Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection Article Swipe
Andreacarola Urso
,
Ian R. Monk
,
Ying-Tsun Chen
,
Camilla Predella
,
Tania Wong Fok Lung
,
Erin Theiller
,
J. M. Boylan
,
Sofya S. Perelman
,
Swikrity Upadhyay Baskota
,
Ahmed M. Moustafa
,
Gaurav Kumar Lohia
,
Ian A. Lewis
,
Benjamin P. Howden
,
Timothy P. Stinear
,
N. Valerio Dorrello
,
Victor J. Torres
,
Alice Prince
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41564-024-01769-9
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41564-024-01769-9
Staphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved in pathogenesis. Here we analysed transcriptomic responses of human clinical isolates of S. aureus from initial and chronic infections. We observed upregulated collagenase and proline transporter gene expression in chronic infection isolates. Metabolomics of bronchiolar lavage fluid and fibroblast infection, growth assays and analysis of bacterial mutant strains showed that airway fibroblasts produce collagen during S. aureus infection. Host-adapted bacteria upregulate collagenase, which degrades collagen and releases proline. S. aureus then imports proline, which fuels oxidative metabolism via the tricarboxylic acid cycle. Proline metabolism provides host-adapted S. aureus with a metabolic benefit enabling out-competition of non-adapted strains. These data suggest that clinical settings characterized by airway repair processes and fibrosis provide a milieu that promotes S. aureus adaptation and supports infection.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41564-024-01769-9
- OA Status
- hybrid
- Cited By
- 13
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401521586
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401521586Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41564-024-01769-9Digital Object Identifier
- Title
-
Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infectionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-12Full publication date if available
- Authors
-
Andreacarola Urso, Ian R. Monk, Ying-Tsun Chen, Camilla Predella, Tania Wong Fok Lung, Erin Theiller, J. M. Boylan, Sofya S. Perelman, Swikrity Upadhyay Baskota, Ahmed M. Moustafa, Gaurav Kumar Lohia, Ian A. Lewis, Benjamin P. Howden, Timothy P. Stinear, N. Valerio Dorrello, Victor J. Torres, Alice PrinceList of authors in order
- Landing page
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https://doi.org/10.1038/s41564-024-01769-9Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1038/s41564-024-01769-9Direct OA link when available
- Concepts
-
Staphylococcus aureus, Microbiology, Chronic infection, Biology, Virulence, Pathogenesis, Proline, Downregulation and upregulation, Staphylococcal infections, Immunology, Bacteria, Amino acid, Gene, Biochemistry, Immune system, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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