination along axons may enable neurons to fine-tune conduction velocities and alter signal synchronisation. Here we outline a staining protocol permitting the assessment of the number and length of myelin sheaths formed by oligodendrocyte in the mouse grey matter. This protocol enables the investigation of myelination without the need for reporter mice or technically challenging protocols, aiding the investigation of factors influencing myelin production in the brain.
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